دورية أكاديمية
Nicotine Intake in Adult Pod E-cigarette Users: Impact of User and Device Characteristics.
| العنوان: | Nicotine Intake in Adult Pod E-cigarette Users: Impact of User and Device Characteristics. |
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| المؤلفون: | Giberson J; Research Program in Clinical Pharmacology, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA, USA., Nardone N; Research Program in Clinical Pharmacology, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA, USA., Addo N; Research Program in Clinical Pharmacology, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA, USA., Khan S; Univiersity of California, Berkeley, CA, USA., Jacob P; Research Program in Clinical Pharmacology, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA, USA.; Center for Tobacco Control Research and Education, University of California, San Francisco, CA, USA.; Tobacco Center of Regulatory Science, University of California, San Francisco, CA, USA., Benowitz N; Research Program in Clinical Pharmacology, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA, USA.; Center for Tobacco Control Research and Education, University of California, San Francisco, CA, USA.; Tobacco Center of Regulatory Science, University of California, San Francisco, CA, USA., St Helen G; Research Program in Clinical Pharmacology, Division of Cardiology, Department of Medicine, University of California, San Francisco, CA, USA.; Center for Tobacco Control Research and Education, University of California, San Francisco, CA, USA.; Tobacco Center of Regulatory Science, University of California, San Francisco, CA, USA. |
| المصدر: | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco [Nicotine Tob Res] 2023 Jul 14; Vol. 25 (8), pp. 1489-1495. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9815751 Publication Model: Print Cited Medium: Internet ISSN: 1469-994X (Electronic) Linking ISSN: 14622203 NLM ISO Abbreviation: Nicotine Tob Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2009->: Oxford : Oxford University Press Original Publication: Abingdon, Oxfordshire, UK : Carfax Pub. and Society for Research on Nicotine and Tobacco, c1999- |
| مواضيع طبية MeSH: | Electronic Nicotine Delivery Systems* , Tobacco Products* , Cigarette Smoking* , Vaping*, Adult ; Humans ; Male ; Female ; Nicotine/analysis ; Surveys and Questionnaires |
| مستخلص: | Introduction: This study examined user behavior, e-cigarette dependence, and device characteristics on nicotine intake among users of pod-mod e-cigarettes. Aims and Methods: In 2019-2020, people who use pod-mods in the San Francisco Bay Area completed questionnaires and provided a urine sample for analysis of total nicotine equivalents (TNE). The relationship between TNE and e-cigarette use, e-cigarette brands, e-liquid nicotine strength, e-cigarette dependence, and urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), as a measure of combustible cigarette exposure, were examined. Results: Of 100 participants (64% male, 71% in the 18-34 age group, 45% white), 53 used JUUL primarily, 12 used Puff Bar primarily, and 35 used other brands, including Suorin; 48 participants reported current cigarette smoking. Participants most often reported use of e-liquid with 4.5%-6.0% nicotine (68%), fruit (35%), tobacco (28%), and menthol or mint flavors (26%), used e-cigarettes on 25.5 (SD = 6.3) days a month, 10.2 (SD = 14.2) times a day, and 40% used 1-2 pods/cartridges per week. In bivariate analysis, urinary TNE was higher with greater frequency (days used) and intensity (number of pods used) of e-cigarette use, e-cigarette dependence, and combustible cigarette use. In multivariable analysis, days of e-cigarette use in the last 30 days, number of pods used per week, and NNAL levels were significantly associated with TNE. There was no significant impact of e-liquid nicotine strength on TNE. Conclusions: Nicotine intake among people who used pod-mod e-cigarettes increased with e-cigarette consumption and e-cigarette dependence, but not with e-liquid nicotine strength. Our findings may inform whether FDA adopts a nicotine standard for e-cigarettes. Implications: The study examined how device and user characteristics influence nicotine intake among pod-mod e-cigarette users. Nicotine intake increased with frequency (days of e-cigarette use in past 30 days) intensity of use (number of pods used per day) and e-cigarette dependence but not with the flavor or nicotine concentration of the e-liquids. Regulation of nicotine concentration of e-liquids is unlikely to influence nicotine exposure among adult experienced pod-mod users. (© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| References: | Addict Behav. 2022 Jan;124:107117. (PMID: 34555560) Nicotine Tob Res. 2023 Feb 9;25(3):498-504. (PMID: 36073762) Nicotine Tob Res. 2020 Jun 12;22(7):1239-1243. (PMID: 31821492) JAMA Pediatr. 2020 Jul 1;174(7):714-720. (PMID: 32478809) Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3421-5. (PMID: 19959691) Toxicol Lett. 2007 Sep 10;173(2):101-6. (PMID: 17716838) Qual Health Res. 2021 Mar;31(4):703-712. (PMID: 33213262) Nicotine Tob Res. 2018 Jul 9;20(8):998-1003. (PMID: 29065196) Cancer Epidemiol Biomarkers Prev. 2018 Mar;27(3):254-261. (PMID: 29475963) Nicotine Tob Res. 2023 Feb 9;25(3):412-420. (PMID: 35965260) Addiction. 2022 Jan;117(1):207-215. (PMID: 34105208) Addiction. 2020 Jun;115(6):1141-1148. (PMID: 31994254) Drug Alcohol Depend. 2019 Aug 1;201:85-93. (PMID: 31200279) Tob Control. 2019 Mar;28(2):146-151. (PMID: 29853561) Nicotine Tob Res. 2020 Feb 6;22(2):288-292. (PMID: 30852610) MMWR Morb Mortal Wkly Rep. 2021 Oct 01;70(39):1387-1389. (PMID: 34591834) Chem Res Toxicol. 2001 Nov;14(11):1465-81. (PMID: 11712903) Nicotine Tob Res. 2004 Apr;6(2):199-205. (PMID: 15203793) N Engl J Med. 2020 Feb 20;382(8):689-691. (PMID: 31951683) Nicotine Tob Res. 2015 Feb;17(2):186-92. (PMID: 25332459) Addiction. 2018 Oct;113(10):1874-1882. (PMID: 29882257) N Engl J Med. 2018 Sep 20;379(12):1099-1102. (PMID: 30134127) |
| معلومات مُعتمدة: | P30 DA012393 United States DA NIDA NIH HHS; U54 HL147127 United States HL NHLBI NIH HHS; 1 U54HL147127 United States HL NHLBI NIH HHS; United States NH NIH HHS |
| المشرفين على المادة: | 6M3C89ZY6R (Nicotine) |
| تواريخ الأحداث: | Date Created: 20230416 Date Completed: 20230717 Latest Revision: 20240416 |
| رمز التحديث: | 20240416 |
| مُعرف محوري في PubMed: | PMC10347964 |
| DOI: | 10.1093/ntr/ntad050 |
| PMID: | 37061820 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1469-994X |
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| DOI: | 10.1093/ntr/ntad050 |