دورية أكاديمية
Effect of freezing of gait and dopaminergic medication in the biomechanics of lower limbs in the gait of patients with Parkinson's disease compared to neurologically healthy.
| العنوان: | Effect of freezing of gait and dopaminergic medication in the biomechanics of lower limbs in the gait of patients with Parkinson's disease compared to neurologically healthy. |
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| المؤلفون: | Shida TKF; Biomedical Engineering, Federal University of ABC, São Bernardo do Campo, SP, Brazil., de Oliveira CEN; Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil., da Silva Fragoso de Campos D; Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil., Los Angeles E; Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil., Bernardo C; Biomedical Engineering, Federal University of ABC, São Bernardo do Campo, SP, Brazil., Dos Santos de Oliveira L; Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil., Salloum E Silva LC; Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil., Novaes TM; Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil., Shokur S; École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; The BioRobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy., Bouri M; The BioRobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant'Anna, Pisa, Italy., Coelho DB; Biomedical Engineering, Federal University of ABC, São Bernardo do Campo, SP, Brazil; Center for Mathematics, Computation and Cognition, Federal University of ABC, São Bernardo do Campo, Brazil. Electronic address: daniel.boari@ufabc.edu.br. |
| المصدر: | Neuroscience letters [Neurosci Lett] 2023 May 29; Vol. 806, pp. 137250. Date of Electronic Publication: 2023 Apr 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Scientific Publishers Ireland Original Publication: Amsterdam, Elsevier/North-Holland. |
| مواضيع طبية MeSH: | Parkinson Disease*/complications , Parkinson Disease*/drug therapy , Parkinson Disease*/diagnosis , Gait Disorders, Neurologic*/drug therapy , Gait Disorders, Neurologic*/etiology, Humans ; Biomechanical Phenomena ; Gait ; Dopamine Agents/therapeutic use ; Lower Extremity |
| مستخلص: | Introduction: This study aims to evaluate the effects of medication, and the freezing of gait (FoG) on the kinematic and kinetic parameters of gait in people with Parkinson's disease (pwPD) compared to neurologically healthy. Methods: Twenty-two people with a clinical diagnosis of idiopathic PD in ON and OFF medication (11 FoG), and 18 healthy participants (control) were selected from two open data sets. All participants walked on the floor on a 10-meter-long walkway. The joint kinematic and ground reaction forces (GRF) variables of gait and the clinical characteristics were compared: (1) PD with FoG (pwFoG) and PD without FoG (pwoFoG) in the ON condition and control; (2) PD with FoG and PD without FoG in the OFF condition and control; (3) Group (PD with FoG and PD without FoG) and Medication. Results: (1) FoG mainly affects distal joints, such as the ankle and knee; (2) PD ON showed changes in the range of motion of both distal and proximal joints, which may explain the increase in step length and gait speed expected with the use of L-Dopa; and (3) the medication showed improvements in the kinematic and kinetic parameters of the gait of people with pwFoG and pwoFoG equally; (4) pwPD showed a smaller second peak of the vertical component of the GRF than the control. Conclusion: The presence of FoG mainly affects distal joints, such as the ankle and knee. PD presents a lower application of GRF during the impulse period than healthy people, causing lower gait performances. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Kinematics; Kinetics; Levodopa; Movement disorders |
| المشرفين على المادة: | 0 (Dopamine Agents) |
| تواريخ الأحداث: | Date Created: 20230415 Date Completed: 20230428 Latest Revision: 20230502 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.neulet.2023.137250 |
| PMID: | 37061024 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7972 |
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| DOI: | 10.1016/j.neulet.2023.137250 |