دورية أكاديمية
In vitro antimicrobial studies of some major bioactive compounds isolated from Strychnos innocua (Delile) root bark.
| العنوان: | In vitro antimicrobial studies of some major bioactive compounds isolated from Strychnos innocua (Delile) root bark. |
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| المؤلفون: | Uttu AJ; Department of Chemistry, Federal University Gashua, Yobe State, Nigeria. Electronic address: jibuttu@yahoo.com., Sallau MS; Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria., Iyun ORA; Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria., Ibrahim H; Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria. |
| المصدر: | Steroids [Steroids] 2023 Jul; Vol. 195, pp. 109241. Date of Electronic Publication: 2023 Apr 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0404536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5867 (Electronic) Linking ISSN: 0039128X NLM ISO Abbreviation: Steroids Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Elsevier Original Publication: San Francisco. |
| مواضيع طبية MeSH: | Strychnos* , Anti-Infective Agents* , Plants, Medicinal*/chemistry, Plant Extracts/chemistry ; Staphylococcus aureus ; Escherichia coli ; Plant Bark ; Bacteria ; Microbial Sensitivity Tests |
| مستخلص: | Plant based therapies are very essential in modern medicine, and have long been used to cure and prevent chronic diseases in many parts of the world. Medicinal herbs have been shown to have biological properties due to the presence of active compounds. Strychnos innocua, a medicinal plant from Loganiaceae, is commonly consumed for medicinal purposes in various African countries. The need to assess the usefulness of the plant's root bark in the treatment of disease spurred this study, which involved the isolation of six bioactive compounds and screening for antimicrobial properties against some pathogens using the agar well diffusion method. Chromatography separation led to first time isolation of Umbelliferone (1), Linalool (2), Nerolidol (3), Campesterol (4), β-sitosterol (5), and 2,13-Octadecadien-1-ol (6). GC-MS and NMR spectra, as well as comparisons with published data, were used to determine their structures. The compounds exhibited strong antimicrobial activity comparable to ciprofloxacin and fluconazole against MRSA, B. subtilis, S. pyogenes, S. aureus, K. pneumoniae, E. coli, P. aeruginosa, S. typhii, A. fumigatus, C. albicans, C. krusei, and A. nigre. The MIC as well as the MBC/MFC were determined. In conclusion, the compounds (1 - 6) isolated from S. innocua root bark have remarkable antibacterial action against pathogenic microbes. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antimicrobial activity; Compounds; Loganiaceae; Strychnos innocua |
| المشرفين على المادة: | 0 (Plant Extracts) 0 (Anti-Infective Agents) |
| تواريخ الأحداث: | Date Created: 20230417 Date Completed: 20230525 Latest Revision: 20230618 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.steroids.2023.109241 |
| PMID: | 37068701 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-5867 |
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| DOI: | 10.1016/j.steroids.2023.109241 |