دورية أكاديمية
Chemical Composition, Antibacterial Activity and In Vitro Anticancer Evaluation of Ochradenus baccatus Methanolic Extract.
العنوان: | Chemical Composition, Antibacterial Activity and In Vitro Anticancer Evaluation of Ochradenus baccatus Methanolic Extract. |
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المؤلفون: | Khojali WMA; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia.; Department of Pharmaceutical Chemistry, College of Pharmacy, Omdurman Islamic University, Al Khartoum 14415, Sudan., Hussein W; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Aden University, Aden 6075, Yemen., Bin Break MK; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia., Alafnan A; Department of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia., Huwaimel B; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia., Khalifa NE; Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia.; Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum 11115, Sudan., Badulla WFS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Aden University, Aden 6075, Yemen., Alshammari RA; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia., Alshammari LK; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia., Alshammari RAR; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia., Albarak SM; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia., Alrkad EH; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia., Mahboob T; Faculty of Pharmaceutical Sciences, UCSI University, KL Campus, Kuala Lumpur 56000, Malaysia., Alshammari H; Department of Clinical Pharmacy, College of Pharmacy, University of Hail, Hail 2240, Saudi Arabia. |
المصدر: | Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2023 Mar 10; Vol. 59 (3). Date of Electronic Publication: 2023 Mar 10. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2018- : Basel, Switzerland : MDPI Original Publication: Kaunas : Lietuvos gydytojų sąjunga |
مواضيع طبية MeSH: | Methanol* , Resedaceae*, Animals ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Medicine, Traditional |
مستخلص: | Background and Objectives: Ochradenus baccatus belongs to the family Resedaceae. It is widely spread in Saudi Arabia and other countries in Southwest Asia. O. baccatus is extensively used in traditional medicine as an anti-inflammatory and antibacterial agent, in addition to being a vital source of food for certain desert animal species. The aim of the present study was to investigate the chemical composition and antibacterial/anticancer activities of O. baccatus methanolic extracts collected from Hail, Saudi Arabia. Materials and Methods: The O. baccatus extracts were obtained by macerating the crude powder in methanol, followed by filtration and evaporation. Liquid chromatography-mass spectrometry ( LC-MS ) was used to analyze the methanolic extracts' chemical constituents. Broth microdilution assay for minimum inhibitory concentration (MIC) determination was used to assess antimicrobial activity, while the extracts' anticancer potential was assessed by sulforhodamine B Assay (SRB) assay. Results: The results of the antibacterial assay showed that the methanolic extracts from the roots and branches possessed varying degrees of activity against particular bacterial strains, with the highest activity being exerted by the branches' extract against Escherichia coli and Salmonella typhimurium (St), demonstrating MIC values of 15.6 µg/mL and 20 µg/mL, respectively. Furthermore, the SRB cell viability assay revealed that only the branches' extract inhibited the growth of A549 cancer cells, with an IC |
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معلومات مُعتمدة: | RG-21 173. University of Hail |
فهرسة مساهمة: | Keywords: Hail; Ochradenus baccatus; antibacterial; cytotoxicity; phytochemicals |
المشرفين على المادة: | Y4S76JWI15 (Methanol) 0 (Plant Extracts) 0 (Anti-Bacterial Agents) |
تواريخ الأحداث: | Date Created: 20230329 Date Completed: 20230330 Latest Revision: 20230331 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10054464 |
DOI: | 10.3390/medicina59030546 |
PMID: | 36984547 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1648-9144 |
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DOI: | 10.3390/medicina59030546 |