دورية أكاديمية

Qualitative Evaluation of Intracranial Pressure Slopes in Patients Undergoing Brain Death Protocol.

التفاصيل البيبلوغرافية
العنوان: Qualitative Evaluation of Intracranial Pressure Slopes in Patients Undergoing Brain Death Protocol.
المؤلفون: Ideta MML; Department of Internal Medicine, Federal University of Amazonas, Manaus 69077, ZIP, Brazil., Oliveira LM; Department of Neurology, University of São Paulo, Ribeirão Preto 14049, ZIP, Brazil., Gonçalves DB; Department of Internal Medicine, Federal University of Amazonas, Manaus 69077, ZIP, Brazil., Paschoalino MC; Department of Internal Medicine, Federal University of Amazonas, Manaus 69077, ZIP, Brazil., Carvalho NA; Department of Internal Medicine, Federal University of Amazonas, Manaus 69077, ZIP, Brazil., Della Coletta MV; Department of Neurology, Amazonas State University, Manaus 69005, ZIP, Brazil., Paiva W; Division of Neurosurgery, Department of Neurology, University of São Paulo, São Paulo 01246, ZIP, Brazil., Brasil S; Division of Neurosurgery, Department of Neurology, University of São Paulo, São Paulo 01246, ZIP, Brazil., Amorim RLO; Department of Internal Medicine, Federal University of Amazonas, Manaus 69077, ZIP, Brazil.; Division of Neurosurgery, Department of Neurology, University of São Paulo, São Paulo 01246, ZIP, Brazil.
المصدر: Brain sciences [Brain Sci] 2023 Feb 25; Vol. 13 (3). Date of Electronic Publication: 2023 Feb 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101598646 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3425 (Print) Linking ISSN: 20763425 NLM ISO Abbreviation: Brain Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: Background: Due to the importance of not mistaking when determining the brain death (BD) diagnostic, reliable confirmatory exams should be performed to enhance its security. This study aims to evaluate the intracranial pressure (ICP) pulse morphology behavior in brain-dead patients through a noninvasive monitoring system.
Methods: A pilot case-control study was conducted in adults that met the BD national protocol criteria. Quantitative parameters from the ICP waveforms, such as the P2/P1 ratio, time-to-peak (TTP) and pulse amplitude (AMP) were extracted and analyzed comparing BD patients and health subjects.
Results: Fifteen patients were included, and 6172 waveforms were analyzed. ICP waveforms presented substantial differences amidst BD patients when compared to the control group, especially AMP, which had lower values in patients diagnosed with BD ( p < 0.0001) and the TTP median ( p < 0.00001), but no significance was found for the P2/P1 ratio ( p = 0.8). The area under curve for combination of parameters on the BD prediction was 0.77.
Conclusions: In this exploratory study, noninvasive ICP waveforms have shown potential as a screening method in patients with suspected brain death. Future studies should be carried out in a larger population.
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فهرسة مساهمة: Keywords: brain death diagnosis; intracranial compliance; intracranial pressure
تواريخ الأحداث: Date Created: 20230329 Latest Revision: 20230331
رمز التحديث: 20230331
مُعرف محوري في PubMed: PMC10046080
DOI: 10.3390/brainsci13030401
PMID: 36979211
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-3425
DOI:10.3390/brainsci13030401