دورية أكاديمية
Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury?
| العنوان: | Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury? |
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| المؤلفون: | Papas KK; Institute for Cellular Transplantation, University of Arizona, Tucson, AZ, USA.; Procyon Technologies LLC, Tucson, AZ, USA., Putnam CW; Institute for Cellular Transplantation, University of Arizona, Tucson, AZ, USA., Johnson RC; Institute for Cellular Transplantation, University of Arizona, Tucson, AZ, USA.; Procyon Technologies LLC, Tucson, AZ, USA., Sambanis A; Georgia Institute of Technology, Atlanta, GA, USA. |
| المصدر: | Cell transplantation [Cell Transplant] 2023 Jan-Dec; Vol. 32, pp. 9636897231163233. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publishing Country of Publication: United States NLM ID: 9208854 Publication Model: Print Cited Medium: Internet ISSN: 1555-3892 (Electronic) Linking ISSN: 09636897 NLM ISO Abbreviation: Cell Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : Thousand Oaks, CA : SAGE Publishing Original Publication: Elmsford, New York : Pergamon Press, c1992- |
| مواضيع طبية MeSH: | Islets of Langerhans* , Islets of Langerhans Transplantation*/adverse effects , Hypoglycemia*/etiology , Hypoglycemia*/therapy , Diabetes Mellitus*, Humans ; Insulin ; Hypoglycemic Agents |
| مستخلص: | Transplants comprised of encapsulated islets have shown promise in treating insulin-dependent diabetes. A question raised in the scientific and clinical communities is whether the insulin released from an implanted encapsulation device damaged in an accident could cause a serious hypoglycemic event. In this commentary, we consider the different types of damage that a device can sustain, including the encapsulation membrane and the islets within, and the amount of insulin released in each case. We conclude that the probability that device damage would cause an adverse hypoglycemic event is indeed very low. |
| References: | ASAIO Trans. 1990 Jul-Sep;36(3):M715-9. (PMID: 2252792) Sci Rep. 2020 Jul 20;10(1):12009. (PMID: 32686715) Biotechnol Prog. 1995 Mar-Apr;11(2):115-26. (PMID: 7766095) Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19054-8. (PMID: 24167261) Mol Metab. 2021 Jun;48:101212. (PMID: 33737253) |
| معلومات مُعتمدة: | DP3 DK106933 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: encapsulated islets; encapsulation device damage; hypoglycemia |
| المشرفين على المادة: | 0 (Insulin) 0 (Hypoglycemic Agents) |
| تواريخ الأحداث: | Date Created: 20230403 Date Completed: 20230404 Latest Revision: 20230506 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10074617 |
| DOI: | 10.1177/09636897231163233 |
| PMID: | 37005727 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1555-3892 |
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| DOI: | 10.1177/09636897231163233 |