دورية أكاديمية

No association between in utero exposure to emissions from a coalmine fire and post-natal lung function.

التفاصيل البيبلوغرافية
العنوان: No association between in utero exposure to emissions from a coalmine fire and post-natal lung function.
المؤلفون: Hemstock EJ; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.; Centre for Air Pollution, Energy and Health Research, NHMRC CRE, Glebe, NSW, Australia., Foong RE; Children's Lung Health, Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Nedlands, WA, Australia.; School of Allied Health, Curtin University, Bentley, WA, Australia., Hall GL; Children's Lung Health, Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Nedlands, WA, Australia.; School of Allied Health, Curtin University, Bentley, WA, Australia., Wheeler AJ; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.; Commonwealth Scientific and Industrial Research Organization, Aspendale, VIC, Australia., Dharmage SC; Allergy and Lung Health Unit, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Dalton M; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Williamson GJ; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Gao C; School of Public Health & Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Orygen Centre for Youth Mental Health, University of Melbourne, Parkville, VIC, Australia., Abramson MJ; School of Public Health & Preventive Medicine, Monash University, Melbourne, VIC, Australia., Johnston FH; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Zosky GR; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia. graeme.zosky@utas.edu.au.; Tasmanian School of Medicine, University of Tasmania, Hobart, TAS, Australia. graeme.zosky@utas.edu.au.
المصدر: BMC pulmonary medicine [BMC Pulm Med] 2023 Apr 14; Vol. 23 (1), pp. 120. Date of Electronic Publication: 2023 Apr 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968563 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2466 (Electronic) Linking ISSN: 14712466 NLM ISO Abbreviation: BMC Pulm Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001]-
مواضيع طبية MeSH: Air Pollutants*/adverse effects , Air Pollutants*/analysis , Air Pollution*/adverse effects, Child ; Humans ; Particulate Matter/analysis ; Prospective Studies ; Environmental Exposure/adverse effects ; Lung ; Respiration
مستخلص: Background and Objective: Studies linking early life exposure to air pollution and subsequent impaired lung health have focused on chronic, low-level exposures in urban settings. We aimed to determine whether in utero exposure to an acute, high-intensity air pollution episode impaired lung function 7-years later.
Method: We conducted a prospective cohort study of children who lived in the vicinity of a coalmine fire. Respiratory function was measured using the forced oscillation technique (FOT). Z-scores for resistance at 5 Hz (R 5 ), reactance at 5 Hz (X 5 ) and area under the reactance curve (AX) were calculated. Two sets of analyses were conducted to address two separate questions: (1) whether mine fire exposure (a binary indicator; conceived after the mine fire vs in utero exposed) was associated with the respiratory Z-scores; (2) whether there was any dose-response relationship between fire-related PM 2.5 exposure and respiratory outcomes among those exposed.
Results: Acceptable lung function measurements were obtained from 79 children; 25 unexposed and 54 exposed in utero. Median (interquartile range) for daily average and peak PM 2.5 for the exposed children were 4.2 (2.6 - 14.2) and 88 (52-225) µg/m 3 respectively. There were no detectable differences in Z-scores between unexposed and exposed children. There were no associations between respiratory Z-scores and in utero exposure to PM 2.5 (daily average or peak).
Conclusion: There was no detectable effect of in utero exposure to PM 2.5 from a local coalmine fire on post-natal lung function 7-years later. However, statistical power was limited.
(© 2023. The Author(s).)
References: Nat Commun. 2019 Sep 17;10(1):3866. (PMID: 31530803)
Environ Health Perspect. 2010 Mar;118(3):432-6. (PMID: 20064770)
Respirology. 2020 Feb;25(2):198-205. (PMID: 31231911)
Environ Res. 2018 Oct;166:150-157. (PMID: 29886391)
Int J Epidemiol. 2021 Jan 23;49(6):1779-1780. (PMID: 33083835)
Environ Int. 2020 Sep;142:105853. (PMID: 32585502)
Toxicol Lett. 2013 Jan 10;216(1):47-53. (PMID: 23164674)
Environ Health Perspect. 2012 Sep;120(9):1340-5. (PMID: 22645279)
Paediatr Perinat Epidemiol. 2010 Sep;24(5):492-501. (PMID: 20670230)
Int J Environ Res Public Health. 2021 Sep 20;18(18):. (PMID: 34574829)
Environ Health Prev Med. 2021 Jul 12;26(1):72. (PMID: 34253165)
Eur J Epidemiol. 2011 Jan;26(1):45-54. (PMID: 20882323)
Tob Control. 2006 Aug;15(4):294-301. (PMID: 16885578)
Int J Environ Res Public Health. 2021 Jul 13;18(14):. (PMID: 34299914)
Lancet Respir Med. 2018 Jul;6(7):535-544. (PMID: 29628376)
Cell Tissue Res. 2017 Mar;367(3):445-455. (PMID: 27726025)
Paediatr Respir Rev. 2017 Jan;21:38-46. (PMID: 27665510)
Pediatr Pulmonol. 2013 Jul;48(7):707-15. (PMID: 23169525)
Environ Health Perspect. 2007 Jul;115(7):989-95. (PMID: 17637911)
Int J Hyg Environ Health. 2015 Oct;218(7):656-65. (PMID: 26220828)
Epidemiology. 2015 Jul;26(4):556-64. (PMID: 25906366)
Int J Environ Res Public Health. 2019 Oct 02;16(19):. (PMID: 31581673)
Am J Respir Crit Care Med. 2007 Jun 15;175(12):1304-45. (PMID: 17545458)
Respir Res. 2018 Apr 27;19(1):76. (PMID: 29703190)
N Engl J Med. 2004 Sep 9;351(11):1057-67. (PMID: 15356303)
معلومات مُعتمدة: RG152952 Centre for Air pollution, energy and health Research, NHMRC Centre of Research Excellence; C3478 Department of Health, State Government of Victoria; C3478 Department of Health, State Government of Victoria
فهرسة مساهمة: Keywords: Early life; In utero exposure; Long-term effects; Particulate matter; Respiratory function
المشرفين على المادة: 0 (Air Pollutants)
0 (Particulate Matter)
تواريخ الأحداث: Date Created: 20230414 Date Completed: 20230418 Latest Revision: 20230418
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10103534
DOI: 10.1186/s12890-023-02414-7
PMID: 37059986
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2466
DOI:10.1186/s12890-023-02414-7