دورية أكاديمية
RNAi screen in the Drosophila wing of genes encoding proteins related to cytoskeleton organization and cell division.
| العنوان: | RNAi screen in the Drosophila wing of genes encoding proteins related to cytoskeleton organization and cell division. |
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| المؤلفون: | Ostalé CM; Centro de Biología Molecular 'Severo Ochoa', CSIC and Universidad Autónoma de Madrid, Madrid, 28049, Spain., Vega-Cuesta P; Centro de Biología Molecular 'Severo Ochoa', CSIC and Universidad Autónoma de Madrid, Madrid, 28049, Spain., González T; Centro de Biología Molecular 'Severo Ochoa', CSIC and Universidad Autónoma de Madrid, Madrid, 28049, Spain., López-Varea A; Centro de Biología Molecular 'Severo Ochoa', CSIC and Universidad Autónoma de Madrid, Madrid, 28049, Spain., de Celis JF; Centro de Biología Molecular 'Severo Ochoa', CSIC and Universidad Autónoma de Madrid, Madrid, 28049, Spain. Electronic address: jfdecelis@cbm.csic.es. |
| المصدر: | Developmental biology [Dev Biol] 2023 Jun; Vol. 498, pp. 61-76. Date of Electronic Publication: 2023 Apr 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372762 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-564X (Electronic) Linking ISSN: 00121606 NLM ISO Abbreviation: Dev Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: San Diego, CA : Elsevier Original Publication: New York. |
| مواضيع طبية MeSH: | Drosophila*/metabolism , Drosophila Proteins*/genetics , Drosophila Proteins*/metabolism, Animals ; RNA Interference ; Gene Expression Regulation, Developmental/genetics ; Cell Division/genetics ; Cytoskeleton/genetics ; Cytoskeleton/metabolism ; Wings, Animal ; Drosophila melanogaster/metabolism |
| مستخلص: | Cell division and cytoskeleton organization are fundamental processes participating in the development of Drosophila imaginal discs. In this manuscript we describe the phenotypes in the adult fly wing generated by knockdowns of 85% of Drosophila genes encoding proteins likely related to the regulation of cell division and cytoskeleton organization. We also compile a molecular classification of these proteins into classes that describe their expected or known main biochemical characteristics, as well as mRNA expression in the wing disc and likely protein subcellular localization for a subset of these genes. Finally, we analyze in more detail one protein family of cytoskeleton genes (Arp2/3 complex), and define the consequences of interfering with cell division for wing growth and patterning. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Arp2/3; Cell division; Cytoskeleton; Phenotype; RNAi; Screen; Wing |
| المشرفين على المادة: | 0 (Drosophila Proteins) |
| تواريخ الأحداث: | Date Created: 20230404 Date Completed: 20230509 Latest Revision: 20230515 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ydbio.2023.03.010 |
| PMID: | 37015290 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-564X |
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| DOI: | 10.1016/j.ydbio.2023.03.010 |