دورية أكاديمية
أعرض في EDS

Oestrogen and Vibration Improve Intervertebral Disc Cell Viability and Decrease Catabolism in Bovine Organ Cultures.

التفاصيل البيبلوغرافية
العنوان: Oestrogen and Vibration Improve Intervertebral Disc Cell Viability and Decrease Catabolism in Bovine Organ Cultures.
المؤلفون: Widmayer F; Institute of Orthopaedic Research and Biomechanics, University of Ulm, 89081 Ulm, Germany., Neidlinger-Wilke C; Institute of Orthopaedic Research and Biomechanics, University of Ulm, 89081 Ulm, Germany., Witz F; Institute of Orthopaedic Research and Biomechanics, University of Ulm, 89081 Ulm, Germany., Jansen JU; Institute of Orthopaedic Research and Biomechanics, University of Ulm, 89081 Ulm, Germany., Ignatius A; Institute of Orthopaedic Research and Biomechanics, University of Ulm, 89081 Ulm, Germany., Haffner-Luntzer M; Institute of Orthopaedic Research and Biomechanics, University of Ulm, 89081 Ulm, Germany., Teixeira GQ; Institute of Orthopaedic Research and Biomechanics, University of Ulm, 89081 Ulm, Germany.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Mar 24; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Intervertebral Disc*/metabolism , Intervertebral Disc Degeneration*/metabolism, Animals ; Cattle ; Female ; Humans ; Interleukin-6/metabolism ; Cell Survival ; Vibration ; Organ Culture Techniques ; Estrogens/pharmacology ; Estrogens/metabolism
مستخلص: Postmenopausal women are at an increased risk for intervertebral disc degeneration, possibly due to the decrease in oestrogen levels. Low-magnitude, high-frequency vibration (LMHFV) is applied as a therapeutic approach for postmenopausal osteoporosis; however, less is known regarding possible effects on the intervertebral disc (IVD) and whether these may be oestrogen-dependent. The present study investigated the effect of 17β-oestradiol (E2) and LMHFV in an IVD organ culture model. Bovine IVDs ( n = 6 IVDs/group) were treated with either (i) E2, (ii) LMHFV or (iii) the combination of E2 + LMHFV for 2 or 14 days. Minor changes in gene expression, cellularity and matrix metabolism were observed after E2 treatment, except for a significant increase in matrix metalloproteinase (MMP)-3 and interleukin (IL)-6 production. Interestingly, LMHFV alone induced cell loss and increased IL-6 production compared to the control. The combination of E2 + LMHFV induced a protective effect against cell loss and decreased IL-6 production compared to the LMHFV group. This indicates possible benefits of oestrogen therapy for the IVDs of postmenopausal women undergoing LMHFV exercises.
References: J Steroid Biochem Mol Biol. 2016 Apr;158:46-55. (PMID: 26815911)
J Clin Invest. 1956 Jun;35(6):579-87. (PMID: 13319493)
Exp Cell Res. 2005 Apr 15;305(1):83-98. (PMID: 15777790)
Biochem J. 1974 Feb;137(2):387-98. (PMID: 4207388)
Front Bioeng Biotechnol. 2020 Jun 10;8:583. (PMID: 32587853)
Nihon Seikeigeka Gakkai Zasshi. 1985 Dec;59(12):1119-31. (PMID: 3834021)
Spine (Phila Pa 1976). 2019 May 1;44(9):E510-E519. (PMID: 30325885)
Osteoarthritis Cartilage. 2015 Jul;23(7):1057-70. (PMID: 25827971)
Biochem Biophys Res Commun. 2018 Sep 18;503(4):2678-2684. (PMID: 30093109)
Eur Spine J. 2019 May;28(5):922-933. (PMID: 30689044)
Methods. 2001 Dec;25(4):402-8. (PMID: 11846609)
Lancet. 2015 Nov 28;386(10009):2145-91. (PMID: 26321261)
J Orthop Translat. 2016 Dec 01;11:39-52. (PMID: 29662768)
J Occup Health. 2010;52(1):23-30. (PMID: 20009418)
Lancet. 2016 Oct 8;388(10053):1545-1602. (PMID: 27733282)
J Orthop Translat. 2016 Jun 14;8:1-4. (PMID: 30035087)
Spine J. 2009 Jun;9(6):470-7. (PMID: 19356986)
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2496-500. (PMID: 3458212)
BMC Musculoskelet Disord. 2008 Feb 25;9:24. (PMID: 18298830)
Apoptosis. 2014 May;19(5):789-800. (PMID: 24435756)
J Invest Surg. 2021 Aug;34(8):904-911. (PMID: 32036721)
Inflammation. 2021 Apr;44(2):506-517. (PMID: 32965648)
Arthritis Rheum. 2013 Jul;65(7):1853-64. (PMID: 23661269)
Arthritis Rheum. 2012 Jun;64(6):2028-37. (PMID: 22231424)
Menopause. 2017 Oct;24(10):1136-1144. (PMID: 28609385)
Dis Model Mech. 2015 Jan;8(1):93-104. (PMID: 25381012)
J Orthop Res. 2014 Aug;32(8):1006-13. (PMID: 24729351)
BMC Musculoskelet Disord. 2002;3:4. (PMID: 11846890)
JOR Spine. 2022 Nov 14;6(1):e1231. (PMID: 36994466)
Arthritis Rheumatol. 2015 May;67(8):2164-75. (PMID: 25891852)
J Pathol. 2004 Sep;204(1):47-54. (PMID: 15307137)
Int J Biol Sci. 2017 Jan 15;13(2):145-156. (PMID: 28255267)
Acta Biochim Biophys Sin (Shanghai). 2018 Apr 1;50(4):345-354. (PMID: 29529124)
Oncotarget. 2017 Jun 13;8(24):38136-38144. (PMID: 28430617)
Artif Cells Nanomed Biotechnol. 2018;46(sup2):182-191. (PMID: 30056756)
Cell Physiol Biochem. 2016;39(6):2216-2226. (PMID: 27832635)
Life Sci. 2021 Nov 1;284:119874. (PMID: 34390725)
Eur Spine J. 2021 Aug;30(8):2247-2256. (PMID: 34169354)
Eur Rev Med Pharmacol Sci. 2021 Feb;25(4):1811-1820. (PMID: 33660790)
Spine (Phila Pa 1976). 2009 Apr 20;34(9):934-40. (PMID: 19532001)
Eur Spine J. 2009 Nov;18(11):1573-86. (PMID: 19466462)
Eur Cell Mater. 2021 Jul 8;42:1-19. (PMID: 34235715)
Spine (Phila Pa 1976). 2020 Mar 1;45(5):292-299. (PMID: 31809475)
Spine (Phila Pa 1976). 2004 Dec 1;29(23):2603-11. (PMID: 15564908)
J Occup Rehabil. 2014 Jun;24(2):370-81. (PMID: 23975061)
Climacteric. 2014 Dec;17(6):700-4. (PMID: 25017806)
Biomater Adv. 2022 Dec;143:213192. (PMID: 36403438)
Sci Rep. 2015 Mar 11;5:8994. (PMID: 25759206)
Mol Med Rep. 2019 Aug;20(2):1523-1530. (PMID: 31257459)
Osteoarthritis Cartilage. 2017 May;25(5):779-789. (PMID: 28104539)
J Biol Chem. 2014 Aug 15;289(33):22636-22647. (PMID: 24958722)
Prz Menopauzalny. 2015 Mar;14(1):41-7. (PMID: 26327887)
Eur Spine J. 2008 Jan;17(1):2-19. (PMID: 17632738)
Climacteric. 2015 Jun;18(3):435. (PMID: 25728704)
J Orthop Translat. 2015 Sep 28;3(4):205-211. (PMID: 30035059)
Semin Arthritis Rheum. 1983 Aug;13(1):1-86. (PMID: 6138859)
Joint Bone Spine. 2014 May;81(3):250-3. (PMID: 24838202)
Animal Model Exp Med. 2021 Mar 23;4(2):77-86. (PMID: 34179716)
JOR Spine. 2019 Sep 02;2(3):e1065. (PMID: 31572982)
Sci Rep. 2016 Sep 22;6:33836. (PMID: 27652931)
Apoptosis. 2015 Mar;20(3):348-57. (PMID: 25576195)
Tissue Eng Part C Methods. 2016 Jan;22(1):8-19. (PMID: 26565141)
معلومات مُعتمدة: KNMÜ.031.02 Financial Support Programmes for Female Researchers, Office for Gender Equality, Ulm University
فهرسة مساهمة: Keywords: 17β-oestradiol; anabolism; catabolism; intervertebral disc; matrix metalloproteinases; matrix proteins; oestrogen; organ culture; vibration
المشرفين على المادة: 0 (Interleukin-6)
0 (Estrogens)
تواريخ الأحداث: Date Created: 20230413 Date Completed: 20230414 Latest Revision: 20230415
رمز التحديث: 20230415
مُعرف محوري في PubMed: PMC10094023
DOI: 10.3390/ijms24076143
PMID: 37047116
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms24076143