دورية أكاديمية
Increased GS-II lectin binding and SATB2 downregulation are biological features for sessile serrated lesions and microvesicular hyperplastic polyps.
| العنوان: | Increased GS-II lectin binding and SATB2 downregulation are biological features for sessile serrated lesions and microvesicular hyperplastic polyps. |
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| المؤلفون: | Matoba H; Department of Molecular Pathology, Shinshu University School of Medicine, Matsumoto, Japan., Iwaya M; Department of Laboratory Medicine and Pathology, Shinshu University Hospital, Matsumoto, Japan., Sato Y; Department of Molecular Pathology, Shinshu University School of Medicine, Matsumoto, Japan., Kobayashi N; Department of Laboratory Medicine, JA North Alps Medical Center Azumi Hospital, Oaza-ikeda, Kitaazumi-gun, Japan., Takemura H; Department of Laboratory Medicine, JA North Alps Medical Center Azumi Hospital, Oaza-ikeda, Kitaazumi-gun, Japan., Kouno Y; Department of Pathology, Ina Central Hospital, Koshiroukubo, Ina, Japan., Karasawa A; Department of Pathology, Ina Central Hospital, Koshiroukubo, Ina, Japan., Nakayama J; Department of Molecular Pathology, Shinshu University School of Medicine, Matsumoto, Japan. |
| المصدر: | Pathology international [Pathol Int] 2023 Jun; Vol. 73 (6), pp. 246-254. Date of Electronic Publication: 2023 Apr 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published by Blackwell Scientific Publications for the Japanese Society of Pathology Country of Publication: Australia NLM ID: 9431380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1827 (Electronic) Linking ISSN: 13205463 NLM ISO Abbreviation: Pathol Int Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Carlton South, Vic., Australia : Published by Blackwell Scientific Publications for the Japanese Society of Pathology, c1994- |
| مواضيع طبية MeSH: | Colonic Polyps*/pathology , Adenoma*/pathology , Colorectal Neoplasms*/pathology , Matrix Attachment Region Binding Proteins*/metabolism, Humans ; Griffonia/metabolism ; Down-Regulation ; Goblet Cells/pathology ; Transcription Factors/metabolism |
| مستخلص: | Sessile serrated lesions (SSLs) and microvesicular hyperplastic polyps (MVHPs) are colorectal lesions displaying gastric differentiation. Griffonia simplicifolia-II (GS-II) is a lectin specific to terminal α/βGlcNAc residues. Here, we assessed GS-II binding and performed immunostaining for HIK1083 (specific to terminal αGlcNAc residues), MUC5AC, MUC6, and special AT-rich sequence binding protein 2 (SATB2) in SSLs, MVHPs, and tubular adenomas (TAs). We observed MUC5AC positivity in 28 of 30 SSLs, but in only three of 23 TAs. Moreover, 24 of 30 SSLs were MUC6-positive, while none of the 23 TAs were MUC6-positive. None of the 30 SSLs or 23 TAs showed HIK1083 positivity. All 30 SSLs and 26 MVHPs were GS-II-positive, while only seven of 23 were in TAs. GS-II staining was mainly distributed in the Golgi region, but SSLs and MVHPs showed goblet cell distribution, in 20 of 30 and 19 of 26 cases, respectively. All SSLs, MVHPs, and TAs were SATB2-positive, but 21 of 30 SSLs and 12 of 26 MVHPs showed decreased staining intensity relative to adjacent mucosa, a decrease seen in only two of 23 in TAs. These results indicate overall that increased terminal βGlcNAc and decreased SATB2 expression are characteristics of SSLs and MVHPs. (© 2023 The Authors. Pathology International published by Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.) |
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| معلومات مُعتمدة: | 19H03441 Japan Society for the Promotion of Science; 21K15400 Japan Society for the Promotion of Science |
| فهرسة مساهمة: | Keywords: GS-II; SATB2; microvesicular hyperplastic polyps; sessile serrated lesions; βGlcNAc |
| المشرفين على المادة: | 0 (SATB2 protein, human) 0 (Transcription Factors) 0 (Matrix Attachment Region Binding Proteins) |
| تواريخ الأحداث: | Date Created: 20230410 Date Completed: 20230622 Latest Revision: 20230622 |
| رمز التحديث: | 20230622 |
| DOI: | 10.1111/pin.13321 |
| PMID: | 37036163 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1440-1827 |
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| DOI: | 10.1111/pin.13321 |