دورية أكاديمية
أعرض في EDS

Visualizing intratumoral injections in lung tumors by endobronchial ultrasound.

التفاصيل البيبلوغرافية
العنوان: Visualizing intratumoral injections in lung tumors by endobronchial ultrasound.
المؤلفون: Mori V; Vermont Lung Center, Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA., DuComb EA; Vermont Lung Center, Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA., Wagner S; Vermont Lung Center, Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA., Khan F; Division of Hematology and Oncology, Department of Medicine, University of Vermont, Burlington VT 05405., Bates JHT; Vermont Lung Center, Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA., Kinsey CM; Vermont Lung Center, Pulmonary and Critical Care Medicine, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA.
المصدر: Journal of Cancer [J Cancer] 2023 Feb 22; Vol. 14 (4), pp. 544-553. Date of Electronic Publication: 2023 Feb 22 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101535920 Publication Model: eCollection Cited Medium: Print ISSN: 1837-9664 (Print) Linking ISSN: 18379664 NLM ISO Abbreviation: J Cancer Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Wyoming, N.S.W. : Ivyspring International Publisher, 2010-
مستخلص: Real-time endobronchial ultrasound images are crucial for the accurate placement of the needle in peribronchial lung tumors and lymph nodes for diagnostic sampling. Beyond its role as a diagnostic tool, ultrasound-guided bronchoscopy can also aid the delivery of anti-cancer agents intratumorally, enabling diagnosis, staging, and treatment to occur within the same anesthesia, reducing the patient's burden. However, determining drug retention and distribution in situ remains challenging, albeit pivotal in assessing the success or failure of the therapeutic intervention. We hypothesized that ultrasound images acquired by the bronchoscope during the injection can provide qualitative and quantitative real-time information about drug transport. As a proof-of-concept, we retrospectively analyzed 13 videos of intratumoral cisplatin injections in advanced non-small cell lung cancers. We identified the injection and performed quantitative analysis through image processing and segmentation algorithms and mathematical models in 5 of them. We were able to infer the unlikeliness of a laminar flow through interstitial pores in favor of the emergence of tissue fractures. These data imply that the structural integrity of the tumor is a critical determinant of the ultimate distribution of an intratumorally delivered agent.
Competing Interests: Competing Interests: VM is a consultant for Johnson & Johnson and co-applicant on the patent "Methods for Guiding Direct Delivery of Drugs and/or Energy to Lesions Using Computational Modeling." U.S. Patent Application No. 62/864,308. Filed June 20, 2019. JHTB is a consultant for Johnson & Johnson and co-applicant on the patent application "Methods for computational modeling to guide intratumoral therapy." U.S. Patent Application No. 62/542,623. Filed: August 8, 2017 and a co-applicant on the patent "Methods for Guiding Direct Delivery of Drugs and/or Energy to Lesions Using Computational Modeling." U.S. Patent Application No. 62/864,308. Filed June 20, 2019. CMK is a consultant for Olympus America, Johnson and Johnson, and consultant and equity holder for Quantitative Imaging Solutions. He serves on the steering committee for Nuvaira and the Scientific Advisory Board for Galvanize Therapeutics. He reports grants from the NIH, clinical trial funding through Johnson and Johnson, a co-applicant on the patent application "Methods for computational modeling to guide intratumoral therapy". U.S. Patent Application No. 62/542,623. Filed: August 8, 2017 and a co-applicant on the patent "Methods for Guiding Direct Delivery of Drugs and/or Energy to Lesions Using Computational Modeling." U.S. Patent Application No. 62/864,308. Filed June 20, 2019. EAD, SW and FK declare that there is no conflict of interest.
(© The author(s).)
References: Nat Commun. 2022 Jan 10;13(1):109. (PMID: 35013154)
Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2205983119. (PMID: 36037341)
Adv Drug Deliv Rev. 2022 Oct;189:114505. (PMID: 36007674)
Trends Cancer. 2018 Apr;4(4):292-319. (PMID: 29606314)
Br J Cancer. 1998 Dec;78(11):1442-8. (PMID: 9836476)
J Biomech. 2010 Jun 18;43(9):1823-6. (PMID: 20211469)
Sci Rep. 2019 May 2;9(1):6819. (PMID: 31048709)
Cancers (Basel). 2022 Feb 18;14(4):. (PMID: 35205794)
Pharm Res. 1996 Oct;13(10):1438-44. (PMID: 8899832)
Cancer Res. 1974 Oct;34(10):2814-22. (PMID: 4369924)
PLoS One. 2014 Apr 28;9(4):e94919. (PMID: 24776986)
Biochem Biophys Res Commun. 2018 Jan 15;495(3):2344-2349. (PMID: 29274784)
J Immunother Cancer. 2021 Feb;9(2):. (PMID: 33589526)
J Thorac Dis. 2020 Sep;12(9):4825-4832. (PMID: 33145055)
J Immunol. 2017 Jan 1;198(1):31-39. (PMID: 27994166)
Sci Transl Med. 2019 Jun 26;11(498):. (PMID: 31243150)
J Mech Behav Biomed Mater. 2012 Feb;6:139-47. (PMID: 22301183)
JAMA Netw Open. 2020 Jul 1;3(7):e207911. (PMID: 32725245)
IEEE Trans Biomed Eng. 2020 Aug;67(8):2337-2348. (PMID: 31841399)
فهرسة مساهمة: Keywords: Drug Dynamics; EBUS-TBNI; Intratumoral Chemotherapy
تواريخ الأحداث: Date Created: 20230414 Latest Revision: 20230415
رمز التحديث: 20230415
مُعرف محوري في PubMed: PMC10088536
DOI: 10.7150/jca.81793
PMID: 37057292
قاعدة البيانات: MEDLINE
الوصف
تدمد:1837-9664
DOI:10.7150/jca.81793