دورية أكاديمية
Combined Training Improves Executive Functions Without Changing Brain-Derived Neurotrophic Factor Levels of Middle-Aged and Older Adults with Type 2 Diabetes.
| العنوان: | Combined Training Improves Executive Functions Without Changing Brain-Derived Neurotrophic Factor Levels of Middle-Aged and Older Adults with Type 2 Diabetes. |
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| المؤلفون: | Silveira-Rodrigues JG; Exercise Physiology Laboratory (Lafise), School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte (MG), Brazil., Gardênia de Holanda Marinho Nogueira N; School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte (MG), Brazil., Faria LO; Sport Psychology Laboratory (Lapes), School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte (MG), Brazil., Pereira DS; Department of Physical Therapy, School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte (MG), Brazil., Soares DD; Exercise Physiology Laboratory (Lafise), School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte (MG), Brazil. |
| المصدر: | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association [Exp Clin Endocrinol Diabetes] 2023 Jun; Vol. 131 (6), pp. 345-353. Date of Electronic Publication: 2023 Apr 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: J.A. Barth Country of Publication: Germany NLM ID: 9505926 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-3646 (Electronic) Linking ISSN: 09477349 NLM ISO Abbreviation: Exp Clin Endocrinol Diabetes Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Heidelberg : J.A. Barth, c1995- |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/therapy , Cognitive Dysfunction*, Male ; Middle Aged ; Female ; Humans ; Aged ; Executive Function ; Cognition ; Brain-Derived Neurotrophic Factor |
| مستخلص: | Background: Type 2 diabetes mellitus (T2DM) provokes executive function and long-term memory decrements, and aerobic plus resistance training (combined training) may alleviate this T2DM-related cognitive impairment. Brain-derived neurotrophic factor (BDNF) levels have been found to be related to cognitive performance. Aim: To analyze the effects of 8-week combined training on executive functions and circulating BDNF levels of subjects with T2DM and verify the association between BDNF levels and combined training-induced changes in executive functions and long-term memory. Methods: Thirty-five (63±8 years old) subjects of both sexes were allocated to combined training ( n =17 , thrice weekly for 8 weeks) or the control group ( n =18). Executive functions (evaluated through Trail making test, Stroop color task, and Digit Span), long-term memory (evaluated through the Taylor Complex Figure Test simplified), and plasma samples were compared pre- and post-intervention. Results: Combined training improved executive function z-score compared to control ( d= 1.31). Otherwise, BDNF levels were not statistically altered (combined training group: 179±88 pg/mL vs. 148±108 pg/mL; control group: 163±71 pg/mL vs. 141±84 pg/mL, p >0.05). However, pre-training BDNF levels explained 50.4% of the longitudinal improvements in composite executive function z-score ( r =0.71, p <0.01), 33.6% of inhibitory control ( r= 0.58; p =0.02), and 31.4% of cognitive flexibility ( r= 0.56, p= 0.04) in the combined training group. Conclusion: Combined training improved executive functions independently of alterations in resting BDNF levels after 8 weeks. Furthermore, pre-training BDNF levels explained one-half of the variance in combined training-induced improvements in executive functions. Competing Interests: The authors declare that they have no conflict of interest. (Thieme. All rights reserved.) |
| معلومات مُعتمدة: | 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; APQ 00417-15 ,APQ 0354615 Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
| المشرفين على المادة: | 0 (Brain-Derived Neurotrophic Factor) |
| تواريخ الأحداث: | Date Created: 20230405 Date Completed: 20230616 Latest Revision: 20230616 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1055/a-2069-4050 |
| PMID: | 37019176 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1439-3646 |
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| DOI: | 10.1055/a-2069-4050 |