دورية أكاديمية
أعرض في EDS

Protective effects of Theracurmin treatment during experimental infection of the Colombian strain of Trypanosoma cruzi at the testicular site.

التفاصيل البيبلوغرافية
العنوان: Protective effects of Theracurmin treatment during experimental infection of the Colombian strain of Trypanosoma cruzi at the testicular site.
المؤلفون: Pimenta BL; Laboratory of Immunobiology of Inflammation, Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.; Infectious Diseases and Tropical Medicine Post-Graduate Program, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Menezes TP; Laboratory of Immunobiology of Inflammation, Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.; Health and Nutrition Post-Graduate Program, School of Nutrition, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Louise V; Laboratory of Immunobiology of Inflammation, Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.; Infectious Diseases and Tropical Medicine Post-Graduate Program, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Health and Nutrition Post-Graduate Program, School of Nutrition, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Dias FCR; Department of Veterinary, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil., Machado BAA; Laboratory of Immunobiology of Inflammation, Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.; School of Medicine, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Ribeiro L; Laboratory of Immunobiology of Inflammation, Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.; Infectious Diseases and Tropical Medicine Post-Graduate Program, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Pinto KMC; Laboratory of Immunobiology of Inflammation, Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.; Laboratory of Physiology of Exercise, School of Physical Education, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Talvani A; Laboratory of Immunobiology of Inflammation, Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.; Infectious Diseases and Tropical Medicine Post-Graduate Program, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Health and Nutrition Post-Graduate Program, School of Nutrition, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
المصدر: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Mar 24; Vol. 13, pp. 1143360. Date of Electronic Publication: 2023 Mar 24 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media SA
مواضيع طبية MeSH: Trypanosoma cruzi* , Chagas Disease*/parasitology, Male ; Mice ; Animals ; Testis/pathology ; Colombia ; Macrophages/metabolism
مستخلص: Introduction: Chagas' disease is a tropical neglected illness caused by Trypanosoma cruzi and remains one of the most significant causes of morbidity and mortality in South and Central Americas. The disease is caused by a moderate to intense and persistent inflammatory response characterized by local upregulated expression and production of inflammatory mediators that favors the activation and recruitment of distinct cells of the immune system into different tissues to eliminate the parasites. Theracurmin is a curcumin's derived formulation of nanoparticles. Its anti-inflammatory properties make this bioactive compound a mitigating factor in pathological cases after an overwhelming inflammatory response.
Methods: Our research focused on the testicular investigation in 28 mice infected by 103 trypomastigote forms of Colombian strain of T. cruzi and preventively treated with Theracurmin. The mice were treated with 30 mg/Kg of Theracurmin during the period of 30 days. At the 30th day post infection animals were euthanized, and its testicles were collected to morphological and immunological assays.
Results: The animals infected and treated with Theracurmin presented a reduction in the testicular levels of IL-15 and IL-6. The volume density (%) of the tunica propria was also higher in all infected animals, but Theracurmin decreased this parameter in the treated animals. In the intertubular area, the percentage of some intertubular components was decreased in the infected animals such as the percentage and volume of Leydig cells, connective tissue, and macrophages.
Discussion: Furthermore, our data pointed to the daily use of Theracurmin in the diet as a protective element of the testicular function.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2023 Pimenta, Menezes, Louise, Dias, Machado, Ribeiro, Pinto and Talvani.)
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فهرسة مساهمة: Keywords: Colombian strain; Trypanosoma cruzi; cytokines; inflammation; testicles; theracurmin
تواريخ الأحداث: Date Created: 20230410 Date Completed: 20230411 Latest Revision: 20230414
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10079985
DOI: 10.3389/fcimb.2023.1143360
PMID: 37033490
قاعدة البيانات: MEDLINE
الوصف
تدمد:2235-2988
DOI:10.3389/fcimb.2023.1143360