دورية أكاديمية
Efficacy of pentasodium diethylenetriamine pentaacetate in ameliorating anosmia post COVID-19.
| العنوان: | Efficacy of pentasodium diethylenetriamine pentaacetate in ameliorating anosmia post COVID-19. |
|---|---|
| المؤلفون: | Imam MS; Pharmacy Practice Department, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia; Clinical Pharmacy Department, National Cancer Institute, Cairo University, Fom El Khalig Square, Kasr Al-Aini Street, Cairo 11796, Egypt., Abdelazim MH; Department of Otolaryngology, Faculty of Medicine, Al-Azhar University, 34518 Damietta, Egypt. Electronic address: mohammedabdelazeem35@yahoo.com., Abdelazim AH; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751 Cairo, Egypt., Ismaiel WF; Department of Otolaryngology, Faculty of Medicine, Al-Azhar University, 34518 Damietta, Egypt., Gamal M; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, 62514 Beni-Suef, Egypt., Abourehab MAS; Department of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Minia University, Minia 61519, Egypt., Alghamdi S; Department of Clinical Pharmacy, Faculty of Clinical Pharmacy, Al Baha University, Al Baha, Saudi Arabia., Alghamdi MA; Department of Surgery, Division of Otolaryngology, Faculty of Medicine, Albaha University, Albaha City, Saudi Arabia., Ghoneim MM; Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi Arabia; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt., Elwany S; Department of Otolaryngology, Faculty of Medicine, Alexandria University, 21500 Alexandria, Egypt. |
| المصدر: | American journal of otolaryngology [Am J Otolaryngol] 2023 Jul-Aug; Vol. 44 (4), pp. 103871. Date of Electronic Publication: 2023 Mar 30. |
| نوع المنشور: | Randomized Controlled Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Saunders Country of Publication: United States NLM ID: 8000029 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-818X (Electronic) Linking ISSN: 01960709 NLM ISO Abbreviation: Am J Otolaryngol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cherry Hill, N. J., Saunders. |
| مواضيع طبية MeSH: | COVID-19*/complications , Olfaction Disorders*/etiology , Olfaction Disorders*/complications, Adult ; Humans ; Anosmia ; SARS-CoV-2 ; Nasal Sprays ; Calcium ; Pentetic Acid/pharmacology ; Smell/physiology |
| مستخلص: | Background: COVID-19 has been frequently demonstrated to be associated with anosmia. Calcium cations are a mainstay in the transmission of odor. One of their documented effects is feedback inhibition. Thus, it has been advocated that reducing the free intranasal calcium cations using topical chelators such as pentasodium diethylenetriamine pentaacetate (DTPA) could lead to restoration of the olfactory function in patients with post-COVID-19 anosmia. Methodology: This is a randomized controlled trial that investigated the effect of DTPA on post-COVID-19 anosmia. A total of 66 adult patients who had confirmed COVID-19 with associated anosmia that continued beyond three months of being negative for SARS-CoV-2 infection. The included patients were randomly allocated to the control group that received 0.9 % sodium chloride-containing nasal spray or the interventional group that received 2 % DTPA-containing nasal spray at a 1:1 ratio. Before treatment and 30 days post-treatment, the patients' olfactory function was evaluated using Sniffin' Sticks, and quantitative estimation of the calcium cations in the nasal mucus was done using a carbon paste ion-selective electrode test. Results: Patients in the DTPA-treated group significantly improved compared to the control group in recovery from functional anosmia to hyposmia. Additionally, they showed a significant post-treatment reduction in the calcium concentration compared to the control group. Conclusion: This study confirmed the efficacy of DTPA in treating post-COVID-19 anosmia. Competing Interests: Declaration of competing interest None declared. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anosmia; Pentasodium diethylenetriamine pentaacetat; Post-COVID-19 |
| المشرفين على المادة: | 03K6SX4V2J (diethylenetriamine) 0 (Nasal Sprays) SY7Q814VUP (Calcium) 7A314HQM0I (Pentetic Acid) |
| تواريخ الأحداث: | Date Created: 20230405 Date Completed: 20230612 Latest Revision: 20230612 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10062716 |
| DOI: | 10.1016/j.amjoto.2023.103871 |
| PMID: | 37018923 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-818X |
|---|---|
| DOI: | 10.1016/j.amjoto.2023.103871 |