دورية أكاديمية
Inhibition of Gluconeogenesis by Boldine in the Perfused Liver: Therapeutical Implication for Glycemic Control.
| العنوان: | Inhibition of Gluconeogenesis by Boldine in the Perfused Liver: Therapeutical Implication for Glycemic Control. |
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| المؤلفون: | Silva LCL; Department of Biochemistry, Labor of Hepatic Metabolism, State University of Maringá, Maringá, PR, Brazil., de Souza GH; Department of Biochemistry, Labor of Hepatic Metabolism, State University of Maringá, Maringá, PR, Brazil., Pateis VO; Department of Biochemistry, Labor of Hepatic Metabolism, State University of Maringá, Maringá, PR, Brazil., Ames-Sibin AP; Department of Biochemistry, Labor of Hepatic Metabolism, State University of Maringá, Maringá, PR, Brazil., Silva BP; Department of Biochemistry, Labor of Hepatic Metabolism, State University of Maringá, Maringá, PR, Brazil., Bracht L; Department of Biochemistry, Labor of Hepatic Metabolism, State University of Maringá, Maringá, PR, Brazil., Comar JF; Department of Biochemistry, Labor of Hepatic Metabolism, State University of Maringá, Maringá, PR, Brazil., Peralta RM; Department of Biochemistry, Labor of Hepatic Metabolism, State University of Maringá, Maringá, PR, Brazil., Bracht A; Department of Biochemistry, Labor of Hepatic Metabolism, State University of Maringá, Maringá, PR, Brazil., Sá-Nakanishi AB; Department of Biochemistry, Labor of Hepatic Metabolism, State University of Maringá, Maringá, PR, Brazil. |
| المصدر: | International journal of hepatology [Int J Hepatol] 2023 Apr 04; Vol. 2023, pp. 1283716. Date of Electronic Publication: 2023 Apr 04 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101564967 Publication Model: eCollection Cited Medium: Print ISSN: 2090-3448 (Print) NLM ISO Abbreviation: Int J Hepatol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Hindawi Pub. Corp. |
| مستخلص: | The alkaloid boldine occurs in the Chilean boldo tree ( Peumus boldus ). It acts as a free radical scavenger and controls glycemia in diabetic rats. Various mechanisms have been proposed for this effect, including inhibited glucose absorption, stimulated insulin secretion, and increased expression of genes involved in glycemic control. Direct effects on glucose synthesis and degradation were not yet measured. To fill this gap, the present study is aimed at ensuring several metabolic pathways linked to glucose metabolism (e.g., gluconeogenesis) in the isolated perfused rat liver. In order to address mechanistic issues, energy transduction in isolated mitochondria and activities of gluconeogenic key enzymes in tissue preparations were also measured. Boldine diminished mitochondrial ROS generation, with no effect on energy transduction in isolated mitochondria. It inhibited, however, at least three enzymes of the gluconeogenic pathway, namely, phosphoenolpyruvate carboxykinase, fructose-bisphosphatase-1, and glucose 6-phosphatase, starting at concentrations below 50 μ M. Consistently, in the perfused liver, boldine decreased lactate-, alanine-, and fructose-driven gluconeogenesis with IC Competing Interests: The authors declare that they have no conflicts of interest. (Copyright © 2023 Laís Cristina Lima Silva et al.) |
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| تواريخ الأحداث: | Date Created: 20230414 Latest Revision: 20230415 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10089784 |
| DOI: | 10.1155/2023/1283716 |
| PMID: | 37056327 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2090-3448 |
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| DOI: | 10.1155/2023/1283716 |