دورية أكاديمية
IL-27 attenuates IL-23 mediated inflammatory arthritis.
| العنوان: | IL-27 attenuates IL-23 mediated inflammatory arthritis. |
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| المؤلفون: | Sarin R; Department of Internal Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis Medical Center, Sacramento, CA, USA., Gu R; Department of Internal Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis Medical Center, Sacramento, CA, USA., Jalali Z; Department of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Maverakis E; Department of Dermatology, University of California at Davis Medical Center, Sacramento, CA, USA., Tsokos MG; Department of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Adamopoulos IE; Department of Internal Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis Medical Center, Sacramento, CA, USA; Department of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: Iadamopo@bidmc.harvard.edu. |
| المصدر: | Clinical immunology (Orlando, Fla.) [Clin Immunol] 2023 Jun; Vol. 251, pp. 109327. Date of Electronic Publication: 2023 Apr 08. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Orlando, FL : Academic Press, c1999- |
| مواضيع طبية MeSH: | Interleukin-27* , Arthritis, Experimental*, Animals ; Cytokines ; Inflammation ; Interleukin-23 ; Th17 Cells |
| مستخلص: | Interleukin 27 has both pro-inflammatory and anti-inflammatory properties in autoimmunity. The anti-inflammatory effects of IL-27 are linked with inhibition of Th17 differentiation but the IL-27 effect on myeloid cells is less studied. Herein we demonstrate that IL-27 inhibits IL-23-induced inflammation associated not only with Th17 cells but also with myeloid cell infiltration in the joints and splenic myeloid populations of CD11b + GR1 + and CD3 - CD11b + CD11c - GR1 - cells. The IL-27 anti-inflammatory response was associated with reduced levels of myeloid cells in the spleen and bone marrow. Overall, our data demonstrate that IL-27 has an immunosuppressive role that affects IL-23-dependent myelopoiesis in the bone marrow and its progression to inflammatory arthritis and plays a crucial role in controlling IL-23 driven joint inflammation by negatively regulating the expansion of myeloid cell subsets. Competing Interests: Declaration of Competing Interest The authors have no financial conflicts of interest. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
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| معلومات مُعتمدة: | R01 AR062173 United States AR NIAMS NIH HHS |
| فهرسة مساهمة: | Keywords: Inflammatory arthritis; Interleukin 23; Interleukin 27; Osteoclasts |
| المشرفين على المادة: | 0 (Interleukin-27) 0 (Cytokines) 0 (Interleukin-23) |
| تواريخ الأحداث: | Date Created: 20230410 Date Completed: 20230523 Latest Revision: 20240603 |
| رمز التحديث: | 20240603 |
| مُعرف محوري في PubMed: | PMC10205692 |
| DOI: | 10.1016/j.clim.2023.109327 |
| PMID: | 37037268 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1521-7035 |
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| DOI: | 10.1016/j.clim.2023.109327 |