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Tetraacetyl riboflavin derivative mediates caspase 3/7 activation via MAPK in A431 cells upon blue light influence.

التفاصيل البيبلوغرافية
العنوان: Tetraacetyl riboflavin derivative mediates caspase 3/7 activation via MAPK in A431 cells upon blue light influence.
المؤلفون: Buniowska I; Department of Biophysics and Cancer Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland., Wronski N; Department of Biophysics and Cancer Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland., Insinska-Rak M; Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland., Sikorski M; Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland., Wolnicka-Glubisz A; Department of Biophysics and Cancer Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
المصدر: Photochemistry and photobiology [Photochem Photobiol] 2024 Jan-Feb; Vol. 100 (1), pp. 204-213. Date of Electronic Publication: 2023 May 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Society for Photobiology Country of Publication: United States NLM ID: 0376425 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1751-1097 (Electronic) Linking ISSN: 00318655 NLM ISO Abbreviation: Photochem Photobiol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2004->: Lawrence KS : American Society for Photobiology
Original Publication: Augusta, GA: American Society for Photobiology, <1996->
مواضيع طبية MeSH: Blue Light* , Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology, Caspase 3/metabolism ; Caspase 3/pharmacology ; p38 Mitogen-Activated Protein Kinases/metabolism ; Apoptosis ; Phosphorylation ; Riboflavin/pharmacology ; Riboflavin/metabolism
مستخلص: An acetylated riboflavin derivative, 3-methyl-tetraacetyl riboflavin (3MeTARF), is a compound with high photostability and photophysical properties similar to riboflavin, including the ability to photogenerate singlet oxygen. In the present study, we compared the effects of irradiation on A431 cancer cells with blue LED light (438 nm) in the presence of 3MeTARF and riboflavin on MAPK phosphorylation, apoptosis, caspase 3/7 activation and PARP cleavage. We observed that photogenerated oxidative stress in this reaction activates MAPK by increasing phosphorylation of p38 and JNK proteins. Preincubation of cells with inhibitors specific for phosphorylation of p38 and JNK proteins (SB203580, SP600125), respectively, results in decreased caspase 3/7 activation and PARP cleavage. We showed that the tetraacetyl derivative more effectively activates MAPK and skin cancer cell death compared to riboflavin. These data, together with results of our previous study, support the hypothesis that 3MeTARF, of riboflavin, might be more useful and desirable as a compound for use in photodynamic oxidation processes, including its therapeutic potential.
(© 2023 American Society for Photobiology.)
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معلومات مُعتمدة: 2012/05/B/NZ1/00004 Narodowe Centrum Nauki; 2017/27/B/ST4/02494 Narodowe Centrum Nauki
فهرسة مساهمة: Keywords: 3MeTRAF; MAPK; apoptosis; blue light; caspase; riboflavin; skin cancer
المشرفين على المادة: EC 3.4.22.- (Caspase 3)
0 (Poly(ADP-ribose) Polymerase Inhibitors)
EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
TLM2976OFR (Riboflavin)
تواريخ الأحداث: Date Created: 20230408 Date Completed: 20240117 Latest Revision: 20240117
رمز التحديث: 20240117
DOI: 10.1111/php.13806
PMID: 37029736
قاعدة البيانات: MEDLINE
الوصف
تدمد:1751-1097
DOI:10.1111/php.13806