دورية أكاديمية
أعرض في EDS

Influence of IL-6 rs1800795 and IL-8 rs2227306 polymorphisms on COVID-19 outcome.

التفاصيل البيبلوغرافية
العنوان: Influence of IL-6 rs1800795 and IL-8 rs2227306 polymorphisms on COVID-19 outcome.
المؤلفون: Ghazy AA; Department of Pathology, Microbiology and Immunology Division, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
المصدر: Journal of infection in developing countries [J Infect Dev Ctries] 2023 Mar 31; Vol. 17 (3), pp. 327-334. Date of Electronic Publication: 2023 Mar 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Open Learning on Enteric Pathogens Country of Publication: Italy NLM ID: 101305410 Publication Model: Electronic Cited Medium: Internet ISSN: 1972-2680 (Electronic) Linking ISSN: 19722680 NLM ISO Abbreviation: J Infect Dev Ctries Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Italy?] : Open Learning on Enteric Pathogens
مواضيع طبية MeSH: Interleukin-6*/genetics , COVID-19*/genetics, Humans ; Male ; Young Adult ; Adult ; Middle Aged ; Aged ; Interleukin-8/genetics ; Genetic Predisposition to Disease ; SARS-CoV-2/genetics ; Genotype ; Polymorphism, Single Nucleotide ; Alleles ; Case-Control Studies
مستخلص: Introduction: Severe coronavirus disease 2019 (COVID-19) is mainly precipitated by an uncontrolled inflammatory response and cytokine storm. Pro-inflammatory cytokines such as IL-6 and IL-8 levels were markedly increased in complicated cases. Genetic polymorphisms may have a role in this dysregulated expression during SARS-CoV-2 infection. Our aim was to assess the influence of IL-6 and IL-8 single nucleotide polymorphisms (SNPs) on COVID-19 outcomes.
Methodology: 240 subjects were involved in the study; 80 cases with severe COVID-19, 80 cases with mild COVID-19, and 80 healthy subjects. IL-6rs1800795(G/C) and IL-8 rs2227306(C/T) genotyping was performed using real-time polymerase chain reaction (PCR).
Results: Ages ranged between 20-67 years in all groups. There was a statistically significant association between the male gender and severe COVID-19. A significantly higher expression of IL-6rs1800795GG and IL-8rs2227306CC genotypes was observed among patients with severe COVID-19 than other groups. At the allele level, IL-6rs1800795G and IL-8rs2227306C alleles were more frequent among patients with severe COVID-19 when compared with other groups. Haplotypes' frequency clarified that the coexistence of IL-6 rs1800795G and IL-8rs2227306C alleles in the same person increased the risk of severe COVID-19 outcomes. Carriers of IL-6rs1800795C and IL-8 rs2227306T alleles are at lower risk of developing severe COVID-19. Multivariate logistic regression analysis showed that old age, male gender, IL-6 rs1800795CG+GG, and IL-8 rs2227306CT+CC genotypes could be independent risk factors for severe COVID-19 outcomes.
Conclusions: IL-6 rs1800795G and IL-8 rs2227306C alleles are significantly associated with severe COVID-19 outcomes, especially if they coexist. They may be used as prognostic markers for COVID-19.
Competing Interests: No Conflict of Interest is declared
(Copyright (c) 2023 Amany A Ghazy.)
فهرسة مساهمة: Keywords: COVID-19; IL-6 rs1800795; IL-8 rs2227306; SNP; outcome
المشرفين على المادة: 0 (Interleukin-6)
0 (Interleukin-8)
تواريخ الأحداث: Date Created: 20230406 Date Completed: 20230410 Latest Revision: 20230615
رمز التحديث: 20240628
DOI: 10.3855/jidc.17717
PMID: 37023437
قاعدة البيانات: MEDLINE
الوصف
تدمد:1972-2680
DOI:10.3855/jidc.17717