دورية أكاديمية
أعرض في EDS

Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability.

التفاصيل البيبلوغرافية
العنوان: Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability.
المؤلفون: Mansilla SF; Fundación Instituto Leloir, CONICET, 1405 Buenos Aires, Argentina., Bertolin AP; Fundación Instituto Leloir, CONICET, 1405 Buenos Aires, Argentina.; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Venerus Arbilla S; Fundación Instituto Leloir, CONICET, 1405 Buenos Aires, Argentina., Castaño BA; Department of Obstetrics and Gynecology, Ulm University, 89075 Ulm, Germany., Jahjah T; Université Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LRS/iRCM/IBFJ, F-92265 Fontenay-aux-Roses, France.; Université Paris-Saclay, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LRS/iRCM/IBFJ, F-92265 Fontenay-aux-Roses, France., Singh JK; Université Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LRS/iRCM/IBFJ, F-92265 Fontenay-aux-Roses, France.; Université Paris-Saclay, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LRS/iRCM/IBFJ, F-92265 Fontenay-aux-Roses, France., Siri SO; Fundación Instituto Leloir, CONICET, 1405 Buenos Aires, Argentina., Castro MV; Fundación Instituto Leloir, CONICET, 1405 Buenos Aires, Argentina., de la Vega MB; Fundación Instituto Leloir, CONICET, 1405 Buenos Aires, Argentina., Quinet A; Université Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LRS/iRCM/IBFJ, F-92265 Fontenay-aux-Roses, France.; Université Paris-Saclay, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LRS/iRCM/IBFJ, F-92265 Fontenay-aux-Roses, France., Wiesmüller L; Department of Obstetrics and Gynecology, Ulm University, 89075 Ulm, Germany., Gottifredi V; Fundación Instituto Leloir, CONICET, 1405 Buenos Aires, Argentina.
المصدر: Science advances [Sci Adv] 2023 Apr 14; Vol. 9 (15), pp. eade7997. Date of Electronic Publication: 2023 Apr 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]-
مواضيع طبية MeSH: DNA-Directed DNA Polymerase*/genetics , DNA-Directed DNA Polymerase*/metabolism , DNA Replication*, Humans ; DNA/genetics ; DNA/metabolism ; DNA Repair ; DNA Damage ; Chromosomal Instability ; DNA Primase/genetics ; DNA Primase/metabolism ; Multifunctional Enzymes/genetics ; Multifunctional Enzymes/metabolism
مستخلص: Recent studies have described a DNA damage tolerance pathway choice that involves a competition between PrimPol-mediated repriming and fork reversal. Screening different translesion DNA synthesis (TLS) polymerases by the use of tools for their depletion, we identified a unique role of Pol ι in regulating such a pathway choice. Pol ι deficiency unleashes PrimPol-dependent repriming, which accelerates DNA replication in a pathway that is epistatic with ZRANB3 knockdown. In Pol ι-depleted cells, the excess participation of PrimPol in nascent DNA elongation reduces replication stress signals, but thereby also checkpoint activation in S phase, triggering chromosome instability in M phase. This TLS-independent function of Pol ι requires its PCNA-interacting but not its polymerase domain. Our findings unravel an unanticipated role of Pol ι in protecting the genome stability of cells from detrimental changes in DNA replication dynamics caused by PrimPol.
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المشرفين على المادة: EC 2.7.7.7 (DNA-Directed DNA Polymerase)
9007-49-2 (DNA)
EC 2.7.7.- (PrimPol protein, human)
EC 2.7.7.- (DNA Primase)
0 (Multifunctional Enzymes)
تواريخ الأحداث: Date Created: 20230414 Date Completed: 20230418 Latest Revision: 20230421
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10104471
DOI: 10.1126/sciadv.ade7997
PMID: 37058556
قاعدة البيانات: MEDLINE
الوصف
تدمد:2375-2548
DOI:10.1126/sciadv.ade7997