دورية أكاديمية
Transfluthrin- and prallethrin-based insecticides elicit specific enzymatic antioxidant responses in different tissue of zebrafish.
| العنوان: | Transfluthrin- and prallethrin-based insecticides elicit specific enzymatic antioxidant responses in different tissue of zebrafish. |
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| المؤلفون: | Tamagno WA; Graduate Program in Pharmacology, Universidade Federal de Santa Maria Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil; Biochemistry and Molecular Biology Laboratory, Rosilene Rodrigues Kaizer, Federal Institute of Education, Science and Technology of Rio Grande do Sul, Campus Sertão, ERS 135, km 25, Eng. English, RS, 99170-000, Brazil. Electronic address: wagner.tamagno@sertao.ifrs.edu.br., Alves C; Biochemistry and Molecular Biology Laboratory, Rosilene Rodrigues Kaizer, Federal Institute of Education, Science and Technology of Rio Grande do Sul, Campus Sertão, ERS 135, km 25, Eng. English, RS, 99170-000, Brazil. Electronic address: carla.alves@sertao.ifrs.edu.br., Pompermaier A; Graduate Program in Bioexperimentation Universidade de Passo Fundo, BR 285, São José, Passo Fundo, RS, 99052-900, Brazil. Electronic address: 171899@upf.br., Veneral AL; Graduate Program in Bioexperimentation Universidade de Passo Fundo, BR 285, São José, Passo Fundo, RS, 99052-900, Brazil. Electronic address: 189447@upf.br., Duarte Lampugnani JA; Graduate Program in Bioexperimentation Universidade de Passo Fundo, BR 285, São José, Passo Fundo, RS, 99052-900, Brazil. Electronic address: 130917@ufp.br., Reolon GK; Biochemistry and Molecular Biology Laboratory, Rosilene Rodrigues Kaizer, Federal Institute of Education, Science and Technology of Rio Grande do Sul, Campus Sertão, ERS 135, km 25, Eng. English, RS, 99170-000, Brazil. Electronic address: gustavo.reolon@sertao.ifrs.edu.br., Gil Barcellos LJ; Graduate Program in Pharmacology, Universidade Federal de Santa Maria Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil; Graduate Program in Bioexperimentation Universidade de Passo Fundo, BR 285, São José, Passo Fundo, RS, 99052-900, Brazil. Electronic address: lbarcellos@upf.br. |
| المصدر: | Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2023 Jun 15; Vol. 327, pp. 121530. Date of Electronic Publication: 2023 Mar 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987- |
| مواضيع طبية MeSH: | Insecticides*/toxicity , Pyrethrins*/toxicity, Animals ; Humans ; Antioxidants/metabolism ; Zebrafish/metabolism ; Oxidative Stress ; Lipid Peroxidation |
| مستخلص: | Pyrethroids prallethrin (P-BI) and transfluthrin (T-BI) are among the most commonly used molecules with insecticide action. These molecules comprise different formulations of insecticides largely used in household, agricultural, and animal production fields. However, the increased use of these molecules has led to concerns regarding their safety in animals and humans. Oxidative stress (OS) is believed to be easily established by xenobiotic contacts, such as pyrethroids. We aimed to evaluate and understand the impact of two household insecticides and two doses applied to different tissues of the antioxidant system of zebrafish (Danio rerio). We observed that the effect on the antioxidant system differed between tissues. The muscle was the most affected tissue in the body, the antioxidant enzymes were activated, and a mechanism of non-enzymatic antioxidants was activated; however, it could still cause cellular damage. The observed effect on muscle may be related to the progression of neurodegenerative conditions. In addition, in the brain, these compounds can inactivate the first line of enzymatic antioxidant defense, which is compensated for by the second line, avoiding cellular damage. Ultimately, the gill tissue did not appear to suffer lipid damage, but heme group formation was largely affected by the compounds. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antioxidant enzymes; Cellular damage; Lipid peroxidation; Nonprotein thiols; Porphobilinogen; Pyrethroids |
| المشرفين على المادة: | 0 (Insecticides) 23031-36-9 (d,d-T80-prallethrin) 0 (Antioxidants) QWL3SKA6EG (transfluthrin) 0 (Pyrethrins) |
| تواريخ الأحداث: | Date Created: 20230402 Date Completed: 20230427 Latest Revision: 20230427 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.envpol.2023.121530 |
| PMID: | 37004863 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6424 |
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| DOI: | 10.1016/j.envpol.2023.121530 |