دورية أكاديمية
أعرض في EDS

Methacrylate Cationic Nanoparticles Activity against Different Gram-Positive Bacteria.

التفاصيل البيبلوغرافية
العنوان: Methacrylate Cationic Nanoparticles Activity against Different Gram-Positive Bacteria.
المؤلفون: Nam-Cha SH; Department of Pathology, Complejo Hospitalario Universitario, 02006 Albacete, Spain., Ocaña AV; Instituto de Investigación en Discapacidades Neurológicas (IDINE), University of Castilla-La Mancha, 02001 Albacete, Spain., Pérez-Tanoira R; Clinical Microbiology Department, Hospital Universitario Príncipe de Asturias, 28805 Madrid, Spain.; Biomedicine y Biotechnology Department, School of Medicine, University of Alcalá de Henares, 28054 Madrid, Spain., Aguilera-Correa JJ; Clinical Microbiology Department, IIS-Fundacion Jimenez Diaz-UAM, 28040 Madrid, Spain., Domb AJ; Institute of Drug Research, School of Pharmacy-Faculty of Medicine, Center for Nanoscience and Nanotechnology and The Alex Grass Center for Drug Design and Synthesis, The Hebrew University of Jerusalem, Jerusalem 91120, Israel., Ruiz-Grao MC; Department of Nursing, University of Castilla-La Mancha, 02071 Albacete, Spain.; Health and Social Research Center, University of Castilla-La Mancha, 16071 Cuenca, Spain., Cebada-Sánchez S; Department of Nursing, University of Castilla-La Mancha, 02071 Albacete, Spain., López-Gónzalez Á; Department of Nursing, University of Castilla-La Mancha, 02071 Albacete, Spain., Molina-Alarcón M; Instituto de Investigación en Discapacidades Neurológicas (IDINE), University of Castilla-La Mancha, 02001 Albacete, Spain.; Department of Nursing, University of Castilla-La Mancha, 02071 Albacete, Spain., Pérez-Martínez J; BIOTYC Foundation, C/Blasco de Garay 27, 02003 Albacete, Spain.; Department of Nephrology, Complejo Hospitalario Universitario, 02006 Albacete, Spain., Pérez-Martínez FC; Instituto de Investigación en Discapacidades Neurológicas (IDINE), University of Castilla-La Mancha, 02001 Albacete, Spain.; Department of Nursing, University of Castilla-La Mancha, 02071 Albacete, Spain.; BIOTYC Foundation, C/Blasco de Garay 27, 02003 Albacete, Spain.
المصدر: Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2023 Mar 07; Vol. 12 (3). Date of Electronic Publication: 2023 Mar 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101637404 Publication Model: Electronic Cited Medium: Print ISSN: 2079-6382 (Print) Linking ISSN: 20796382 NLM ISO Abbreviation: Antibiotics (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2012-
مستخلص: Nanotechnology is a developing field that has boomed in recent years due to the multiple qualities of nanoparticles (NPs), one of which is their antimicrobial capacity. We propose that NPs anchored with 2-(dimethylamino)ethyl methacrylate (DMAEMA) have antibacterial properties and could constitute an alternative tool in this field. To this end, the antimicrobial effects of three quaternised NPs anchored with DMAEMA were studied. These NPs were later copolymerized using different methylmethacrylate (MMA) concentrations to evaluate their role in the antibacterial activity shown by NPs. Clinical strains of Staphylococcus aureus , S. epidermidis , S. lugdunensis and Enterococcus faecalis were used to assess antibacterial activity. The minimal inhibitory concentration (MIC) was determined at the different concentrations of NPs to appraise antibacterial activity. The cytotoxic effects of the NPs anchored with DMAEMA were determined in NIH 3 T 3 mouse fibroblast cultures by MTT assays. All the employed NPs were effective against the studied bacterial strains, although increasing concentrations of the MMA added during the synthesis process diminished these effects without altering toxicity in cell cultures. To conclude, more studies with other copolymers are necessary to improve the antibacterial effects of NPs anchored with DMAEMA.
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فهرسة مساهمة: Keywords: DMAEMA; MMA; antibacterial activity; nanoparticles
تواريخ الأحداث: Date Created: 20230329 Latest Revision: 20230331
رمز التحديث: 20230331
مُعرف محوري في PubMed: PMC10044577
DOI: 10.3390/antibiotics12030533
PMID: 36978400
قاعدة البيانات: MEDLINE
الوصف
تدمد:2079-6382
DOI:10.3390/antibiotics12030533