دورية أكاديمية
FGF4 and FGF9 have synergistic effects on odontoblast differentiation.
| العنوان: | FGF4 and FGF9 have synergistic effects on odontoblast differentiation. |
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| المؤلفون: | Hoshino T; Department of Dental Anesthesiology, Tokyo Dental College, Misaki-cho, Chiyoda-ku, Tokyo, Japan., Onodera S; Department of Biochemistry, Tokyo Dental College, 2-9-18, Kanda-Misakichou, Chiyoda-ku, Tokyo, 101-0061, Japan., Kimura M; Department of Pediatric Dentistry, Tokyo Dental College, Misaki-cho, Chiyoda-ku, Tokyo, Japan., Suematsu M; Department of Dental Biochemistry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan., Ichinohe T; Department of Dental Anesthesiology, Tokyo Dental College, Misaki-cho, Chiyoda-ku, Tokyo, Japan., Azuma T; Department of Biochemistry, Tokyo Dental College, 2-9-18, Kanda-Misakichou, Chiyoda-ku, Tokyo, 101-0061, Japan. tazuma@tdc.ac.jp. |
| المصدر: | Medical molecular morphology [Med Mol Morphol] 2023 Sep; Vol. 56 (3), pp. 159-176. Date of Electronic Publication: 2023 Apr 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Japan NLM ID: 101239023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-1499 (Electronic) Linking ISSN: 18601499 NLM ISO Abbreviation: Med Mol Morphol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo, Japan : Springer, [2005]- |
| مواضيع طبية MeSH: | Core Binding Factor Alpha 1 Subunit*/genetics , Fibroblast Growth Factor 4*/genetics , Fibroblast Growth Factor 4*/metabolism , Odontoblasts*/metabolism , Fibroblast Growth Factor 9*/genetics , Fibroblast Growth Factor 9*/metabolism, Animals ; Mice ; Cell Differentiation ; Mice, Transgenic |
| مستخلص: | The purpose of this study was to investigate whether fibroblast growth factor 4 (FGF4) and FGF9 are active in dentin differentiation. Dentin matrix protein 1 (Dmp1) -2A-Cre transgenic mice, which express the Cre-recombinase in Dmp1-expressing cells, were crossed with CAG-tdTomato mice as reporter mouse. The cell proliferation and tdTomato expressions were observed. The mesenchymal cell separated from neonatal molar tooth germ were cultured with or without FGF4, FGF9, and with or without their inhibitors ferulic acid and infigratinib (BGJ398) for 21 days. Their phenotypes were evaluated by cell count, flow cytometry, and real-time PCR. Immunohistochemistry for FGFR1, 2, and 3 expression and the expression of DMP1 were performed. FGF4 treatment of mesenchymal cells obtained promoted the expression of all odontoblast markers. FGF9 failed to enhance dentin sialophosphoprotein (Dspp) expression levels. Runt-related transcription factor 2 (Runx2) was upregulated until day 14 but was downregulated on day 21. Compared to Dmp1-negative cells, Dmp1-positive cells expressed higher levels of all odontoblast markers, except for Runx2. Simultaneous treatment with FGF4 and FGF9 had a synergistic effect on odontoblast differentiation, suggesting that they may play a role in odontoblast maturation. (© 2023. The Author(s) under exclusive licence to The Japanese Society for Clinical Molecular Morphology.) |
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| معلومات مُعتمدة: | 18H03007 Japan Society for the Promotion of Science; 21H03146 Japan Society for the Promotion of Science; 19K19074 Japan Society for the Promotion of Science; Suematsu Gas Biology Exploratory Research for Advanced Technology |
| فهرسة مساهمة: | Keywords: Dmp1; Enamel knot; FGF4; FGF9; Mesenchymal cells; Odontoblast |
| المشرفين على المادة: | 0 (Core Binding Factor Alpha 1 Subunit) 0 (Fibroblast Growth Factor 4) 0 (Fgf4 protein, mouse) 0 (Fgf9 protein, mouse) 0 (Fibroblast Growth Factor 9) |
| تواريخ الأحداث: | Date Created: 20230403 Date Completed: 20231101 Latest Revision: 20231127 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s00795-023-00351-2 |
| PMID: | 37012505 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1860-1499 |
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| DOI: | 10.1007/s00795-023-00351-2 |