دورية أكاديمية
أعرض في EDS

Current perspectives on resistance to chimeric antigen receptor T-cell therapy and strategies to improve efficacy in B-cell lymphoma.

التفاصيل البيبلوغرافية
العنوان: Current perspectives on resistance to chimeric antigen receptor T-cell therapy and strategies to improve efficacy in B-cell lymphoma.
المؤلفون: Ong SY; Department of Haematology, Singapore General Hospital, Singapore, Singapore., Chen Y; Department of Haematology, Singapore General Hospital, Singapore, Singapore., Tan MSY; Department of Haematology, Singapore General Hospital, Singapore, Singapore., Ho AYL; Department of Haematology, Singapore General Hospital, Singapore, Singapore., Hwang WYK; Department of Haematology, Singapore General Hospital, Singapore, Singapore.; Division of Medical Oncology, National Cancer Centre, Singapore, Singapore., Lim FLWI; Department of Haematology, Singapore General Hospital, Singapore, Singapore.
المصدر: European journal of haematology [Eur J Haematol] 2024 Feb; Vol. 112 (2), pp. 144-152. Date of Electronic Publication: 2023 Apr 03.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Blackwell Country of Publication: England NLM ID: 8703985 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0609 (Electronic) Linking ISSN: 09024441 NLM ISO Abbreviation: Eur J Haematol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005->: Oxford : Blackwell
Original Publication: Copenhagen : Munksgaard, c1987-
مواضيع طبية MeSH: Receptors, Chimeric Antigen*/genetics , Lymphoma, B-Cell*/therapy, Humans ; Immunotherapy, Adoptive/adverse effects ; Receptors, Antigen, T-Cell/genetics ; Antigens, CD19 ; Recurrence ; Cell- and Tissue-Based Therapy ; Tumor Microenvironment
مستخلص: Although chimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable efficacy in patients with chemo-refractory B-cell lymphoma, a significant portion is refractory or relapse. Resistance is a major barrier to improving treatment efficacy and long-term survival in CAR T-cell therapy, and clinicians have very limited tools to discriminate a priori patients who will or will not respond to treatment. While CD19-negative relapses due to loss of target antigen is well described, it accounts for only about 30% of cases with treatment failure. Recent efforts have shed light on mechanisms of CD19-positive relapse due to tumor intrinsic resistance, T-cell quality/manufacturing, or CAR T-cell exhaustion mediated by hostile tumor microenvironment. Here, we review the latest updates of preclinical and clinical trials to investigate the mechanisms of resistance and relapse post CAR T-cell therapy in B cell lymphoma and discuss novel treatment strategies to overcome resistance as well as advances that are useful for a CAR T therapist to optimize and personalize CAR T-cell therapy.
(© 2023 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: B-cell lymphoma; CD19; T cell exhaustion; antigen escape; chimeric antigen receptor
المشرفين على المادة: 0 (Receptors, Chimeric Antigen)
0 (Receptors, Antigen, T-Cell)
0 (Antigens, CD19)
تواريخ الأحداث: Date Created: 20230329 Date Completed: 20240117 Latest Revision: 20240117
رمز التحديث: 20240117
DOI: 10.1111/ejh.13964
PMID: 36987995
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-0609
DOI:10.1111/ejh.13964