دورية أكاديمية
Phytochemical profile, comparative evaluation of Satureja montana alcoholic extract for antioxidants, anti-inflammatory and molecular docking studies.
| العنوان: | Phytochemical profile, comparative evaluation of Satureja montana alcoholic extract for antioxidants, anti-inflammatory and molecular docking studies. |
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| المؤلفون: | Abdelshafeek KA; Chemistry of Medicinal Plants Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Buhouth St. (Former El Tahrir St.), 12622-Dokki, Giza, Egypt., Osman AF; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Buhouth St. (Former El Tahrir St.), 12622-Dokki, Giza, Egypt., Mouneir SM; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Cairo, 12211, Egypt., Elhenawy AA; Chemistry Department, Faculty of Science, Al-Azhar University, 11884 Nasr City, Cairo, Egypt., Abdallah WE; Chemistry of Medicinal Plants Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Buhouth St. (Former El Tahrir St.), 12622-Dokki, Giza, Egypt. we.el-sayed@nrc.sci.eg. |
| المصدر: | BMC complementary medicine and therapies [BMC Complement Med Ther] 2023 Apr 06; Vol. 23 (1), pp. 108. Date of Electronic Publication: 2023 Apr 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101761232 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-7671 (Electronic) Linking ISSN: 26627671 NLM ISO Abbreviation: BMC Complement Med Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2020]- |
| مواضيع طبية MeSH: | Antioxidants*/chemistry , Satureja*/chemistry, Molecular Docking Simulation ; Plant Extracts/chemistry ; Montana ; Phytochemicals/pharmacology ; Anti-Inflammatory Agents/pharmacology |
| مستخلص: | Background: The most common species in the Satureja genus is Satureja montana (family Lamiaceae). The present work aims to use the molecular docking study to predict the isolated constituents against an immune system immunomodulator and tested alcoholic extract as an in-vitro immunomodulatory agent. Methods: All isolated compound's structures were determined using various chromatographic and spectroscopic techniques. Anti-inflammatory and antioxidant profiles were studied for an alcoholic extract of the plant; the molecular docking study was performed for the isolated compounds (1-4). Results: In this work, four recognized compounds were extracted from the ethyl acetate fraction of S. montana (Sm) methanolic extract and identified as two triterpenes ursolic acid (1) and oleanolic acid (2), one phenolic acid as ellagic acid (3), and one flavonoidal compound as isoscutellarein (4). The total alcoholic extract exhibited good in vitro anti-inflammatory, antioxidant, and apoptotic activity. Its IC Conclusions: The alcoholic extract of the plant showed promising anti-inflammatory, antioxidant, and antiapoptotic properties. The theoretical studies for the isolated compounds showed promising binding affinity against all the examined enzymes. (© 2023. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Anti-inflammatory activity; Flavonoids; Lamiaceae; Molecular docking; Satureja montana; Ursolic acid |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Plant Extracts) 3WAC3UX5SC (isoscutellarein) 0 (Phytochemicals) 0 (Anti-Inflammatory Agents) |
| تواريخ الأحداث: | Date Created: 20230406 Date Completed: 20230410 Latest Revision: 20230411 |
| رمز التحديث: | 20230411 |
| مُعرف محوري في PubMed: | PMC10077692 |
| DOI: | 10.1186/s12906-023-03913-0 |
| PMID: | 37024878 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2662-7671 |
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| DOI: | 10.1186/s12906-023-03913-0 |