دورية أكاديمية
HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer.
| العنوان: | HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer. |
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| المؤلفون: | Raju GSR; Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul, 04620, Republic of Korea., Pavitra E; NanoBio High-Tech Materials Research Center, Biological Sciences and Bioengineering, Inha University, Incheon, 22212, Republic of Korea., Bandaru SS; Baton Rouge General Hospital, Baton Rouge, LA-70809, USA., Varaprasad GL; NanoBio High-Tech Materials Research Center, Biological Sciences and Bioengineering, Inha University, Incheon, 22212, Republic of Korea., Nagaraju GP; School of Medicine, Division of Hematology and Oncology, University of Alabama, Birmingham, AL, 35233, USA. pganji@uab.edu., Malla RR; Cancer Biology Laboratory, Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, 530045, India. dr.rrmalla@gmail.com., Huh YS; NanoBio High-Tech Materials Research Center, Biological Sciences and Bioengineering, Inha University, Incheon, 22212, Republic of Korea. yunsuk.huh@inha.ac.kr., Han YK; Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul, 04620, Republic of Korea. ykenergy@dongguk.edu. |
| المصدر: | Molecular cancer [Mol Cancer] 2023 Mar 30; Vol. 22 (1), pp. 65. Date of Electronic Publication: 2023 Mar 30. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, c2002- |
| مواضيع طبية MeSH: | Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , RNA, Long Noncoding*/genetics, Female ; Humans ; Gene Expression Regulation, Neoplastic ; Prognosis |
| مستخلص: | HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications. (© 2023. The Author(s).) |
| References: | J Cell Biochem. 2020 Feb;121(2):1736-1746. (PMID: 31595577) Acta Biochim Biophys Sin (Shanghai). 2014 Dec;46(12):1011-5. (PMID: 25385164) Int J Cancer. 2019 Nov 1;145(9):2478-2487. (PMID: 30963568) Theranostics. 2019 Jun 24;9(16):4608-4623. (PMID: 31367244) Front Mol Biosci. 2022 Oct 28;9:1032517. (PMID: 36387279) Mol Cancer. 2017 Jul 24;16(1):129. (PMID: 28738804) Int J Mol Sci. 2022 Oct 04;23(19):. (PMID: 36233075) Int J Oncol. 2017 Apr;50(4):1271-1278. (PMID: 28350082) J Cell Biochem. 2019 May;120(5):7056-7067. (PMID: 30484890) Phytomedicine. 2020 Apr 16;70:153227. (PMID: 32339885) Exp Ther Med. 2019 Jul;18(1):435-442. (PMID: 31281438) Front Oncol. 2021 Nov 17;11:783211. (PMID: 34869037) Breast. 2019 Aug;46:64-69. (PMID: 31100572) J Cancer Prev. 2021 Sep 30;26(3):183-194. (PMID: 34703821) Technol Cancer Res Treat. 2019 Jan-Dec;18:1533033819882949. (PMID: 31672084) Int J Mol Sci. 2017 Nov 03;18(11):. (PMID: 29469819) Cell J. 2020 Jul;22(2):178-184. (PMID: 31721532) Oncol Lett. 2019 Oct;18(4):3817-3822. (PMID: 31516593) Cell Signal. 2017 Feb;31:87-95. (PMID: 28069441) J Transl Med. 2020 Apr 3;18(1):152. (PMID: 32245498) Mol Cancer. 2019 Apr 3;18(1):78. (PMID: 30943982) Gene. 2019 Sep 25;714:143955. (PMID: 31326549) Oncotarget. 2016 Jan 26;7(4):4712-23. (PMID: 26717040) Acta Biochim Biophys Sin (Shanghai). 2022 Dec 26;:. (PMID: 36647722) Front Oncol. 2021 Nov 04;11:752270. (PMID: 34804940) Tumour Biol. 2015 May;36(5):3611-9. (PMID: 25547435) Biochem Biophys Rep. 2022 May 18;30:101279. (PMID: 35619625) Mol Carcinog. 2015 Dec;54(12):1656-67. (PMID: 25328122) DNA Repair (Amst). 2021 Sep;105:103141. (PMID: 34183273) Cancer Med. 2018 Mar;7(3):842-855. (PMID: 29473328) PLoS One. 2017 Jan 25;12(1):e0170860. (PMID: 28122024) Sci Rep. 2017 Dec 8;7(1):17261. (PMID: 29222472) J Steroid Biochem Mol Biol. 2014 May;141:160-70. (PMID: 24533973) Br J Cancer. 2021 Jan;124(1):247-258. (PMID: 33024272) Biomolecules. 2021 Feb 18;11(2):. (PMID: 33670447) Tumour Biol. 2015 May;36(5):3863-70. (PMID: 25586347) Cancer Biol Ther. 2005 Nov;4(11):1248-54. (PMID: 16258257) J Gene Med. 2020 Dec;22(12):e3271. (PMID: 32889751) Cancer Biomark. 2018;22(2):249-256. (PMID: 29630518) Crit Rev Eukaryot Gene Expr. 2020;30(5):447-456. (PMID: 33389881) Mol Cancer. 2018 Jan 11;17(1):5. (PMID: 29325547) BMC Cancer. 2016 Jul 07;16:423. (PMID: 27388461) Stem Cells. 2014 Nov;32(11):2858-68. (PMID: 25070049) Breast Cancer Res Treat. 2012 Dec;136(3):875-83. (PMID: 23124417) Open Med (Wars). 2016 Mar 10;11(1):36-40. (PMID: 28352764) J Transl Med. 2018 Sep 27;16(1):264. (PMID: 30261893) J Cell Biochem. 2019 Jun;120(6):10548-10555. (PMID: 30635945) Acta Biochim Biophys Sin (Shanghai). 2014 Jan;46(1):1-5. (PMID: 24165275) Neoplasma. 2014;61(4):379-91. (PMID: 25027739) Cancer Epidemiol. 2015 Dec;39(6):978-85. (PMID: 26547792) Front Oncol. 2021 Jul 12;11:706428. (PMID: 34322392) Biomed Pharmacother. 2017 Jun;90:555-561. (PMID: 28407576) Cell Death Dis. 2020 Sep 19;11(9):780. (PMID: 32951010) Int J Gen Med. 2021 Aug 18;14:4653-4663. (PMID: 34434057) Nature. 2010 Apr 15;464(7291):1071-6. (PMID: 20393566) Oncol Lett. 2017 Mar;13(3):1143-1148. (PMID: 28454226) Mol Oncol. 2019 May;13(5):1137-1149. (PMID: 30803129) Cell Death Differ. 2019 May;26(5):890-901. (PMID: 30154449) Cancer Biol Med. 2015 Mar;12(1):1-9. (PMID: 25859406) Cell Physiol Biochem. 2018;47(3):893-913. (PMID: 29843138) Hered Cancer Clin Pract. 2022 Jan 29;20(1):4. (PMID: 35093153) BMC Complement Altern Med. 2016 Sep 30;16(1):383. (PMID: 27751178) Inflammation. 2021 Aug;44(4):1452-1463. (PMID: 33665757) Cancer Biomark. 2021;30(2):203-212. (PMID: 33104019) J Transl Med. 2015 Apr 25;13:131. (PMID: 25928008) Sci Rep. 2017 Apr 18;7(1):894. (PMID: 28420874) Oncogene. 2022 Jan;41(1):99-111. (PMID: 34697449) Clin Epigenetics. 2019 Feb 14;11(1):29. (PMID: 30764859) Cancer Sci. 2019 Oct;110(10):3089-3097. (PMID: 31325197) Noncoding RNA Res. 2018 Mar 31;3(3):108-117. (PMID: 30175284) Sci Rep. 2022 Jan 27;12(1):1513. (PMID: 35087108) Thorac Cancer. 2020 Jul;11(7):1801-1816. (PMID: 32374522) J Mol Med (Berl). 2020 Nov;98(11):1525-1546. (PMID: 32978667) Cancer Cell Int. 2020 Jul 17;20:320. (PMID: 32694942) Am J Cancer Res. 2021 Mar 01;11(3):945-954. (PMID: 33791165) PLoS Biol. 2022 Nov 28;20(11):e3001885. (PMID: 36441764) Front Oncol. 2020 Oct 08;10:579940. (PMID: 33134177) J Med Biochem. 2021 Jan 26;40(1):17-25. (PMID: 33584136) Iran Biomed J. 2021 Dec 20;26(1):77-84. (PMID: 34923813) Noncoding RNA. 2020 May 26;6(2):. (PMID: 32466537) Steroids. 2020 Dec;164:108729. (PMID: 32941921) Cancer Lett. 2019 Sep 28;460:18-28. (PMID: 31207321) Cell Physiol Biochem. 2015;35(2):722-8. (PMID: 25613518) J Mol Biol. 2013 Oct 9;425(19):3707-22. (PMID: 23375982) Tumour Biol. 2017 Oct;39(10):1010428317727539. (PMID: 29022495) Biopharm Drug Dispos. 2019 Feb;40(2):70-80. (PMID: 30698830) Bosn J Basic Med Sci. 2020 Feb 05;20(1):56-62. (PMID: 31319040) RNA. 2016 Jul;22(7):995-1010. (PMID: 27146324) Mol Cancer. 2014 Jun 23;13:156. (PMID: 24953832) Neuro Oncol. 2013 Dec;15(12):1595-603. (PMID: 24203894) Int J Med Sci. 2018 Aug 6;15(12):1312-1319. (PMID: 30275757) Cancer Res. 2016 Jan 15;76(2):293-304. (PMID: 26719542) Curr Drug Targets. 2018;19(10):1220-1226. (PMID: 28641521) J Cell Physiol. 2019 Aug;234(8):14019-14030. (PMID: 30618123) Mol Oncol. 2017 Dec;11(12):1698-1710. (PMID: 28846832) Breast Cancer Res Treat. 2015 Jul;152(1):199-208. (PMID: 26033707) J Cell Mol Med. 2020 May;24(10):5578-5592. (PMID: 32248643) Clin Cancer Res. 2018 Jun 1;24(11):2665-2677. (PMID: 29540490) Biochem J. 2018 Jan 15;475(1):355-371. (PMID: 29229759) Biochim Biophys Acta. 2014 Sep;1839(9):837-48. (PMID: 24999034) Front Immunol. 2021 Nov 23;12:785463. (PMID: 34887871) Oncotarget. 2015 May 10;6(13):11150-61. (PMID: 25883211) Biochim Biophys Acta. 2015 Aug;1856(1):151-64. (PMID: 26208723) J Cell Biochem. 2021 Apr;122(3-4):385-393. (PMID: 33164274) Nan Fang Yi Ke Da Xue Xue Bao. 2016 Apr;36(4):488-92. (PMID: 27113175) Protein Cell. 2016 Feb;7(2):89-99. (PMID: 26349457) Biosci Rep. 2019 Apr 5;39(4):. (PMID: 30429228) J Cancer. 2019 May 12;10(9):2018-2024. (PMID: 31205562) Life (Basel). 2021 May 26;11(6):. (PMID: 34073224) Gastric Cancer. 2020 Nov;23(6):1018-1032. (PMID: 32583079) J Transl Med. 2019 Dec 3;17(1):404. (PMID: 31796041) Mol Cancer. 2014 Apr 28;13:92. (PMID: 24775712) Gene. 2020 Dec 15;762:145033. (PMID: 32781191) Minerva Med. 2016 Dec;107(6):392-400. (PMID: 27333150) Clin Lab. 2020 Sep 1;66(9):. (PMID: 32902209) Invest Ophthalmol Vis Sci. 2021 Mar 1;62(3):20. (PMID: 33724292) DNA Cell Biol. 2020 Nov 2;:. (PMID: 33136445) Biochem Genet. 2022 Oct;60(5):1781-1792. (PMID: 35092560) Sci Rep. 2019 Dec 27;9(1):19881. (PMID: 31882666) Hum Mol Genet. 2016 Aug 1;25(15):3269-3283. (PMID: 27378691) EMBO J. 2013 May 29;32(11):1584-97. (PMID: 23624935) Stem Cells. 2013 Dec;31(12):2827-32. (PMID: 24022994) |
| معلومات مُعتمدة: | 2021R1F1A1064174 National Research Foundation of Korea; 2021R1A5A6002853 National Research Foundation of Korea; 2020R1A4A3079710 National Research Foundation of Korea |
| فهرسة مساهمة: | Keywords: Breast cancer; Drug resistance; HOTAIR; Metastasis; Prognosis |
| المشرفين على المادة: | 0 (RNA, Long Noncoding) 0 (HOTAIR long untranslated RNA, human) |
| تواريخ الأحداث: | Date Created: 20230330 Date Completed: 20230403 Latest Revision: 20230413 |
| رمز التحديث: | 20230413 |
| مُعرف محوري في PubMed: | PMC10061914 |
| DOI: | 10.1186/s12943-023-01765-3 |
| PMID: | 36997931 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1476-4598 |
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| DOI: | 10.1186/s12943-023-01765-3 |