دورية أكاديمية
Understanding the functional relevance of oral neutrophils, phenotype and properties in OSCC.
| العنوان: | Understanding the functional relevance of oral neutrophils, phenotype and properties in OSCC. |
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| المؤلفون: | Lenka S; Department of Medical Research, IMS and SUM Hospital, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, Odisha, India., Bhola RK; Department of Pathology, IMS and SUM Hospital, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, Odisha, India., Varanasi PR; Department of Medical Research, IMS and SUM Hospital, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, Odisha, India., Bhuyan SK; Department of Oral Medicine and Radiology, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, Odisha, India., Bhuyan R; Department of Medical Research, IMS and SUM Hospital, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, Odisha, India. ruchibhuyan@soa.ac.in.; Department of Oral Pathology and Microbiology, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be) University, Bhubaneswar, 751003, India. ruchibhuyan@soa.ac.in. |
| المصدر: | Medical oncology (Northwood, London, England) [Med Oncol] 2023 Apr 03; Vol. 40 (5), pp. 134. Date of Electronic Publication: 2023 Apr 03. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : New York : Springer Original Publication: Northwood, Middlesex, England : Science and Technology Letters, c1994- |
| مواضيع طبية MeSH: | Carcinoma, Squamous Cell*/pathology , Mouth Neoplasms*/pathology , Head and Neck Neoplasms*/pathology, Humans ; Neutrophils/pathology ; Squamous Cell Carcinoma of Head and Neck/pathology ; Ecosystem ; Inflammation/metabolism ; Phenotype |
| مستخلص: | Neutrophils are the predominant white blood cells (WBC) that are recruited to the sites of inflammation and infection. They are acknowledged to perform dual roles by promoting (pro-tumor) or by exhibiting anti-cancer properties (anti-tumor). Neutrophils are characterized based on the changes in phenotype and functional properties. To this context, circulating polymorphonuclear neutrophils (cPMN) and tumor-associated neutrophils (TANs) in cancer biology has been well explored but limited to oral polymorphonuclear neutrophils (oPMNs) in oral squamous cell carcinoma (OSCC). However, oPMNs are eminent in maintaining the healthy oral ecosystem by neutralizing microorganisms. Neutralization process enhances the expression of cell surface markers (CD11b, CD63, CD66, CD66b, CD66c, and CD66e) and inflammatory cytokines (TNF-α, IFN-γ, GM-CSF, and IL-8) and increases the recruitment of neutrophils. Along with the inflammation, it has been reported that CEACAM1 and chemerin also favors the infiltration of neutrophils to the cancer site. This indicates that oPMN might contribute to the aetiology of OSCC. The main objective of this review is to explore, the production and migration of oPMNs to the oral cavity, their phenotypes and possible role in OSCC. (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Chemokines; Circulating neutrophils; Cytokines; Oral cancer; Oral neutrophils; Surface markers |
| تواريخ الأحداث: | Date Created: 20230403 Date Completed: 20230405 Latest Revision: 20230427 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s12032-023-02010-z |
| PMID: | 37010645 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1559-131X |
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| DOI: | 10.1007/s12032-023-02010-z |