دورية أكاديمية
Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup.
| العنوان: | Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup. |
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| المؤلفون: | Weckel A; University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA., Dhariwala MO; University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA., Ly K; University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA; University of California, San Francisco, Biomedical Sciences Graduate Program, San Francisco, CA 94143, USA., Tran VM; University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA; University of California, San Francisco, Biomedical Sciences Graduate Program, San Francisco, CA 94143, USA., Ojewumi OT; University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA., Riggs JB; University of California, San Francisco, Biomedical Sciences Graduate Program, San Francisco, CA 94143, USA., Gonzalez JR; University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA; University of California, San Francisco, Biomedical Sciences Graduate Program, San Francisco, CA 94143, USA., Dwyer LR; University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA; University of California, San Francisco, Biomedical Sciences Graduate Program, San Francisco, CA 94143, USA., Okoro JN; University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA., Leech JM; University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA., Bacino MS; University of California, San Francisco, Oral and Craniofacial Sciences Graduate Program, San Francisco, CA 94143, USA., Cho GD; University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA; University of California, Los Angeles, Department of Infectious Diseases, Los Angeles, CA 90095, USA., Merana G; University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA., Anandasabapathy N; Department of Dermatology, Meyer Cancer Center, Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Medical College, New York, NY, USA., Kumamoto Y; Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA; Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, USA., Scharschmidt TC; University of California, San Francisco, Department of Dermatology, San Francisco, CA 94143, USA. Electronic address: tiffany.scharschmidt@ucsf.edu. |
| المصدر: | Immunity [Immunity] 2023 Jun 13; Vol. 56 (6), pp. 1239-1254.e7. Date of Electronic Publication: 2023 Apr 06. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge, MA : Cell Press Original Publication: Cambridge, Mass. : Cell Press, c1994- |
| مواضيع طبية MeSH: | Skin* , Dendritic Cells*, Animals ; Mice ; Humans ; T-Lymphocytes, Regulatory ; Immune Tolerance ; Aldehyde Oxidoreductases/metabolism |
| مستخلص: | Early-life establishment of tolerance to commensal bacteria at barrier surfaces carries enduring implications for immune health but remains poorly understood. Here, we showed that tolerance in skin was controlled by microbial interaction with a specialized subset of antigen-presenting cells. More particularly, CD301b + type 2 conventional dendritic cells (DCs) in neonatal skin were specifically capable of uptake and presentation of commensal antigens for the generation of regulatory T (Treg) cells. CD301b + DC2 were enriched for phagocytosis and maturation programs, while also expressing tolerogenic markers. In both human and murine skin, these signatures were reinforced by microbial uptake. In contrast to their adult counterparts or other early-life DC subsets, neonatal CD301b + DC2 highly expressed the retinoic-acid-producing enzyme, RALDH2, the deletion of which limited commensal-specific Treg cell generation. Thus, synergistic interactions between bacteria and a specialized DC subset critically support early-life tolerance at the cutaneous interface. Competing Interests: Declaration of interests T.C.S. is on the Scientific Advisory Board of Concerto Biosciences. N.A. is on the Scientific Advisory Board for Shennon Biotech, and consults or lectures for 23andMe, Cellino Biotech, Janssen Pharmaceuticals, and Immunitas Therapeutics. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | P30 DK063720 United States DK NIDDK NIH HHS; R01 AR080034 United States AR NIAMS NIH HHS; R01 AR080436 United States AR NIAMS NIH HHS; DP2 AI144968 United States AI NIAID NIH HHS; S10 OD021822 United States OD NIH HHS; K99 AR079554 United States AR NIAMS NIH HHS |
| فهرسة مساهمة: | Keywords: Staphylococcus epidermidis; commensal bacteria; commensals; dendritic cells; early-life immunity; neonatal immunity; regulatory T cells; retinoic acid; skin; tolerance |
| المشرفين على المادة: | EC 1.2.1.36 (RALDH2 protein, mouse) EC 1.2.- (Aldehyde Oxidoreductases) |
| تواريخ الأحداث: | Date Created: 20230407 Date Completed: 20230616 Latest Revision: 20240614 |
| رمز التحديث: | 20240614 |
| مُعرف محوري في PubMed: | PMC10330031 |
| DOI: | 10.1016/j.immuni.2023.03.008 |
| PMID: | 37028427 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1097-4180 |
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| DOI: | 10.1016/j.immuni.2023.03.008 |