دورية أكاديمية
Markers of arterial stiffness and urinary metabolomics in young adults with early cardiovascular risk: the African-PREDICT study.
العنوان: | Markers of arterial stiffness and urinary metabolomics in young adults with early cardiovascular risk: the African-PREDICT study. |
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المؤلفون: | du Toit WL; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa., Kruger R; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Gafane-Matemane LF; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa., Schutte AE; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa.; School of Population Health, University of New South Wales, Sydney, Australia.; The George Institute for Global Health, Sydney, Australia., Louw R; Human Metabolomics, North-West University, Potchefstroom Campus, Potchefstroom, South Africa., Mels CMC; Hypertension in Africa Research Team (HART), North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa. carina.mels@nwu.ac.za.; MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. carina.mels@nwu.ac.za. |
المصدر: | Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2023 Mar 29; Vol. 19 (4), pp. 28. Date of Electronic Publication: 2023 Mar 29. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 101274889 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-3890 (Electronic) Linking ISSN: 15733882 NLM ISO Abbreviation: Metabolomics Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: New York : Springer, c2006- |
مواضيع طبية MeSH: | Cardiovascular Diseases* , Vascular Stiffness*/physiology, Male ; Humans ; Female ; Young Adult ; Risk Factors ; Metabolomics/methods ; Histidine ; Pyrrolidonecarboxylic Acid ; Pulse Wave Analysis/adverse effects ; Amino Acids, Branched-Chain ; Heart Disease Risk Factors ; Threonine |
مستخلص: | Introduction: Increased exposure to risk factors in the young and healthy contributes to arterial changes, which may be accompanied by an altered metabolism. Objectives: To increase our understanding of early metabolic alterations and how they associate with markers of arterial stiffness, we profiled urinary metabolites in young adults with cardiovascular disease (CVD) risk factor(s) and in a control group without CVD risk factors. Methods: We included healthy black and white women and men (N = 1202), aged 20-30 years with a detailed CVD risk factor profile, reflecting obesity, physical inactivity, smoking, excessive alcohol intake, masked hypertension, hyperglycemia, dyslipidemia and low socio-economic status, forming the CVD risk group (N = 1036) and the control group (N = 166). Markers of arterial stiffness, central systolic blood pressure (BP) and pulse wave velocity were measured. A targeted metabolomics approach was followed by measuring amino acids and acylcarnitines using a liquid chromatography-tandem mass spectrometry method. Results: In the CVD risk group, central systolic BP (adjusted for age, sex, ethnicity) was negatively associated with histidine, arginine, asparagine, serine, glutamine, dimethylglycine, threonine, GABA, proline, methionine, pyroglutamic acid, aspartic acid, glutamic acid, branched chain amino acids (BCAAs) and butyrylcarnitine (all P ≤ 0.048). In the same group, pulse wave velocity (adjusted for age, sex, ethnicity, mean arterial pressure) was negatively associated with histidine, lysine, threonine, 2-aminoadipic acid, BCAAs and aromatic amino acids (AAAs) (all P ≤ 0.044). In the control group, central systolic BP was negatively associated with pyroglutamic acid, glutamic acid and dodecanoylcarnitine (all P ≤ 0.033). Conclusion: In a group with increased CVD risk, markers of arterial stiffness were negatively associated with metabolites related to AAA and BCAA as well as energy metabolism and oxidative stress. Our findings may suggest that metabolic adaptations may be at play in response to increased CVD risk to maintain cardiovascular integrity. (© 2023. The Author(s).) |
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معلومات مُعتمدة: | MC_PC_16095 United Kingdom MRC_ Medical Research Council |
فهرسة مساهمة: | Keywords: Arterial stiffness; Cardiovascular disease; Central systolic blood pressure; Metabolomics; Pulse wave velocity; Risk factors |
المشرفين على المادة: | 4QD397987E (Histidine) SZB83O1W42 (Pyrrolidonecarboxylic Acid) 0 (acylcarnitine) 0 (Amino Acids, Branched-Chain) 2ZD004190S (Threonine) |
تواريخ الأحداث: | Date Created: 20230329 Date Completed: 20230331 Latest Revision: 20240425 |
رمز التحديث: | 20240425 |
مُعرف محوري في PubMed: | PMC10060307 |
DOI: | 10.1007/s11306-023-01987-y |
PMID: | 36988718 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-3890 |
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DOI: | 10.1007/s11306-023-01987-y |