دورية أكاديمية
أعرض في EDS

Megakaryocytes in the lung: History and future perspectives.

التفاصيل البيبلوغرافية
العنوان: Megakaryocytes in the lung: History and future perspectives.
المؤلفون: Livada AC; Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.; Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA., Pariser DN; Division of Comparative Medicine, Massachusetts Institute of Technology, Boston, Massachusetts, USA., Morrell CN; Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.; Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.; Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.; Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
المصدر: Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2023 Jan 19; Vol. 7 (2), pp. 100053. Date of Electronic Publication: 2023 Jan 19 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101703775 Publication Model: eCollection Cited Medium: Internet ISSN: 2475-0379 (Electronic) Linking ISSN: 24750379 NLM ISO Abbreviation: Res Pract Thromb Haemost Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York] : Elsevier
Original Publication: Hoboken, NJ : John Wiley & Sons, Inc., [2017]-
مستخلص: A state of the art lecture titled " Megakaryocytes in the Lung " was presented at the London International Society on Thrombosis and Haemostasis congress in 2022. This lecture highlighted that although most medical teaching presents platelets as bone marrow megakaryocyte-derived cellular mediators of thrombosis, platelets are also a critical part of the immune system with direct roles in responses to sterile tissue injury and pathogens. Bone marrow megakaryocytes differentiate from hematopoietic stem cells and package platelets with immune molecules. Activated platelets, therefore, initiate or accelerate the progression of vascular inflammatory pathologies, as well as being regulators of immune responses to infectious agents. Platelets are now known to have mechanistic roles in immune responses to disease processes, such as heart transplant rejection, myocardial infarction, aortic aneurysm, peripheral vascular disease, and infections. From these studies comes the concept that megakaryocytes are immune cell progenitors and recent emerging information highlights that megakaryocytes may themselves be immune cells. Despite megakaryocytes being described in the lung for >100 years, lung megakaryocytes have only recently been shown to be platelet producing and lung megakaryocytes are immune-differentiated in both phenotype and function. What is still not known is the origin of lung megakaryocytes and roles of lung megakaryocytes in health and disease. This review will discuss the long history of lung megakaryocytes in the literature and potential models for megakaryocyte origins and immune functions. Finally, we summarize relevant new data related to this topic that was presented during the 2022 International Society on Thrombosis and Haemostasis Congress.
(© 2023 The Author(s).)
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معلومات مُعتمدة: F30 HL165822 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: bone marrow; inflammation; lung; megakaryocyte; platelet
تواريخ الأحداث: Date Created: 20230417 Latest Revision: 20240618
رمز التحديث: 20240618
مُعرف محوري في PubMed: PMC10099324
DOI: 10.1016/j.rpth.2023.100053
PMID: 37063766
قاعدة البيانات: MEDLINE
الوصف
تدمد:2475-0379
DOI:10.1016/j.rpth.2023.100053