دورية أكاديمية
Antimicrobial photodynamic in vitro inactivation of Enterococcus spp. and Staphylococcus spp. strains using tetra-cationic platinum(II) porphyrins.
| العنوان: | Antimicrobial photodynamic in vitro inactivation of Enterococcus spp. and Staphylococcus spp. strains using tetra-cationic platinum(II) porphyrins. |
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| المؤلفون: | Pinheiro TDR; Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia - LAPEMICRO, Universidade Federal de Santa Maria, RS, Brazil., Urquhart CG; Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia - LAPEMICRO, Universidade Federal de Santa Maria, RS, Brazil., Acunha TV; Laboratório de Bioinorgânica e Materiais Porfirínicos (LBMP), Departamento de Química, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil., Santos RCV; Programa de Pós-Graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia - LAPEMICRO, Universidade Federal de Santa Maria, RS, Brazil. Electronic address: robertochrist@gmail.com., Iglesias BA; Laboratório de Bioinorgânica e Materiais Porfirínicos (LBMP), Departamento de Química, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil. Electronic address: bernardo.iglesias@ufsm.br. |
| المصدر: | Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2023 Jun; Vol. 42, pp. 103542. Date of Electronic Publication: 2023 Mar 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101226123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1597 (Electronic) Linking ISSN: 15721000 NLM ISO Abbreviation: Photodiagnosis Photodyn Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; Boston : Elsevier, c2004- |
| مواضيع طبية MeSH: | Photochemotherapy*/methods , Porphyrins*/pharmacology , Anti-Infective Agents*, Platinum/pharmacology ; Photosensitizing Agents/pharmacology ; Enterococcus ; Staphylococcus ; Anti-Bacterial Agents/pharmacology ; Bacteria |
| مستخلص: | This manuscript presents the first report on antimicrobial photo-inactivation in vitro using tetra-cationic porphyrins with peripheral platinum(II) bipyridyl complexes against Gram-positive bacteria. Two isomeric tetra-cationic porphyrins (3TPyP and 4TPyP) were tested against clinically important bacterial species. The antimicrobial activity assays were performed at specific photosensitizer (PS) concentrations under dark and white-light LED irradiation conditions for 120 min. The porphyrin 3-PtTPyP was the most efficient PS against the bacteria tested, inhibiting bacterial growth in just 15 min and 30 min at low concentrations (3.75 and 0.45 µM). The minimal inhibitory concentration of the porphyrin increased in the presence of reactive oxygen species scavengers, indicating that singlet oxygen and radical species likely participated in the photo-oxidation mechanism. In addition, the checkerboard assay that tests the association of compounds, showed a synergistic effect, suggesting a potentiation of the antibacterial effect when porphyrin was tested in combination with ciprofloxacin and vancomycin. Thus, tetra-cationic porphyrins containing platinum(II) complexes are promising agents for microbial photo-inactivation as an alternative therapy against infections. Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antimicrobial activity; Cationic porphyrins; Gram-positive bacteria; Photodynamic therapy; Pt(II) porphyrins |
| المشرفين على المادة: | 49DFR088MY (Platinum) 0 (Photosensitizing Agents) 0 (Porphyrins) 0 (Anti-Infective Agents) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20230401 Date Completed: 20230703 Latest Revision: 20230703 |
| رمز التحديث: | 20230703 |
| DOI: | 10.1016/j.pdpdt.2023.103542 |
| PMID: | 37003596 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-1597 |
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| DOI: | 10.1016/j.pdpdt.2023.103542 |