دورية أكاديمية
Negative energy balance hinders prosocial helping behavior.
| العنوان: | Negative energy balance hinders prosocial helping behavior. |
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| المؤلفون: | Pozo M; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Milà-Guasch M; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Haddad-Tóvolli R; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Boudjadja MB; Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, M13 9PT Manchester, United Kingdom., Chivite I; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Toledo M; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Gómez-Valadés AG; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Eyre E; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Ramírez S; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Obri A; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Ben-Ami Bartal I; School of Psychological Sciences, Tel-Aviv University, 6997801 Tel Aviv, Israel.; Sagol School of Neuroscience, Tel-Aviv University, 6997801 Tel Aviv, Israel., D'Agostino G; Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, M13 9PT Manchester, United Kingdom., Costa-Font J; Department of Health Policy, London School of Economics and Political Science, WC2A 2AE London, United Kingdom., Claret M; Neuronal Control of Metabolism Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Spain.; School of Medicine, Universitat de Barcelona, 08036 Barcelona, Spain. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Apr 11; Vol. 120 (15), pp. e2218142120. Date of Electronic Publication: 2023 Apr 06. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Energy Metabolism* , Helping Behavior*, Animals ; Mice ; Blood Glucose/metabolism ; Adenosine Triphosphate/metabolism ; Adenosine Diphosphate/metabolism ; Prosencephalon/metabolism ; Hunger ; Glycated Hemoglobin/analysis ; Hypothalamus/metabolism ; Glycemic Control ; Mice, Inbred C57BL ; Male ; Humans ; Charities ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Streptozocin |
| مستخلص: | The internal state of an animal, including homeostatic requirements, modulates its behavior. Negative energy balance stimulates hunger, thus promoting a range of actions aimed at obtaining food. While these survival actions are well established, the influence of the energy status on prosocial behavior remains unexplored. We developed a paradigm to assess helping behavior in which a free mouse was faced with a conspecific trapped in a restrainer. We measured the willingness of the free mouse to liberate the confined mouse under diverse metabolic conditions. Around 42% of ad libitum-fed mice exhibited a helping behavior, as evidenced by the reduction in the latencies to release the trapped cagemate. This behavior was independent of subsequent social contact reward and was associated with changes in corticosterone indicative of emotional contagion. This decision-making process was coupled with reduced blood glucose excursions and higher Adenosine triphosphate (ATP):Adenosine diphosphate (ADP) ratios in the forebrain of helper mice, suggesting that it was a highly energy-demanding process. Interestingly, chronic (food restriction and type 2 diabetes) and acute (chemogenetic activation of hunger-promoting AgRP neurons) situations mimicking organismal negative energy balance and enhanced appetite attenuated helping behavior toward a distressed conspecific. To investigate similar effects in humans, we estimated the influence of glycated hemoglobin (a surrogate of long-term glycemic control) on prosocial behavior (namely charity donation) using the Understanding Society dataset. Our results evidenced that organismal energy status markedly influences helping behavior and that hypothalamic AgRP neurons are at the interface of metabolism and prosocial behavior. |
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| معلومات مُعتمدة: | 725004 EC | Horizon 2020 Framework Programme (H2020); BFU2015-72486-EXP Ministerio de Ciencia, Innovación y Universidades (MCIU) |
| فهرسة مساهمة: | Keywords: AgRP neurons; energy status; helping behavior; hunger; hypothalamus |
| سلسلة جزيئية: | figshare 10.6084/m9.figshare.22276525 |
| المشرفين على المادة: | 0 (Blood Glucose) 8L70Q75FXE (Adenosine Triphosphate) 61D2G4IYVH (Adenosine Diphosphate) 0 (Glycated Hemoglobin) 5W494URQ81 (Streptozocin) |
| تواريخ الأحداث: | Date Created: 20230406 Date Completed: 20230410 Latest Revision: 20240314 |
| رمز التحديث: | 20240314 |
| مُعرف محوري في PubMed: | PMC10104524 |
| DOI: | 10.1073/pnas.2218142120 |
| PMID: | 37023123 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
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| DOI: | 10.1073/pnas.2218142120 |