دورية أكاديمية
Persistent psychosis associated with extreme delta brush in anti-NMDA receptor encephalitis: a case report.
| العنوان: | Persistent psychosis associated with extreme delta brush in anti-NMDA receptor encephalitis: a case report. |
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| المؤلفون: | Nóbrega PR; Division of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará, Ceará, Brazil., Lima PRO; Division of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará, Ceará, Brazil., de Oliveira Junior PH; Division of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará, Ceará, Brazil., Sanders LP; Division of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará, Ceará, Brazil., Sobreira-Neto MA; Division of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará, Ceará, Brazil., Magalhães SC; Division of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará, Ceará, Brazil.; Universidade de Fortaleza, Fortaleza, Brazil., Sanders LLO; Division of Psychiatry, Department of Clinical Medicine, Universidade Federal do Ceará, Ceará, Brazil., Braga-Neto P; Division of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará, Ceará, Brazil. pbraganeto@ufc.br.; Center of Health Sciences, Universidade Estadual do Ceará, Ceará, Brazil. pbraganeto@ufc.br. |
| المصدر: | BMC psychiatry [BMC Psychiatry] 2023 Apr 17; Vol. 23 (1), pp. 256. Date of Electronic Publication: 2023 Apr 17. |
| نوع المنشور: | Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | Anti-N-Methyl-D-Aspartate Receptor Encephalitis*/complications , Anti-N-Methyl-D-Aspartate Receptor Encephalitis*/diagnosis , Psychotic Disorders*/complications , Psychotic Disorders*/diagnosis , Dyskinesias*/complications, Female ; Humans ; Adolescent ; Electroencephalography ; Seizures |
| مستخلص: | Background: Anti-NMDAR encephalitis is an emerging differential diagnosis of first episode and persistent psychosis in the psychiatric community, as clinical manifestations include psychiatric symptoms, cognitive dysfunction, seizures, decreased consciousness, and dyskinesias. This disease is associated with extreme delta brush (EDB), but the significance and temporal course of this EEG pattern still needs to be determined. Herein, we report a case of anti-NMDAR encephalitis with persistent psychosis associated with EDB occurrence on multiple occasions during a 5-year disease course. Case Presentation: A 15-year-old girl was diagnosed with anti-NMDAR encephalitis and treated with progressive improvement. Four years after initial manifestations, an EDB pattern was seen on electroencephalogram (EEG) without new neurological symptoms. She had residual symptoms of episodic auditory hallucinations and impulsivity. One year later, the patient had a recurrence of neurological symptoms (seizures, dyskinesias and impaired attention), persisting with EDB on EEG. Clinical symptoms and EDB resolved after second-line treatment with rituximab. Conclusion: We describe the first case of persistent psychosis in anti-NMDAR encephalitis associated with extreme delta brush on multiple EEGs on prolonged follow-up. Electroencephalographic patterns such as EDB may serve as markers of residual disease activity, including psychiatric symptoms. Further studies with prolonged EEG monitoring are needed to better understand these findings. (© 2023. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Anti-N-Methyl-D-Aspartate receptor encephalitis; Autoimmune diseases; Encephalitis; Extreme delta brush; Seizure |
| تواريخ الأحداث: | Date Created: 20230418 Date Completed: 20230419 Latest Revision: 20230423 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10111700 |
| DOI: | 10.1186/s12888-023-04750-8 |
| PMID: | 37069530 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-244X |
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| DOI: | 10.1186/s12888-023-04750-8 |