دورية أكاديمية
أعرض في EDS

Sexual Dimorphism in the Expression of Cardiac and Hippocampal Renin-Angiotensin and Kallikrein-Kinin Systems in Offspring from Mice Exposed to Alcohol during Gestation.

التفاصيل البيبلوغرافية
العنوان: Sexual Dimorphism in the Expression of Cardiac and Hippocampal Renin-Angiotensin and Kallikrein-Kinin Systems in Offspring from Mice Exposed to Alcohol during Gestation.
المؤلفون: da Silva GA; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil., Atum ALB; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil., de Matos LP; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil., Nasuk GR; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil., de Jesus BC; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil., Gouveia TLF; Odontology Department, Ágora Faculty, Av. Sorrento, Campo Novo do Parecis 78360-000, MT, Brazil.; Biomedicine Department, Finaci Faculty, Rua São Joaquim, 352 Liberdade, São Paulo 01508-901, SP, Brazil., Baltatu OC; Center of Innovation, Technology and Education (CITE), Anhembi Morumbi University, Anima Institute, Sao Jose dos Campos Technology Park, Sao Jose dos Campos 12247-016, SP, Brazil., Zamuner SR; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil., Silva Júnior JA; Medicine Department, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 249, Liberdade, São Paulo 01504-001, SP, Brazil.
المصدر: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Feb 21; Vol. 12 (3). Date of Electronic Publication: 2023 Feb 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101668981 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3921 (Print) Linking ISSN: 20763921 NLM ISO Abbreviation: Antioxidants (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: Prenatal alcohol exposure (PAE) impairs fetal development. Alcohol consumption was shown to modulate the renin-angiotensin system (RAS). This study aimed to analyze the effects of PAE on the expression of the renin-angiotensin system (RAS) and kallikrein-kinin system (KKS) peptide systems in the hippocampus and heart of mice of both sexes. C57Bl/6 mice were exposed to alcohol during pregnancy at a concentration of 10% ( v / v ). On postnatal day 45 (PN45), mouse hippocampi and left ventricles (LV) were collected and processed for messenger RNA (mRNA) expression of components of the RAS and KKS. In PAE animals, more pronounced expression of AT1 and ACE mRNAs in males and a restored AT2 mRNA expression in females were observed in both tissues. In LV, increased AT2 , ACE2 , and B2 mRNA expressions were also observed in PAE females. Furthermore, high levels of H 2 O 2 were observed in males from the PAE group in both tissues. Taken together, our results suggest that modulation of the expression of these peptidergic systems in PAE females may make them less susceptible to the effects of alcohol.
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معلومات مُعتمدة: 312381/2021-2 National Council for Scientific and Technological Development
فهرسة مساهمة: Keywords: heart; hippocampus; kallikrein–kinin system; oxidative stress; prenatal alcohol exposure; renin–angiotensin system
تواريخ الأحداث: Date Created: 20230329 Latest Revision: 20230331
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10045732
DOI: 10.3390/antiox12030541
PMID: 36978790
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-3921
DOI:10.3390/antiox12030541