دورية أكاديمية
أعرض في EDS

Dissection of Cancer Mutational Signatures with Individual Components of Cigarette Smoking.

التفاصيل البيبلوغرافية
العنوان: Dissection of Cancer Mutational Signatures with Individual Components of Cigarette Smoking.
المؤلفون: Mingard C; Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 9, Zürich, CH 8092, Switzerland., Battey JND; PMI R&D, Philip Morris Products SA, Quai Jeanrenaud 5, Neuchâtel, CH 2000, Switzerland., Takhaveev V; Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 9, Zürich, CH 8092, Switzerland., Blatter K; Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 9, Zürich, CH 8092, Switzerland., Hürlimann V; Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 9, Zürich, CH 8092, Switzerland., Sierro N; PMI R&D, Philip Morris Products SA, Quai Jeanrenaud 5, Neuchâtel, CH 2000, Switzerland., Ivanov NV; PMI R&D, Philip Morris Products SA, Quai Jeanrenaud 5, Neuchâtel, CH 2000, Switzerland., Sturla SJ; Department of Health Sciences and Technology, ETH Zurich, Schmelzbergstrasse 9, Zürich, CH 8092, Switzerland.
المصدر: Chemical research in toxicology [Chem Res Toxicol] 2023 Apr 17; Vol. 36 (4), pp. 714-723. Date of Electronic Publication: 2023 Mar 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5010 (Electronic) Linking ISSN: 0893228X NLM ISO Abbreviation: Chem Res Toxicol Subsets: MEDLINE
أسماء مطبوعة: Publication: Washington Dc : American Chemical Society
Original Publication: Washington, DC : American Chemical Society, c1988-
مواضيع طبية MeSH: Cigarette Smoking* , Tobacco Smoke Pollution* , Lung Neoplasms*/genetics, Humans ; Benzo(a)pyrene ; Mutation ; DNA
مستخلص: Tobacco smoke delivers a complex mixture of hazardous and potentially hazardous chemicals. Some of these may induce the formation of DNA mutations, which increases the risk of various cancers that display characteristic patterns of accumulated mutations arising from the causative exposures. Tracking the contributions of individual mutagens to mutational signatures present in human cancers can help understand cancer etiology and advance disease prevention strategies. To characterize the potential contributions of individual constituents of tobacco smoke to tobacco exposure-associated mutational signatures, we first assessed the toxic potential of 13 tobacco-relevant compounds by determining their impact on the viability of a human bronchial lung epithelial cell line (BEAS-2B). Experimentally derived high-resolution mutational profiles were characterized for the seven most potent compounds by sequencing the genomes of clonally expanded mutants that arose after exposure to the individual chemicals. Analogous to the classification of mutagenic processes on the basis of signatures from human cancers, we extracted mutational signatures from the mutant clones. We confirmed the formation of previously characterized benzo[ a ]pyrene mutational signatures. Furthermore, we discovered three novel mutational signatures. The mutational signatures arising from benzo[ a ]pyrene and norharmane were similar to human lung cancer signatures attributed to tobacco smoking. However, the signatures arising from N -methyl- N '-nitro- N -nitrosoguanidine and 4-(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone were not directly related to known tobacco-linked mutational signatures from human cancers. This new data set expands the scope of the in vitro mutational signature catalog and advances understanding of how environmental agents mutate DNA.
References: Chem Soc Rev. 2020 Oct 21;49(20):7354-7377. (PMID: 32968744)
Acta Biochim Biophys Sin (Shanghai). 2015 Jul;47(7):477-87. (PMID: 26040315)
Curr Pharmacol Rep. 2016 Apr;2(2):64-72. (PMID: 27034917)
Int J Cancer. 2014 May 15;134(10):2278-83. (PMID: 24243522)
Science. 2016 Nov 4;354(6312):618-622. (PMID: 27811275)
Cancer Lett. 1999 Sep 1;143(2):139-43. (PMID: 10503893)
Mutat Res. 1990 Jul;231(1):11-30. (PMID: 2195323)
Carcinogenesis. 2003 Dec;24(12):1985-93. (PMID: 12970073)
Mutat Res. 2002 Sep 30;506-507:49-54. (PMID: 12351144)
Chem Res Toxicol. 2020 Feb 17;33(2):625-633. (PMID: 31841318)
J Am Chem Soc. 2018 Aug 8;140(31):9783-9787. (PMID: 29944356)
Mutat Res. 1983 May;113(3-4):173-215. (PMID: 6341825)
Carcinogenesis. 1996 Jul;17(7):1499-503. (PMID: 8706255)
PLoS One. 2019 Sep 12;14(9):e0221235. (PMID: 31513583)
Genome Res. 2017 Sep;27(9):1475-1486. (PMID: 28739859)
Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6443-7. (PMID: 8692834)
Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3101-E3109. (PMID: 28351974)
ACS Cent Sci. 2023 Feb 22;9(3):362-372. (PMID: 36968528)
Cell. 2012 May 25;149(5):979-93. (PMID: 22608084)
Science. 2020 Oct 2;370(6512):75-82. (PMID: 33004514)
Toxicol Appl Pharmacol. 2015 Sep 15;287(3):240-5. (PMID: 26091798)
Chem Res Toxicol. 2002 Feb;15(2):165-9. (PMID: 11849042)
Cancer Res. 2009 Apr 1;69(7):2990-5. (PMID: 19318550)
Mutat Res. 1993 Nov;303(3):127-33. (PMID: 7694129)
Chem Res Toxicol. 2005 Jun;18(6):1048-55. (PMID: 15962940)
Carcinogenesis. 1993 Sep;14(9):1915-9. (PMID: 8403218)
Chem Res Toxicol. 1997 May;10(5):562-7. (PMID: 9168254)
Chem Res Toxicol. 2004 May;17(5):588-97. (PMID: 15144215)
Toxicol In Vitro. 2013 Sep;27(6):1719-27. (PMID: 23669205)
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Mar 25;802(1):135-41. (PMID: 15036005)
Nat Rev Cancer. 2021 Oct;21(10):619-637. (PMID: 34316057)
Nature. 2020 Feb;578(7793):94-101. (PMID: 32025018)
DNA Repair (Amst). 2015 Nov;35:63-70. (PMID: 26460881)
Cell Genom. 2022 Nov 09;2(11):None. (PMID: 36388765)
Nat Rev Cancer. 2012 Jan 12;12(2):104-20. (PMID: 22237395)
PLoS One. 2013 Nov 08;8(11):e78356. (PMID: 24260113)
Chem Res Toxicol. 2017 Jan 17;30(1):420-433. (PMID: 28092943)
Cell. 2019 May 2;177(4):821-836.e16. (PMID: 30982602)
Genome Med. 2018 Apr 25;10(1):33. (PMID: 29695279)
J Biol Chem. 2002 Apr 5;277(14):11765-71. (PMID: 11821420)
Carcinogenesis. 1998 Nov;19(11):1995-2000. (PMID: 9855015)
Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. (PMID: 25435355)
Mol Biol Evol. 1987 May;4(3):203-21. (PMID: 3328815)
Oncogene. 2017 Oct 26;36(43):6041-6048. (PMID: 28692054)
Sci Rep. 2014 Mar 27;4:4482. (PMID: 24670820)
Nature. 2013 Aug 22;500(7463):415-21. (PMID: 23945592)
DNA Repair (Amst). 2002 Feb 28;1(2):125-35. (PMID: 12509259)
Nat Commun. 2018 May 1;9(1):1744. (PMID: 29717121)
المشرفين على المادة: 3417WMA06D (Benzo(a)pyrene)
0 (Tobacco Smoke Pollution)
9007-49-2 (DNA)
تواريخ الأحداث: Date Created: 20230328 Date Completed: 20230418 Latest Revision: 20240328
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC10114081
DOI: 10.1021/acs.chemrestox.3c00021
PMID: 36976926
قاعدة البيانات: MEDLINE
الوصف
تدمد:1520-5010
DOI:10.1021/acs.chemrestox.3c00021