دورية أكاديمية
Chemical characterization of Brazilian savannah Byrsonima species (muricis) and their impact on genomic instability and chemopreventive effects.
| العنوان: | Chemical characterization of Brazilian savannah Byrsonima species (muricis) and their impact on genomic instability and chemopreventive effects. |
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| المؤلفون: | Specian AFL; Department of General Biology, State University of Londrina, Londrina 86057-970, Brazil., Tuttis K; Department of General Biology, State University of Londrina, Londrina 86057-970, Brazil., Serpeloni JM; Department of General Biology, State University of Londrina, Londrina 86057-970, Brazil., Ribeiro DL; Department of General Biology, State University of Londrina, Londrina 86057-970, Brazil., Nunes HL; Department of General Biology, State University of Londrina, Londrina 86057-970, Brazil., Tangerina MMP; Department of Chemistry, São Paulo State University 'Júlio de Mesquita Filho', 14801-970, Brazil., Sannomiya M; School of Arts, Science, and Humanities, São Paulo University, São Paulo 03828-000, Brazil., Varanda EA; Department of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, São Paulo State University 'Júlio de Mesquita Filho', Araraquara 14800-900, Brazil., Vilegas W; Institute of Biosciences, São Paulo State University, Campus São Vicente 11330-900, Brazil., Cólus IMS; Department of General Biology, State University of Londrina, Londrina 86057-970, Brazil. Electronic address: ilcecolus@gmail.com. |
| المصدر: | Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2023 Apr; Vol. 887, pp. 503586. Date of Electronic Publication: 2023 Jan 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101632149 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3592 (Electronic) Linking ISSN: 13835718 NLM ISO Abbreviation: Mutat Res Genet Toxicol Environ Mutagen Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, 1997- |
| مواضيع طبية MeSH: | Anticarcinogenic Agents* , Antimutagenic Agents*/pharmacology, Humans ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Brazil ; Plants ; Antioxidants/pharmacology ; Mutagens/toxicity ; Genomic Instability |
| مستخلص: | The identification of new drugs with few or no adverse effects is of great interest worldwide. In cancer therapy, natural products have been used as chemopreventive and chemotherapeutic agents. Plants from the Brazilian savannah belonging to the Byrsonima genus are popularly known as muricis and have attracted much attention due to their various pharmacological activities. However, there are currently no data on these plants concerning their use as chemopreventive or chemotherapeutic agents in human cell lines. The present study assessed the potential of B. correifolia, B. verbascifolia, B. crassifolia, and B. intermedia extracts as natural alternatives in the prevention and/or treatment of cancer. The chemical constituents present in each extract were analyzed by electrospray ionization-mass spectrometry (ESI-MSN). The mutagenic/antimutagenic (micronucleus assay), genotoxic/antigenotoxic (comet assay), apoptotic/necrotic (acridine orange/ethidium bromide uptake), and oxidative/antioxidative (CM-H Competing Interests: Conflict of interest None declared. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anticancer; Apoptosis; Medicinal plant; Mutagenesis; Phytochemicals; in vitro |
| المشرفين على المادة: | 0 (Plant Extracts) 0 (Antioxidants) 0 (Anticarcinogenic Agents) 0 (Mutagens) 0 (Antimutagenic Agents) |
| تواريخ الأحداث: | Date Created: 20230401 Date Completed: 20230404 Latest Revision: 20230404 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.mrgentox.2023.503586 |
| PMID: | 37003647 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3592 |
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| DOI: | 10.1016/j.mrgentox.2023.503586 |