دورية أكاديمية
Comprehensive Analysis of Donor Factors for Allograft Survival in Living Kidney Transplantation: A Single-Center Study in Japan.
| العنوان: | Comprehensive Analysis of Donor Factors for Allograft Survival in Living Kidney Transplantation: A Single-Center Study in Japan. |
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| المؤلفون: | Tomizawa M; Department of Urology, Nara Medical University, Nara, Japan., Hori S; Department of Urology, Nara Medical University, Nara, Japan., Nishimura N; Department of Urology, Nara Medical University, Nara, Japan., Omori C; Department of Urology, Nara Medical University, Nara, Japan., Nakai Y; Department of Urology, Nara Medical University, Nara, Japan., Miyake M; Department of Urology, Nara Medical University, Nara, Japan., Torimoto K; Department of Urology, Nara Medical University, Nara, Japan., Yoneda T; Department of Urology, Nara Medical University, Nara, Japan., Fujimoto K; Department of Urology, Nara Medical University, Nara, Japan. Electronic address: kiyokun@naramed-u.ac.jp. |
| المصدر: | Transplantation proceedings [Transplant Proc] 2023 May; Vol. 55 (4), pp. 737-743. Date of Electronic Publication: 2023 Mar 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 0243532 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2623 (Electronic) Linking ISSN: 00411345 NLM ISO Abbreviation: Transplant Proc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, N.Y. : Elsevier Science Inc. Original Publication: New York Stratton. |
| مواضيع طبية MeSH: | Kidney Transplantation*/adverse effects, Humans ; Retrospective Studies ; Japan ; Living Donors ; Graft Survival ; Graft Rejection ; Allografts |
| مستخلص: | Background: Various donor characteristics have been reported as predictive factors for graft survival in kidney transplantations. The living kidney donor profile index (LKDPI) was established in 2016 to evaluate the quality of living donor kidneys. Herein, we verified whether the index score was associated with graft survival and analyzed various donor factors to identify predictors of graft survival in living donor kidney transplantations. Methods: This retrospective study included 130 patients who received a living donor kidney between 2006 and 2019 at our hospital. Clinical and laboratory data were obtained from the medical records. Living donor kidneys were categorized into 3 groups by LKDPI score, and the death-censored graft survival and predictors of graft survival were evaluated. Results: The median LKDPI score was 35 (IQR: 17-53). The index scores of the living donor kidneys in this study were higher than in previous studies. The groups with the highest scores (LKDPI >40) had significantly shorter death-censored graft survival compared with the group with the lowest scores (LKDPI <20; hazard ratio = 4.0, P = .005). There were no significant differences between the group with the middle scores (LKDPI, 20-40) and the other 2 groups. Donor/recipient weight ratio <0.9, ABO incompatibility, and 2 HLA-DR mismatches were identified as independent predictive factors for shorter graft survival. Conclusion: The LKDPI was correlated with death-censored graft survival in this study. However, more studies are required to establish a modified index that is more accurate for Japanese patients. Competing Interests: DISCLOSURES The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023. Published by Elsevier Inc.) |
| تواريخ الأحداث: | Date Created: 20230329 Date Completed: 20230612 Latest Revision: 20230612 |
| رمز التحديث: | 20230612 |
| DOI: | 10.1016/j.transproceed.2023.01.030 |
| PMID: | 36990885 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-2623 |
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| DOI: | 10.1016/j.transproceed.2023.01.030 |