دورية أكاديمية
Three undescribed coumarins from the roots of Angelica pubescens .
| العنوان: | Three undescribed coumarins from the roots of Angelica pubescens . |
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| المؤلفون: | Ni F; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.; Jiangsu Kanion Parmaceutical Co., Ltd, Lianyungang, Jiangsu, China.; The National & Local Joint Engineering Research Center on the Intelligent manufacturing of TCM, Lianyungang, Jiangsu, China., Xie X; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.; Jiangsu Kanion Parmaceutical Co., Ltd, Lianyungang, Jiangsu, China.; The National & Local Joint Engineering Research Center on the Intelligent manufacturing of TCM, Lianyungang, Jiangsu, China.; College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning, China., Huai X; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.; Jiangsu Kanion Parmaceutical Co., Ltd, Lianyungang, Jiangsu, China.; The National & Local Joint Engineering Research Center on the Intelligent manufacturing of TCM, Lianyungang, Jiangsu, China., Yu X; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.; Jiangsu Kanion Parmaceutical Co., Ltd, Lianyungang, Jiangsu, China.; The National & Local Joint Engineering Research Center on the Intelligent manufacturing of TCM, Lianyungang, Jiangsu, China., Zhang H; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.; Jiangsu Kanion Parmaceutical Co., Ltd, Lianyungang, Jiangsu, China.; The National & Local Joint Engineering Research Center on the Intelligent manufacturing of TCM, Lianyungang, Jiangsu, China., Li M; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.; Jiangsu Kanion Parmaceutical Co., Ltd, Lianyungang, Jiangsu, China.; The National & Local Joint Engineering Research Center on the Intelligent manufacturing of TCM, Lianyungang, Jiangsu, China., Wen J; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.; Jiangsu Kanion Parmaceutical Co., Ltd, Lianyungang, Jiangsu, China.; The National & Local Joint Engineering Research Center on the Intelligent manufacturing of TCM, Lianyungang, Jiangsu, China., Yan M; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.; Jiangsu Kanion Parmaceutical Co., Ltd, Lianyungang, Jiangsu, China.; The National & Local Joint Engineering Research Center on the Intelligent manufacturing of TCM, Lianyungang, Jiangsu, China., Zhang C; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.; Jiangsu Kanion Parmaceutical Co., Ltd, Lianyungang, Jiangsu, China.; The National & Local Joint Engineering Research Center on the Intelligent manufacturing of TCM, Lianyungang, Jiangsu, China., Wang Z; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.; Jiangsu Kanion Parmaceutical Co., Ltd, Lianyungang, Jiangsu, China.; The National & Local Joint Engineering Research Center on the Intelligent manufacturing of TCM, Lianyungang, Jiangsu, China., Xiao W; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China.; Jiangsu Kanion Parmaceutical Co., Ltd, Lianyungang, Jiangsu, China.; The National & Local Joint Engineering Research Center on the Intelligent manufacturing of TCM, Lianyungang, Jiangsu, China. |
| المصدر: | Natural product research [Nat Prod Res] 2024 Sep; Vol. 38 (17), pp. 2927-2933. Date of Electronic Publication: 2023 Apr 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Angelica*/chemistry , Plant Roots*/chemistry , Coumarins*/chemistry , Coumarins*/pharmacology , Coumarins*/isolation & purification , Nitric Oxide*/biosynthesis, RAW 264.7 Cells ; Mice ; Animals ; Molecular Structure ; Lipopolysaccharides/pharmacology ; Circular Dichroism |
| مستخلص: | Three undescribed coumarins, 6-(3-hydroxy-3-methyl-2-oxobutyl)-7-methoxycoumarin ( 1 ), (R)-6-(1,3-dihydroxy-3-methyl-2-oxobutyl)-7-methoxycoumarin ( 2 ), angelol N ( 6 ), together with four known coumarins were isolated from the roots of Angelica pubescens . Their structures were determined by extensive spectroscopic analyses. The absolute configurations of compounds 2 and 6 were assigned via electronic circular dichroism (ECD). Their inhibitory effects on lipopoly-saccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. Compounds 1 - 4 exhibited moderate inhibitory activities. |
| فهرسة مساهمة: | Keywords: Angelica pubescens; ECD; RAW264.7 cells; coumarins |
| المشرفين على المادة: | 0 (Coumarins) 31C4KY9ESH (Nitric Oxide) 0 (Lipopolysaccharides) |
| تواريخ الأحداث: | Date Created: 20230412 Date Completed: 20240909 Latest Revision: 20240909 |
| رمز التحديث: | 20240910 |
| DOI: | 10.1080/14786419.2023.2200185 |
| PMID: | 37042679 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2023.2200185 |