دورية أكاديمية
أعرض في EDS

Multimodal Prehabilitation in Patients Undergoing Complex Colorectal Surgery, Liver Resection, and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Pilot Study on Feasibility and Potential Efficacy.

التفاصيل البيبلوغرافية
العنوان: Multimodal Prehabilitation in Patients Undergoing Complex Colorectal Surgery, Liver Resection, and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Pilot Study on Feasibility and Potential Efficacy.
المؤلفون: Strijker D; Department of Surgery, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands., Meijerink WJHJ; Department of Operating Rooms, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands., van Heusden-Schotalbers LAG; Department of Rehabilitation, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands., van den Berg MGA; Department of Gastroenterology and Hepatology-Dietetics and Intestinal Failure, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands., van Asseldonk MJMD; Department of Gastroenterology and Hepatology-Dietetics and Intestinal Failure, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands., Drager LD; Department of Operating Rooms, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands., de Wilt JHW; Department of Surgery, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands., van Laarhoven KJHM; Department of Surgery, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands., van den Heuvel B; Department of Operating Rooms, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.
المصدر: Cancers [Cancers (Basel)] 2023 Mar 20; Vol. 15 (6). Date of Electronic Publication: 2023 Mar 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: Background: Surgery for complex primary and metastatic colorectal cancer (CRC), such as liver resection and hyperthermic intraperitoneal chemotherapy (HIPEC), in academic settings has led to improved survival but is associated with complications up to 75%. Prehabilitation has been shown to prevent complications in non-academic hospitals. This pilot study aimed to determine the feasibility and potential efficacy of a multimodal prehabilitation program in patients undergoing surgery in an academic hospital for complex primary and metastatic CRC.
Methods: All patients awaiting complex colorectal surgery, liver resection, or HIPEC from July 2019 until January 2020 were considered potentially eligible. Feasibility was measured by accrual rate, completion rate, adherence to the program, satisfaction, and safety. To determine potential efficacy, postoperative outcomes were compared with a historical control group.
Results: Sixteen out of twenty-five eligible patients (64%) commenced prehabilitation, and fourteen patients fully completed the intervention (88%). The adherence rate was 69%, as 11 patients completed >80% of prescribed supervised trainings. No adverse events occurred, and all patients expressed satisfaction with the program. The complication rate was significantly lower in the prehabilitation group (37.5%) than the control group (70.2%, p = 0.020). There was no difference in the type of complications.
Conclusion: This pilot study illustrates that multimodal prehabilitation is feasible in the majority of patients undergoing complex colorectal cancer, liver resection, and HIPEC in an academic setting.
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فهرسة مساهمة: Keywords: colorectal neoplasm MeSH; colorectal surgery MeSH; hyperthermic intraperitoneal chemotherapy; neoplasm metastasis MeSH; perioperative care; postoperative complications MeSH; prehabilitation
تواريخ الأحداث: Date Created: 20230329 Latest Revision: 20230331
رمز التحديث: 20230331
مُعرف محوري في PubMed: PMC10047129
DOI: 10.3390/cancers15061870
PMID: 36980756
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6694
DOI:10.3390/cancers15061870