دورية أكاديمية
أعرض في EDS

DNA methylation epi-signature and biological age in attention deficit hyperactivity disorder patients.

التفاصيل البيبلوغرافية
العنوان: DNA methylation epi-signature and biological age in attention deficit hyperactivity disorder patients.
المؤلفون: Carvalho GFDS; Laboratorio de Citogenomica, Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. Electronic address: gleyson.carvalho@usp.br., Costa TVMM; Laboratorio de Citogenomica, Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Nascimento AM; Laboratorio de Citogenomica, Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Wolff BM; Laboratorio de Citogenomica, Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Damasceno JG; Laboratorio de Citogenomica, Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Vieira LL; Laboratorio de Citogenomica, Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Almeida VT; Laboratorio de Citogenomica, Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Oliveira YG; Laboratorio de Citogenomica, Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., Mello CB; Nucleo de Atendimento Neuropsicologico Infantil Interdisciplinar (NANI), Centro Paulista de Neuropsicologia, Departamento de Psicobiologia da Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil., Muszkat M; Nucleo de Atendimento Neuropsicologico Infantil Interdisciplinar (NANI), Centro Paulista de Neuropsicologia, Departamento de Psicobiologia da Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil., Kulikowski LD; Laboratorio de Citogenomica, Departamento de Patologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
المصدر: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2023 May; Vol. 228, pp. 107714. Date of Electronic Publication: 2023 Apr 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7502039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6968 (Electronic) Linking ISSN: 03038467 NLM ISO Abbreviation: Clin Neurol Neurosurg Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Assen, Van Gorcum.
مواضيع طبية MeSH: DNA Methylation*/genetics , Attention Deficit Disorder with Hyperactivity*/genetics , Attention Deficit Disorder with Hyperactivity*/metabolism, Child ; Humans ; Epigenesis, Genetic ; Biomarkers/metabolism ; Aging
مستخلص: Objective: Attention Deficit/Hyperactivity Disorder (ADHD) is a common behavioral syndrome that begins in childhood and affects 3.4% of children worldwide. Due to its etiological complexity, there are no consistent biomarkers for ADHD, however the high heritability presented by the disorder indicates a genetic/epigenetic influence. The main epigenetic mechanism is DNA methylation, a process with an important role in gene expression and in many psychiatric disorders. Thus, our study sought to identify epi-signatures biomarkers in 29 children clinically diagnosed with ADHD.
Methods: After DNA extraction and bisulfite conversion, we performed methylation array experiment for differential methylation, ontological and biological age analysis.
Results: The biological response in ADHD patients was not sufficient to determine a conclusive epi-signature in our study. However, our results highlighted the interaction of energy metabolism and oxidative stress pathways in ADHD patients detected by differential methylation patterns. Furthermore, we were able to identify a marginal association between the DNAmAge and ADHD.
Conclusion: Our study present new methylation biomarkers findings associated with energy metabolism and oxidative stress pathways, in addition to DNAmAge in ADHD patients. However, we propose that further multiethnic studies, with larger cohorts and including maternal conditions, are necessary to demonstrate a definitive association between ADHD and these methylation biomarkers.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: ADHD; DNAmAge; Epi-signature; Epigenetic; Methylation
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20230413 Date Completed: 20230425 Latest Revision: 20230509
رمز التحديث: 20240628
DOI: 10.1016/j.clineuro.2023.107714
PMID: 37054476
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-6968
DOI:10.1016/j.clineuro.2023.107714