دورية أكاديمية
Atypical Familial Mediterranean Fever Presenting with Recurrent Upper Back Pain: A Case Report.
| العنوان: | Atypical Familial Mediterranean Fever Presenting with Recurrent Upper Back Pain: A Case Report. |
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| المؤلفون: | Matsumoto H; Department of Rheumatology, Fukushima Medical University School of Medicine., Saito K; Department of Rheumatology, Fukushima Medical University School of Medicine., Sumichika Y; Department of Rheumatology, Fukushima Medical University School of Medicine., Yoshida S; Department of Rheumatology, Fukushima Medical University School of Medicine., Temmoku J; Department of Rheumatology, Fukushima Medical University School of Medicine., Fujita Y; Department of Rheumatology, Fukushima Medical University School of Medicine., Matsuoka N; Department of Rheumatology, Fukushima Medical University School of Medicine., Asano T; Department of Rheumatology, Fukushima Medical University School of Medicine., Sato S; Department of Rheumatology, Fukushima Medical University School of Medicine., Migita K; Department of Rheumatology, Fukushima Medical University School of Medicine. |
| المصدر: | The Tohoku journal of experimental medicine [Tohoku J Exp Med] 2023 Jun 09; Vol. 260 (2), pp. 165-169. Date of Electronic Publication: 2023 Apr 13. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Tohoku University Medical Library Country of Publication: Japan NLM ID: 0417355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-3329 (Electronic) Linking ISSN: 00408727 NLM ISO Abbreviation: Tohoku J Exp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Sendai : Tohoku University Medical Library |
| مواضيع طبية MeSH: | Familial Mediterranean Fever*/complications , Familial Mediterranean Fever*/diagnosis , Familial Mediterranean Fever*/drug therapy , Serositis*/drug therapy , Arthritis*/drug therapy , Synovitis*/drug therapy, Humans ; Female ; Adult ; Colchicine/therapeutic use ; Back Pain/etiology ; Back Pain/drug therapy ; Pyrin/genetics |
| مستخلص: | Familial Mediterranean fever (FMF) is a genetic autoinflammatory disease that is characterized by recurrent episodes of fever, serositis, and synovitis. FMF synovitis attacks resemble the clinical presentation of acute monoarthritis with pain and hydrarthrosis, which always resolve spontaneously. In most cases, colchicine will prevent these painful arthritis attacks in FMF. However, distinguishing these arthritis episodes from other febrile attacks with various clinical manifestations, including serositis, is important. We describe a Japanese patient with FMF who presented a febrile attack with severe abdominal and upper back pain (peri-scapula lesion), without any other joint involvement. A 44-year-old female patient presented with recurrent episodes of fever with abdominal and back pain. She carried heterozygous variants in exon 3 of the MEFV gene (P369S/R408Q). She was diagnosed with FMF according to Tel-Hashomer's diagnostic criteria for FMF. Colchicine treatment improved her febrile attcks with peritonitis, however, severe back pain was sustained. This unique aspect of severe pain attack was successfully resolved by canakinumab treatment, which is a specific interleukin-1β monoclonal antibody, and was finally diagnosed as FMF-related shoulder joint synovitis. Further investigations were needed to evaluate the effectiveness of interleukin-1 antagonists against colchicine-resistant arthritis in FMF patients. |
| فهرسة مساهمة: | Keywords: atypical arthritis; biologic; canakinumab; familial Mediterranean fever |
| المشرفين على المادة: | SML2Y3J35T (Colchicine) 0 (MEFV protein, human) 0 (Pyrin) |
| تواريخ الأحداث: | Date Created: 20230412 Date Completed: 20230613 Latest Revision: 20230613 |
| رمز التحديث: | 20230613 |
| DOI: | 10.1620/tjem.2023.J030 |
| PMID: | 37045785 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1349-3329 |
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| DOI: | 10.1620/tjem.2023.J030 |