دورية أكاديمية
أعرض في EDS

Survival of Elderly Patients Undergoing Pancreatoduodenectomy in an Integrated Health System.

التفاصيل البيبلوغرافية
العنوان: Survival of Elderly Patients Undergoing Pancreatoduodenectomy in an Integrated Health System.
المؤلفون: Kwak HV; Department of Surgery, University of California San Francisco-East Bay, Oakland, California. Electronic address: hykwak@alamedahealthsystem.org., Dzubnar JM; Department of Surgery, University of California San Francisco-East Bay, Oakland, California., Hsu DS; Department of Surgery, University of California San Francisco-East Bay, Oakland, California., Chang AL; University of California Davis, Davis, California., Spitzer AL; Department of Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California., Kazantsev GB; Department of Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California., Peng PD; Department of Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California., Chang CK; Department of Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California.
المصدر: The Journal of surgical research [J Surg Res] 2023 Aug; Vol. 288, pp. 315-320. Date of Electronic Publication: 2023 Apr 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0376340 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8673 (Electronic) Linking ISSN: 00224804 NLM ISO Abbreviation: J Surg Res Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Academic Press
Original Publication: Philadelphia [etc.]
مواضيع طبية MeSH: Pancreatic Neoplasms*/pathology , Delivery of Health Care, Integrated*, Humans ; Male ; Female ; Aged ; Treatment Outcome ; Pancreaticoduodenectomy/methods ; Retrospective Studies
مستخلص: Introduction: The purpose of this study is to examine pancreatoduodenectomy (PD) perioperative outcomes and consider how age may be related to overall survival in an integrated health system.
Materials and Methods: A retrospective review was performed of 309 patients who underwent PD between December 2008 and December 2019. Patients were divided into two groups: aged 75 y or less and more than 75 y, defined as senior surgical patients. Univariate and multivariable analyses of predictive clinicopathologic factors associated with overall survival at 5 y were performed.
Results: In both groups, the majority underwent PD for malignant disease. The proportion of senior surgical patients alive at 5 y was 33.3% compared to 53.6% of younger patients (P = 0.003). There were also statistically significant differences between the two groups with respect to body mass index, cancer antigen 19-9, Eastern Cooperative Oncology Group performance status, and Charlson comorbidity index. On multivariable analysis, disease type, cancer antigen 19-9, hemoglobin A1c, length of surgery, length of stay, Charlson comorbidity index, and Eastern Cooperative Oncology Group performance status were found to be statistically significant factors for overall survival. Age was not significantly related to overall survival on multivariable logistic regression and when the analysis was limited to pancreatic cancer patients.
Conclusions: Although the difference in overall survival between patients aged less than and more than 75 years was significant, age was not an independent risk factor for overall survival on multivariable analysis. Rather than a patient's chronological age, his/her physiologic age including medical comorbidities and functional status may be more correlated to overall survival.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Elderly; Functional status; Pancreatic cancer; Pancreatoduodenectomy; Survival
تواريخ الأحداث: Date Created: 20230414 Date Completed: 20230515 Latest Revision: 20230531
رمز التحديث: 20240628
DOI: 10.1016/j.jss.2023.03.020
PMID: 37058988
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-8673
DOI:10.1016/j.jss.2023.03.020