دورية أكاديمية
Hypochlorous Acid 0.01% vs Povidone-Iodine 5% for Ocular Antisepsis.
| العنوان: | Hypochlorous Acid 0.01% vs Povidone-Iodine 5% for Ocular Antisepsis. |
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| المؤلفون: | Hejkal TW; Eye Consultants PC, Omaha, NE, USA., Maloley LA; Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, NE, USA., Kaddoura L; Eye Consultants PC, Omaha, NE, USA. |
| المصدر: | Journal of vitreoretinal diseases [J Vitreoretin Dis] 2021 May 21; Vol. 6 (2), pp. 132-137. Date of Electronic Publication: 2021 May 21 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: United States NLM ID: 101700301 Publication Model: eCollection Cited Medium: Internet ISSN: 2474-1272 (Electronic) Linking ISSN: 24741264 NLM ISO Abbreviation: J Vitreoretin Dis Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Thousand Oaks, CA : Sage Publications, [2017]- |
| مستخلص: | Purpose: An alternative ocular antiseptic is needed for patients who do not tolerate povidone-iodine (PI). The purpose of this study is to compare the antimicrobial effect of hypochlorous acid (HA) 0.01% with PI 5% applied topically to the ocular surface. Methods: Swabs of the inferior conjunctiva and posterior lower eyelid margin of 40 patients were taken from both eyes and plated onto blood agar plates. One eye was treated with HA and the other with PI, and swabs were taken after 1-minute exposure. The eye treated with PI was rinsed with sterile saline and another swab was taken. Colony-forming units (CFUs) were recorded after 2 days. Patients rated the level of irritation after treatment in each eye. Results: HA and PI both gave significant reduction in CFUs from baseline ( P < .001 for HA and P = .002 for PI). The mean reduction in logCFU ± 95% CI was 0.850 ± 0.387 or greater for HA and 0.749 ± 0.385 or greater for PI; this was equivalent to a mean reduction of 7.1-fold or greater or 86% or greater (95% CI, 66%-94%) for HA and 5.6-fold or greater or 82% or greater (95% CI, 57%-93%) for PI. CFUs increased in 17 eyes after saline rinse. PI caused substantial irritation in 31 of the 40 participants, whereas no individuals had any irritation from topical HA. Conclusions: Both HA and PI were effective in reducing ocular bacterial load. Unlike PI, HA was not irritating to the eye. Saline rinse after topical PI may increase bacterial counts in some individuals. Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s) 2021.) |
| References: | Ophthalmology. 2016 Dec;123(12):2588-2594. (PMID: 27720552) Cornea. 2015 Dec;34(12):1599-605. (PMID: 26488624) BMC Ophthalmol. 2018 Jul 11;18(1):167. (PMID: 29996791) Biocontrol Sci. 2012;17(3):129-33. (PMID: 23007104) Mil Med. 1992 Mar;157(3):111-3. (PMID: 1603399) Acta Ophthalmol Scand. 2005 Jun;83(3):360-3. (PMID: 15948791) Cutan Ocul Toxicol. 2017 Dec;36(4):343-346. (PMID: 28166657) Br J Ophthalmol. 2003 Feb;87(2):163-7. (PMID: 12543744) Acta Ophthalmol. 2016 Dec;94(8):e808-e809. (PMID: 26947261) Retina. 2014 Dec;34 Suppl 12:S1-S18. (PMID: 25489719) J Burns Wounds. 2007 Apr 11;6:e6. (PMID: 17492051) Indian J Ophthalmol. 2020 Nov;68(11):2439-2444. (PMID: 33120635) Dermatol Surg. 2018 Dec;44(12):1489-1493. (PMID: 29985866) Am J Ophthalmol. 2011 Feb;151(2):329-32. (PMID: 21168821) Am J Vet Res. 1986 Jun;47(6):1207-10. (PMID: 3729119) Adv Skin Wound Care. 2014 Feb;27(2):65-9. (PMID: 24440863) J Burns Wounds. 2007 Apr 11;6:e5. (PMID: 17492050) Arch Ophthalmol. 1984 May;102(5):728-9. (PMID: 6721765) Optom Vis Sci. 2017 Jul;94(7):732-741. (PMID: 28609415) Retina. 2018 Oct;38(10):2064-2066. (PMID: 28796148) Retina. 2013 May;33(5):975-81. (PMID: 23416514) |
| فهرسة مساهمة: | Keywords: antisepsis; endophthalmitis; hypochlorous acid; intravitreal injection; povidone-iodine |
| تواريخ الأحداث: | Date Created: 20230403 Latest Revision: 20230404 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9976015 |
| DOI: | 10.1177/24741264211013622 |
| PMID: | 37008664 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2474-1272 |
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| DOI: | 10.1177/24741264211013622 |