دورية أكاديمية
High SARS-CoV-2 seroprevalence among street adolescents in Lomé, Togo, 2021.
| العنوان: | High SARS-CoV-2 seroprevalence among street adolescents in Lomé, Togo, 2021. |
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| المؤلفون: | Sadio AJ; Faculty of Health Sciences, Department of Public Health, University of Lomé, Center for Training and Research in Public Health, Lomé, Togo.; African Center for Research in Epidemiology and Public Health (CARESP), Lomé, Togo.; Research Institute for Sustainable Development (IRD), University of Bordeaux, National Institute for Health and Medical Research (INSERM), Bordeaux Population Health Centre, UMR 1219, Bordeaux, France., Ferré VM; Paris Cité University and Sorbonne Paris Nord University, IAME, Inserm, Paris, F-75018, France.; Virology Unit, AP-HP, Hôpital Bichat-Claude Bernard, Paris, F-75018, France., Konu RY; Faculty of Health Sciences, Department of Public Health, University of Lomé, Center for Training and Research in Public Health, Lomé, Togo.; African Center for Research in Epidemiology and Public Health (CARESP), Lomé, Togo.; Research Institute for Sustainable Development (IRD), University of Bordeaux, National Institute for Health and Medical Research (INSERM), Bordeaux Population Health Centre, UMR 1219, Bordeaux, France., Dagnra AC; Laboratory of Molecular Biology and Immunology, University of Lomé, Lomé, Togo., Descamps D; Paris Cité University and Sorbonne Paris Nord University, IAME, Inserm, Paris, F-75018, France.; Virology Unit, AP-HP, Hôpital Bichat-Claude Bernard, Paris, F-75018, France., Ekouevi DK; Faculty of Health Sciences, Department of Public Health, University of Lomé, Center for Training and Research in Public Health, Lomé, Togo. didier.ekouevi@gmail.fr.; African Center for Research in Epidemiology and Public Health (CARESP), Lomé, Togo. didier.ekouevi@gmail.fr.; Research Institute for Sustainable Development (IRD), University of Bordeaux, National Institute for Health and Medical Research (INSERM), Bordeaux Population Health Centre, UMR 1219, Bordeaux, France. didier.ekouevi@gmail.fr., Charpentier C; Paris Cité University and Sorbonne Paris Nord University, IAME, Inserm, Paris, F-75018, France.; Virology Unit, AP-HP, Hôpital Bichat-Claude Bernard, Paris, F-75018, France. |
| المصدر: | BMC infectious diseases [BMC Infect Dis] 2023 Apr 03; Vol. 23 (1), pp. 200. Date of Electronic Publication: 2023 Apr 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | SARS-CoV-2* , COVID-19*/epidemiology, Humans ; Adolescent ; Female ; Young Adult ; Adult ; Male ; Togo/epidemiology ; Cross-Sectional Studies ; Seroepidemiologic Studies ; Immunoglobulin G ; Antibodies, Viral |
| مستخلص: | Background: There is almost no data on the circulation of SARS-CoV-2 among street adolescents. We conducted a study to document the immunization status of street adolescents in Togo against different variants of SARS-CoV-2. Methods: A cross-sectional study was carried out in 2021 in Lomé, the city with the highest number of COVID 19 cases in Togo (60%). Adolescents aged 13- and 19 years old living on the street were eligible for inclusion. A standardized questionnaire was administered face-to-face to adolescents. A sample of blood was taken and aliquots of plasma were transported to the virology laboratory of the Hôpital Bichat-Claude Bernard (Paris, France). SARS-CoV-2 anti-S and anti-N IgG were measured using chemiluminescent microparticle immunoassay. A quantitative miniaturized and parallel-arranged ELISA assay was used to detect IgG antibodies specifically directed against the different SARS-CoV-2 Variants of Concern (VOC). Results: A total of 299 street adolescents (5.2% female), median age 15 years, interquartile range (14-17 years), were included in this study. The prevalence of SARS-CoV-2 infection was 63.5% (95%CI: 57.8-69.0). Specific-IgG against the ancestral Wuhan strain was developed by 92.0% of subjects. The proportion of patients being immunized against each VOC was 86.8%, 51.1%, 56.3%, 60.0, and 30.5% for the Alpha, Beta, Gamma, Delta, and Omicron VOCs, respectively. Conclusion: This study showed a very high prevalence with approximately 2/3 of Togolese street adolescents having antibodies to SARS-CoV-2 due to a previous infection. These results confirm an under-reporting of COVID-19 cases in Togo, questioning the hypothesis of low virus circulation in Togo and even in Africa. (© 2023. The Author(s).) |
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| فهرسة مساهمة: | Keywords: SARS-CoV-2 seroprevalence; Street adolescents; Togo |
| المشرفين على المادة: | 0 (Immunoglobulin G) 0 (Antibodies, Viral) |
| SCR Organism: | SARS-CoV-2 variants |
| تواريخ الأحداث: | Date Created: 20230404 Date Completed: 20230405 Latest Revision: 20230411 |
| رمز التحديث: | 20230411 |
| مُعرف محوري في PubMed: | PMC10069360 |
| DOI: | 10.1186/s12879-023-08167-2 |
| PMID: | 37013507 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-2334 |
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| DOI: | 10.1186/s12879-023-08167-2 |