دورية أكاديمية
أعرض في EDS

Dopamine differentially modulates medial temporal lobe activity and behavior during spatial navigation in young and older adults.

التفاصيل البيبلوغرافية
العنوان: Dopamine differentially modulates medial temporal lobe activity and behavior during spatial navigation in young and older adults.
المؤلفون: Baeuchl C; Faculty of Psychology, Technische Universität Dresden, Dresden, Germany. Electronic address: christian.baeuchl@tu-dresden.de., Glöckner F; Faculty of Psychology, Technische Universität Dresden, Dresden, Germany., Koch C; Max Planck Research Group NeuroCode, Max Planck Institute for Human Development, Berlin, Germany; International Max Planck Research School on the Life Course (LIFE), Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Aging Research, Berlin, Germany., Petzold J; Department of Psychiatry, Technische Universität Dresden, Dresden, Germany., Schuck NW; Max Planck Research Group NeuroCode, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Aging Research, Berlin, Germany; Institute of Psychology, Universität Hamburg, Hamburg, German., Smolka MN; Department of Psychiatry, Technische Universität Dresden, Dresden, Germany., Li SC; Faculty of Psychology, Technische Universität Dresden, Dresden, Germany; Centre for Tactile Internet with Human-in-the-Loop, Technische Universität Dresden, Dresden, Germany.
المصدر: NeuroImage [Neuroimage] 2023 Jun; Vol. 273, pp. 120099. Date of Electronic Publication: 2023 Apr 08.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Orlando, FL : Academic Press, c1992-
مواضيع طبية MeSH: Dopamine* , Spatial Navigation*/physiology, Aged ; Humans ; Young Adult ; Hippocampus/physiology ; Levodopa/pharmacology ; Spatial Memory/physiology ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/physiology ; Double-Blind Method
مستخلص: Aging is associated with changes in spatial navigation behavior. In addition to an overall performance decline, older adults tend to rely more on proximal location cue information than on environmental boundary information during spatial navigation compared to young adults. The fact that older adults are more susceptible to errors during spatial navigation might be partly attributed to deficient dopaminergic modulation of hippocampal and striatal functioning. Hence, elevating dopamine levels might differentially modulate spatial navigation and memory performance in young and older adults. In this work, we administered levodopa (L-DOPA) in a double-blind within-subject, placebo-controlled design and recorded functional neuroimaging while young and older adults performed a 3D spatial navigation task in which boundary geometry or the position of a location cue were systematically manipulated. An age by intervention interaction on the neural level revealed an upregulation of brain responses in older adults and a downregulation of responses in young adults within the medial temporal lobe (including hippocampus and parahippocampus) and brainstem, during memory retrieval. Behaviorally, L-DOPA had no effect on older adults' overall memory performance; however, older adults whose spatial memory improved under L-DOPA also showed a shift towards more boundary processing under L-DOPA. In young adults, L-DOPA induced a decline in spatial memory performance in task-naïve participants. These results are consistent with the inverted-U-shaped hypothesis of dopamine signaling and cognitive function and suggest that increasing dopamine availability improves hippocampus-dependent place learning in some older adults.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.
(Copyright © 2023. Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: Aging; Dopamine; Hippocampus; Memory; Spatial navigation; fMRI
المشرفين على المادة: VTD58H1Z2X (Dopamine)
46627O600J (Levodopa)
تواريخ الأحداث: Date Created: 20230410 Date Completed: 20230512 Latest Revision: 20230512
رمز التحديث: 20230512
DOI: 10.1016/j.neuroimage.2023.120099
PMID: 37037380
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9572
DOI:10.1016/j.neuroimage.2023.120099