دورية أكاديمية
أعرض في EDS

Markers of arterial stiffness and urinary metabolomics in young adults with early cardiovascular risk: the African-PREDICT study.

التفاصيل البيبلوغرافية
العنوان: Markers of arterial stiffness and urinary metabolomics in young adults with early cardiovascular risk: the African-PREDICT study.
المؤلفون: du Toit WL; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa., Kruger R; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Gafane-Matemane LF; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Schutte AE; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.; School of Population Health, University of New South Wales, Sydney, Australia.; The George Institute for Global Health, Sydney, Australia., Louw R; Human Metabolomics, North-West University, Potchefstroom Campus, Potchefstroom, South Africa., Mels CMC; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa. carina.mels@nwu.ac.za.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. carina.mels@nwu.ac.za.
المصدر: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2023 Mar 29; Vol. 19 (4), pp. 28. Date of Electronic Publication: 2023 Mar 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101274889 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-3890 (Electronic) Linking ISSN: 15733882 NLM ISO Abbreviation: Metabolomics Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Springer, c2006-
مواضيع طبية MeSH: Cardiovascular Diseases* , Vascular Stiffness*/physiology, Male ; Humans ; Female ; Young Adult ; Risk Factors ; Metabolomics/methods ; Histidine ; Pyrrolidonecarboxylic Acid ; Pulse Wave Analysis/adverse effects ; Amino Acids, Branched-Chain ; Heart Disease Risk Factors ; Threonine
مستخلص: Introduction: Increased exposure to risk factors in the young and healthy contributes to arterial changes, which may be accompanied by an altered metabolism.
Objectives: To increase our understanding of early metabolic alterations and how they associate with markers of arterial stiffness, we profiled urinary metabolites in young adults with cardiovascular disease (CVD) risk factor(s) and in a control group without CVD risk factors.
Methods: We included healthy black and white women and men (N = 1202), aged 20-30 years with a detailed CVD risk factor profile, reflecting obesity, physical inactivity, smoking, excessive alcohol intake, masked hypertension, hyperglycemia, dyslipidemia and low socio-economic status, forming the CVD risk group (N = 1036) and the control group (N = 166). Markers of arterial stiffness, central systolic blood pressure (BP) and pulse wave velocity were measured. A targeted metabolomics approach was followed by measuring amino acids and acylcarnitines using a liquid chromatography-tandem mass spectrometry method.
Results: In the CVD risk group, central systolic BP (adjusted for age, sex, ethnicity) was negatively associated with histidine, arginine, asparagine, serine, glutamine, dimethylglycine, threonine, GABA, proline, methionine, pyroglutamic acid, aspartic acid, glutamic acid, branched chain amino acids (BCAAs) and butyrylcarnitine (all P ≤ 0.048). In the same group, pulse wave velocity (adjusted for age, sex, ethnicity, mean arterial pressure) was negatively associated with histidine, lysine, threonine, 2-aminoadipic acid, BCAAs and aromatic amino acids (AAAs) (all P ≤ 0.044). In the control group, central systolic BP was negatively associated with pyroglutamic acid, glutamic acid and dodecanoylcarnitine (all P ≤ 0.033).
Conclusion: In a group with increased CVD risk, markers of arterial stiffness were negatively associated with metabolites related to AAA and BCAA as well as energy metabolism and oxidative stress. Our findings may suggest that metabolic adaptations may be at play in response to increased CVD risk to maintain cardiovascular integrity.
(© 2023. The Author(s).)
References: Prz Gastroenterol. 2016;11(2):78-89. (PMID: 27350834)
Auton Neurosci. 2015 Sep;191:48-66. (PMID: 26004513)
Signal Transduct Target Ther. 2021 Apr 28;6(1):162. (PMID: 33907179)
Pharmacol Res. 2018 Mar;129:95-99. (PMID: 29127059)
Nutrients. 2020 Mar 22;12(3):. (PMID: 32235743)
J Hypertens. 2015 Apr;33(4):791-6; discussion 796. (PMID: 25490711)
J Am Coll Cardiol. 2008 Jul 8;52(2):117-23. (PMID: 18598890)
Nutr J. 2015 Jan 10;14:6. (PMID: 25577237)
J Pharm Biomed Anal. 2015 Sep 10;113:121-36. (PMID: 25958299)
Int J Hypertens. 2013;2013:653789. (PMID: 23533715)
Cell. 2012 Apr 13;149(2):274-93. (PMID: 22500797)
Adv Pharmacol. 2013;68:13-21. (PMID: 24054138)
Int J Environ Res Public Health. 2016 Dec 14;13(12):. (PMID: 27983665)
J Hypertens. 2022 Aug 1;40(8):1545-1555. (PMID: 35788095)
Int J Biochem Cell Biol. 2015 Oct;67:158-66. (PMID: 26117455)
Front Mol Biosci. 2020 Feb 07;7:12. (PMID: 32118038)
Am J Hypertens. 2010 May;23(5):488-94. (PMID: 20134406)
Eur J Prev Cardiol. 2019 Mar;26(5):458-470. (PMID: 30681377)
Front Immunol. 2021 Sep 23;12:731701. (PMID: 34630411)
J Biol Chem. 2016 Oct 21;291(43):22414-22426. (PMID: 27587390)
Food Funct. 2016 Mar;7(3):1251-65. (PMID: 26797090)
Indian J Pediatr. 2012 Mar;79(3):395-6. (PMID: 21761123)
Cell Biochem Biophys. 2014 Apr;68(3):475-8. (PMID: 24068518)
Sci Rep. 2019 Jan 14;9(1):115. (PMID: 30643157)
Am J Hypertens. 2019 May 9;32(6):547-556. (PMID: 30953049)
Alcohol Res. 2017;38(2):219-241. (PMID: 28988575)
Rev Esp Cardiol (Engl Ed). 2013 Aug;66(8):657-61. (PMID: 24776335)
Nutrients. 2019 Sep 04;11(9):. (PMID: 31487814)
J Hypertens. 2019 Jun;37(6):1157-1166. (PMID: 30801385)
Neurotoxicol Teratol. 2011 Sep-Oct;33(5):538-47. (PMID: 21763768)
J Hypertens. 2012 Mar;30(3):445-8. (PMID: 22278144)
Crit Care Clin. 2020 Apr;36(2):307-321. (PMID: 32172815)
J Hypertens. 2013 Jul;31(7):1281-357. (PMID: 23817082)
Korean J Pediatr. 2016 Nov;59(11):425-431. (PMID: 27895689)
Arch Biochem Biophys. 2016 Aug 1;603:48-53. (PMID: 27173735)
J Amino Acids. 2012;2012:736837. (PMID: 22500213)
Blood Press Monit. 2006 Oct;11(5):293-6. (PMID: 16932038)
Alcohol Alcohol. 2006 Sep-Oct;41(5):522-7. (PMID: 16855003)
Sci Immunol. 2019 Jun 28;4(36):. (PMID: 31253642)
Circ Res. 2018 Apr 27;122(9):1238-1258. (PMID: 29700070)
Mutat Res. 2007 Jul 10;631(1):55-61. (PMID: 17499011)
Diabetol Metab Syndr. 2019 Aug 28;11:74. (PMID: 31467596)
Diab Vasc Dis Res. 2018 Jan;15(1):74-80. (PMID: 28976207)
J Nutr. 2006 Jun;136(6 Suppl):1722S-1725S. (PMID: 16702346)
Lancet Glob Health. 2019 Jun;7(6):e748-e760. (PMID: 31028013)
Prim Care. 2013 Mar;40(1):195-211. (PMID: 23402469)
J Cardiovasc Dev Dis. 2019 Apr 27;6(2):. (PMID: 31035613)
Hypertension. 2015 Sep;66(3):698-722. (PMID: 26160955)
Food Sci Nutr. 2020 Aug 12;8(9):4696-4707. (PMID: 32994931)
Circulation. 2018 May 15;137(20):2166-2178. (PMID: 29760227)
J Clin Diagn Res. 2016 Mar;10(3):ZE04-6. (PMID: 27135020)
Egypt J Basic Clin Pharmacol. 2019;9:. (PMID: 31105983)
Cureus. 2019 Jul 24;11(7):e5229. (PMID: 31565630)
Cell Mol Life Sci. 2017 Aug;74(16):2899-2916. (PMID: 28314892)
Hypertension. 2001 Oct;38(4):932-7. (PMID: 11641312)
J Am Coll Cardiol. 2016 Dec 27;68(25):2850-2870. (PMID: 28007146)
Hypertension. 2018 Nov;72(5):1200-1207. (PMID: 30354812)
Hypertens Res. 2015 Dec;38(12):840-6. (PMID: 26134123)
Front Mol Biosci. 2019 Feb 08;6:3. (PMID: 30800661)
BMC Med. 2019 Jul 3;17(1):128. (PMID: 31266500)
Hypertension. 2019 Aug;74(2):218-228. (PMID: 31203728)
J Cell Mol Med. 2018 Oct;22(10):4948-4962. (PMID: 30063118)
Trends Cardiovasc Med. 2011 Jul;21(5):151-5. (PMID: 22732551)
Biomark Insights. 2016 Jul 03;11:95-104. (PMID: 27398023)
J Obes. 2018 Nov 1;2018:8370304. (PMID: 30515323)
Purinergic Signal. 2023 Mar;19(1):265-272. (PMID: 34981330)
Ann Endocrinol (Paris). 2021 Jun;82(3-4):193-197. (PMID: 32473788)
Transl Med UniSa. 2011 Oct 17;1:213-28. (PMID: 23905034)
Sci Rep. 2020 Jun 23;10(1):10128. (PMID: 32576856)
Circ Res. 2018 Feb 2;122(3):489-505. (PMID: 29420210)
JRSM Cardiovasc Dis. 2017 Jan 01;6:2048004016687211. (PMID: 28286646)
Circ Res. 2019 Mar;124(5):799-815. (PMID: 30817262)
Nutr J. 2016 Jun 22;15(1):62. (PMID: 27334005)
Int J Environ Res Public Health. 2019 Oct 26;16(21):. (PMID: 31717742)
J Pharmacol Sci. 2015 Oct;129(2):83-94. (PMID: 26499181)
Hypertension. 2020 Nov;76(5):1616-1624. (PMID: 32895017)
معلومات مُعتمدة: MC_PC_16095 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: Arterial stiffness; Cardiovascular disease; Central systolic blood pressure; Metabolomics; Pulse wave velocity; Risk factors
المشرفين على المادة: 4QD397987E (Histidine)
SZB83O1W42 (Pyrrolidonecarboxylic Acid)
0 (acylcarnitine)
0 (Amino Acids, Branched-Chain)
2ZD004190S (Threonine)
تواريخ الأحداث: Date Created: 20230329 Date Completed: 20230331 Latest Revision: 20240425
رمز التحديث: 20240425
مُعرف محوري في PubMed: PMC10060307
DOI: 10.1007/s11306-023-01987-y
PMID: 36988718
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-3890
DOI:10.1007/s11306-023-01987-y