دورية أكاديمية
أعرض في EDS

Differential Spatial Gene and Protein Expression Associated with Recurrence Following Chemoradiation for Localized Anal Squamous Cell Cancer.

التفاصيل البيبلوغرافية
العنوان: Differential Spatial Gene and Protein Expression Associated with Recurrence Following Chemoradiation for Localized Anal Squamous Cell Cancer.
المؤلفون: Hernandez S; Translational Molecular Pathology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Das P; Gastrointestinal Radiation Oncology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Holliday EB; Gastrointestinal Radiation Oncology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Shen L; Bioinformatics, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Lu W; Translational Molecular Pathology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Johnson B; Gastrointestinal Medical Oncology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Messick CA; Colon and Rectal Surgery, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Taniguchi CM; Gastrointestinal Radiation Oncology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Skibber J; Colon and Rectal Surgery, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Ludmir EB; Gastrointestinal Radiation Oncology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., You YN; Colon and Rectal Surgery, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Smith GL; Gastrointestinal Radiation Oncology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Bednarski B; Colon and Rectal Surgery, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Kostousov L; Translational Molecular Pathology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Koay EJ; Gastrointestinal Radiation Oncology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Minsky BD; Gastrointestinal Radiation Oncology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Tillman M; Colon and Rectal Surgery, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Portier S; Gastrointestinal Medical Oncology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Eng C; Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA., Koong AC; Gastrointestinal Radiation Oncology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Chang GJ; Colon and Rectal Surgery, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Foo WC; Pathology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Wang J; Bioinformatics, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Soto LS; Translational Molecular Pathology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA., Morris VK; Gastrointestinal Medical Oncology, The University of Texas-MD Anderson Cancer Center, Houston, TX 77030, USA.
المصدر: Cancers [Cancers (Basel)] 2023 Mar 10; Vol. 15 (6). Date of Electronic Publication: 2023 Mar 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: The identification of transcriptomic and protein biomarkers prognosticating recurrence risk after chemoradiation of localized squamous cell carcinoma of the anus (SCCA) has been limited by a lack of available fresh tissue at initial presentation. We analyzed archival FFPE SCCA specimens from pretreatment biopsies prior to chemoradiation for protein and RNA biomarkers from patients with localized SCCA who recurred (N = 23) and who did not recur (N = 25). Tumor cells and the tumor microenvironment (TME) were analyzed separately to identify biomarkers with significantly different expression between the recurrent and non-recurrent groups. Recurrent patients had higher mean protein expression of FoxP3, MAPK-activation markers (BRAF, p38-MAPK) and PI3K/Akt activation (phospho-Akt) within the tumor regions. The TME was characterized by the higher protein expression of immune checkpoint biomarkers such as PD-1, OX40L and LAG3. For patients with recurrent SCCA, the higher mean protein expression of fibronectin was observed in the tumor and TME compartments. No significant differences in RNA expression were observed. The higher baseline expression of immune checkpoint biomarkers, together with markers of MAPK and PI3K/Akt signaling, are associated with recurrence following chemoradiation for patients with localized SCCA. These data provide a rationale towards the application of immune-based therapeutic strategies to improve curative-intent outcomes beyond conventional therapies for patients with SCCA.
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معلومات مُعتمدة: K12 CA088084 United States CA NCI NIH HHS; K12 CA088084 United States NH NIH HHS
فهرسة مساهمة: Keywords: chemoradiation; digital spatial profiling; protein profiling; recurrence; squamous anal cell carcinoma
تواريخ الأحداث: Date Created: 20230329 Latest Revision: 20231102
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10046657
DOI: 10.3390/cancers15061701
PMID: 36980587
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6694
DOI:10.3390/cancers15061701