دورية أكاديمية
أعرض في EDS

Respiratory Syncytial Virus Disease Burden in Community-Dwelling and Long-Term Care Facility Older Adults in Europe and the United States: A Prospective Study.

التفاصيل البيبلوغرافية
العنوان: Respiratory Syncytial Virus Disease Burden in Community-Dwelling and Long-Term Care Facility Older Adults in Europe and the United States: A Prospective Study.
المؤلفون: Narejos Pérez S; CAP Centelles, Centelles, Barcelona, Spain., Ramón Torrell JM; Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain., Põder A; Clinical Research Center, Tartu, Estonia., Leroux-Roels I; Center for Vaccinology, Ghent University Hospital, Ghent, Belgium., Pérez-Breva L; Fundación para el Fomento de la Investigación Sanitaria y Biomédica, Valencia, Spain., Steenackers K; Centre for the Evaluation of Vaccination, University of Antwerp, Antwerp, Belgium., Vandermeulen C; KU Leuven, Leuven University Vaccinology Center, Department of Public Health and Primary Care, Leuven, Belgium., Meisalu S; Innomedica Medical Center, Tallinn, Estonia., McNally D; Ormeau Health Centre, Belfast, UK., Bowen JST; John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK., Heer A; Lakeside Surgery, Lakeside Healthcare, Corby, UK., Beltran Martinez A; Ashgate Medical Practice, Chesterfield, UK., Helman LL; MOC Research, Mishawaka, Indiana, Indiana, USA., Arora A; Haywood Community Hospital-Midlands Partnership NHS Foundation Trust, Stoke-on-Trent, UK., Feldman RG; Senior Clinical Trials, Laguna Hills, California, California, USA., Patel R; Royal South Hants Hospital, Clinical Research Office, Solent NHS Trust, Southampton, UK., Shah A; Piedmont Research Partners, LLC, Fort Mill, South Carolina, USA., Devadiga R; GSK, Bangalore, India., Damaso S; GSK, Wavre, Belgium., Matthews S; Freelance c/o GSK, Wavre, Belgium., Pirçon JY; GSK, Wavre, Belgium., Luyts D; GSK, Wavre, Belgium.
المصدر: Open forum infectious diseases [Open Forum Infect Dis] 2023 Mar 01; Vol. 10 (4), pp. ofad111. Date of Electronic Publication: 2023 Mar 01 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]-
مستخلص: Background: Data on respiratory syncytial virus (RSV) disease burden in adults remain scarce. We assessed the burden of confirmed RSV-acute respiratory infections (cRSV-ARIs) in community-dwelling (CD) adults and those in long-term care facilities (LTCFs).
Methods: In this prospective cohort study covering 2 RSV seasons (October 2019-March 2020 and October 2020-June 2021), RSV-ARIs were identified through active surveillance, in medically stable CD-adults ≥50 years (Europe) or adults ≥65 years in LTCFs (Europe and the United States). RSV infection was confirmed by polymerase chain reaction from combined nasal and throat swabs.
Results: Of 1981 adults enrolled, 1251 adults in CD and 664 LTCFs (season 1) and 1223 adults in CD and 494 LTCFs (season 2) were included in the analyses. During season 1, overall incidence rates ([IRs] cases/1000 person-years) and attack rates (ARs) for cRSV-ARIs were 37.25 (95% confidence interval [CI], 22.62-61.35) and 1.84% in adults in CD and 47.85 (CI, 22.58-101.4) and 2.26% in adults in LTCFs. Complications occurred for 17.4% (CD) and 13.3% (LTCFs) of cRSV-ARIs. One cRSV-ARI occurred in season 2 (IR = 2.91 [CI, 0.40-20.97]; AR = 0.20%), without complications. No cRSV-ARIs led to hospitalization or death. Viral pathogens were codetected in ≤17.4% of cRSV-ARIs.
Conclusions: RSV is an important cause of disease burden in adults in CD and LTCFs. Despite the observed low severity of cRSV-ARI, our results support the need for RSV prevention strategies among adults ≥50 years old.
Competing Interests: Potential conflicts of interest. RD, SD, J-YP, and DL are employees of the GSK group of companies. SD, J-YP, and DL hold shares in the GSK group of companies as part of their employee remuneration. JMRT declares lectures for Pfizer and attending meetings for GSK and Pfizer. IL-R declares funding from GSK, ICOSAVAX, and Virometix to her institution for conducting RSV clinical trials and participation on Janssen advisory boards for RSV vaccines. CV reports grant/research support from GSK to her institution for the conduct of the current study and is currently an employee of the GSK group of companies. KS, JSTB, and LLH declares research funding received by their institution from GSK. RGF declares lectures for GSK. SM works as a freelance consultant on behalf of the GSK group of companies. All other authors declare no conflict of interest.
(© The Author(s) 2023. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.)
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فهرسة مساهمة: Keywords: care facilities; community-dwelling; incidence/burden of disease; older adults; respiratory syncytial virus infection
تواريخ الأحداث: Date Created: 20230417 Latest Revision: 20230418
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10099469
DOI: 10.1093/ofid/ofad111
PMID: 37065988
قاعدة البيانات: MEDLINE
الوصف
تدمد:2328-8957
DOI:10.1093/ofid/ofad111