دورية أكاديمية
Pro-Arrhythmic Potential of Accumulated Uremic Toxins Is Mediated via Vulnerability of Action Potential Repolarization.
| العنوان: | Pro-Arrhythmic Potential of Accumulated Uremic Toxins Is Mediated via Vulnerability of Action Potential Repolarization. |
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| المؤلفون: | van Ham WB; Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Cornelissen CM; Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Polyakova E; Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van der Voorn SM; Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Ligtermoet ML; Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Monshouwer-Kloots J; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Vos MA; Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Bossu A; Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van Rooij E; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van der Heyden MAG; Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., van Veen TAB; Department of Medical Physiology, Division Heart & Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. |
| المصدر: | International journal of molecular sciences [Int J Mol Sci] 2023 Mar 11; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
| مواضيع طبية MeSH: | Induced Pluripotent Stem Cells*/metabolism , Renal Insufficiency, Chronic*/metabolism, Humans ; Uremic Toxins ; HEK293 Cells ; Action Potentials ; Renal Dialysis ; Myocytes, Cardiac |
| مستخلص: | Chronic kidney disease (CKD) is represented by a diminished filtration capacity of the kidneys. End-stage renal disease patients need dialysis treatment to remove waste and toxins from the circulation. However, endogenously produced uremic toxins (UTs) cannot always be filtered during dialysis. UTs are among the CKD-related factors that have been linked to maladaptive and pathophysiological remodeling of the heart. Importantly, 50% of the deaths in dialysis patients are cardiovascular related, with sudden cardiac death predominating. However, the mechanisms responsible remain poorly understood. The current study aimed to assess the vulnerability of action potential repolarization caused by exposure to pre-identified UTs at clinically relevant concentrations. We exposed human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and HEK293 chronically (48 h) to the UTs indoxyl sulfate, kynurenine, or kynurenic acid. We used optical and manual electrophysiological techniques to assess action potential duration (APD) in the hiPSC-CMs and recorded I |
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| معلومات مُعتمدة: | YTP2018 CVON RECONNECT; DCVA2018-30 PREDICT2 Dutch CardioVascular Alliance with support of the Dutch Heart Foundation |
| فهرسة مساهمة: | Keywords: KV11.1; cardiac repolarization; cellular electrophysiology; chronic kidney disease; uremic toxins |
| المشرفين على المادة: | 0 (Uremic Toxins) |
| تواريخ الأحداث: | Date Created: 20230329 Date Completed: 20230330 Latest Revision: 20230331 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10049510 |
| DOI: | 10.3390/ijms24065373 |
| PMID: | 36982449 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1422-0067 |
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| DOI: | 10.3390/ijms24065373 |