دورية أكاديمية
أعرض في EDS

The Local Tumor Microbiome Is Associated with Survival in Late-Stage Colorectal Cancer Patients.

التفاصيل البيبلوغرافية
العنوان: The Local Tumor Microbiome Is Associated with Survival in Late-Stage Colorectal Cancer Patients.
المؤلفون: Debelius JW; Centre for Translational Microbiome Research, Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Solna, Sweden.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Engstrand L; Centre for Translational Microbiome Research, Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Solna, Sweden., Matussek A; Laboratory Medicine, Jönköping Region County, Department of Clinical and Experimental Medicine, Linköping University, Jönköping, Sweden.; Division of Laboratory Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Microbiology, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway., Brusselaers N; Centre for Translational Microbiome Research, Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Solna, Sweden.; Global Health Institute, Antwerp University, Antwerp, Belgium.; Department of Head and Skin, Ghent University, Ghent, Belgium., Morton JT; Biostatistics and Bioinformatics Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA., Stenmarker M; Futurum/Department of Pediatrics, Jönköping Region County, Jönköping, Sweden.; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.; Institute of Clinical Sciences, Department of Paediatrics, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden., Olsen RS; Centre for Translational Microbiome Research, Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Solna, Sweden.; Pathology Laboratory, Department of Laboratory Medicine, Jönköping Region County, Jönköping, Sweden.; Department of Pathology, Division of Laboratory Medicine, Oslo University Hospital, Norwegian Radium Hospital, Oslo, Norway.
المصدر: Microbiology spectrum [Microbiol Spectr] 2023 Jun 15; Vol. 11 (3), pp. e0506622. Date of Electronic Publication: 2023 Apr 12.
نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : ASM Press, 2013-
مواضيع طبية MeSH: Colorectal Neoplasms* , Microbiota*/genetics , Gastrointestinal Microbiome*/genetics, Humans ; Case-Control Studies ; RNA, Ribosomal, 16S/genetics
مستخلص: The gut microbiome is associated with survival in colorectal cancer. Single organisms have been identified as markers of poor prognosis. However, in situ imaging of tumors demonstrate a polymicrobial tumor-associated community. To understand the role of these polymicrobial communities in survival, we conducted a nested case-control study in late-stage cancer patients undergoing resection for primary adenocarcinoma. The microbiome of paired tumor and adjacent normal tissue samples was profiled using 16S rRNA sequencing. We found a consistent difference in the microbiome between paired tumor and adjacent tissue, despite strong individual microbial identities. Furthermore, a larger difference between normal and tumor tissue was associated with prognosis: patients with shorter survival had a larger difference between normal and tumor tissue. Within the tumor tissue, we identified a 39-member community statistic associated with survival; for every log 2 -fold increase in this value, an individual's odds of survival increased by 20% (odds ratio survival 1.20; 95% confidence interval = 1.04 to 1.33). Our results suggest that a polymicrobial tumor-specific microbiome is associated with survival in late-stage colorectal cancer patients. IMPORTANCE Microbiome studies in colorectal cancer (CRC) have primarily focused on the role of single organisms in cancer progression. Recent work has identified specific organisms throughout the intestinal tract, which may affect survival; however, the results are inconsistent. We found differences between the tumor microbiome and the microbiome of the rest of the intestine in patients, and the magnitude of this difference was associated with survival, or, the more like a healthy gut a tumor looked, the better a patient's prognosis. Our results suggest that future microbiome-based interventions to affect survival in CRC will need to target the tumor community.
Competing Interests: The authors declare no conflict of interest.
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فهرسة مساهمة: Keywords: 16S rRNA sequening; cancer survival; colorectal cancer; microbiome; tumor microbiome
المشرفين على المادة: 0 (RNA, Ribosomal, 16S)
تواريخ الأحداث: Date Created: 20230412 Date Completed: 20230619 Latest Revision: 20231120
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10269740
DOI: 10.1128/spectrum.05066-22
PMID: 37042765
قاعدة البيانات: MEDLINE
الوصف
تدمد:2165-0497
DOI:10.1128/spectrum.05066-22