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Case report: Radiographic complete response of radiation-induced glioblastoma to front-line radiotherapy: A report and molecular characterization of two unique cases.

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العنوان: Case report: Radiographic complete response of radiation-induced glioblastoma to front-line radiotherapy: A report and molecular characterization of two unique cases.
المؤلفون: Grogan PT; Department of Medicine, Division of Hematology, Medical Oncology, and Palliative Care, University of Wisconsin, Madison, WI, United States.; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin, Madison, WI, United States.; Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI, United States., Helgager JJ; Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, United States., Deming DA; Department of Medicine, Division of Hematology, Medical Oncology, and Palliative Care, University of Wisconsin, Madison, WI, United States.; McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin, Madison, WI, United States.; Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI, United States., Howard SP; Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI, United States.; Department of Human Oncology, University of Wisconsin, Madison, WI, United States., Jenkins RB; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States., Robins HI; Department of Medicine, Division of Hematology, Medical Oncology, and Palliative Care, University of Wisconsin, Madison, WI, United States.; Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI, United States.; Department of Human Oncology, University of Wisconsin, Madison, WI, United States.; Department of Neurology, University of Wisconsin, Madison, WI, United States.
المصدر: Frontiers in neurology [Front Neurol] 2023 Mar 21; Vol. 14, pp. 1099424. Date of Electronic Publication: 2023 Mar 21 (Print Publication: 2023).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2295 (Print) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation, 2010]-
مستخلص: Radiation-induced gliomas (RIGs) are an uncommon disease type and a known long-term complication of prior central nervous system radiation exposure, often during childhood. Given the rarity of this malignancy subtype, no clinical trials have explored optimal therapy for these patients, and the literature is primarily limited to reports of patient cases and series. Indeed, the genomic profiles of RIGs have only recently been explored in limited numbers, categorizing these gliomas into a unique subset. Here, we describe two cases of RIG diagnosed as glioblastoma (GB), IDH-wildtype, in adults who had previously received central nervous system radiation for childhood cancers. Both patients demonstrated a surprising complete radiographic response of the postoperative residual disease to front-line therapy, a phenomenon rarely observed in the management of any GB and never previously reported for the radiation-induced subgroup. Both tumors were characterized by next-generation sequencing and chromosomal microarray to identify potential etiologies for this response as well as to further add to the limited literature about the unique molecular profile of RIGs, showing signatures more consistent with diffuse pediatric-type high-grade glioma, H3 -wildtype, and IDH-wildtype, WHO grade 4. Ultimately, we demonstrate that treatment utilizing a radiation-based regimen for GB in a previously radiated tissue can be highly successful despite historical limitations in the management of this disease.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Grogan, Helgager, Deming, Howard, Jenkins and Robins.)
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معلومات مُعتمدة: T32 CA009135 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: chromosomal microarray; complete response (CR); molecular sequencing; radiation; radiation-induced glioma (RIG)
تواريخ الأحداث: Date Created: 20230407 Latest Revision: 20240123
رمز التحديث: 20240123
مُعرف محوري في PubMed: PMC10070702
DOI: 10.3389/fneur.2023.1099424
PMID: 37025206
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2295
DOI:10.3389/fneur.2023.1099424