دورية أكاديمية
Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits.
العنوان: | Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits. |
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المؤلفون: | Rmus M; University of California, Berkeley, Berkeley, United States., He M; Massachusetts Institute of Technology, Boston, United States., Baribault B; University of California, Berkeley, Berkeley, United States., Walsh EG; Brown University, Providence, United States., Festa EK; Brown University, Providence, United States., Collins AGE; University of California, Berkeley, Berkeley, United States., Nassar MR; Brown University, Providence, United States. |
المصدر: | ELife [Elife] 2023 Apr 18; Vol. 12. Date of Electronic Publication: 2023 Apr 18. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012- |
مواضيع طبية MeSH: | Memory, Short-Term* , Glutamic Acid*, Humans ; Aged ; Learning ; Reinforcement, Psychology ; Task Performance and Analysis ; Prefrontal Cortex/diagnostic imaging |
مستخلص: | The ability to use past experience to effectively guide decision-making declines in older adulthood. Such declines have been theorized to emerge from either impairments of striatal reinforcement learning systems (RL) or impairments of recurrent networks in prefrontal and parietal cortex that support working memory (WM). Distinguishing between these hypotheses has been challenging because either RL or WM could be used to facilitate successful decision-making in typical laboratory tasks. Here we investigated the neurocomputational correlates of age-related decision-making deficits using an RL-WM task to disentangle these mechanisms, a computational model to quantify them, and magnetic resonance spectroscopy to link them to their molecular bases. Our results reveal that task performance is worse in older age, in a manner best explained by working memory deficits, as might be expected if cortical recurrent networks were unable to sustain persistent activity across multiple trials. Consistent with this, we show that older adults had lower levels of prefrontal glutamate, the excitatory neurotransmitter thought to support persistent activity, compared to younger adults. Individuals with the lowest prefrontal glutamate levels displayed the greatest impairments in working memory after controlling for other anatomical and metabolic factors. Together, our results suggest that lower levels of prefrontal glutamate may contribute to failures of working memory systems and impaired decision-making in older adulthood. Competing Interests: MR, MH, BB, EW, EF, AC, MN No competing interests declared (© 2023, Rmus et al.) |
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معلومات مُعتمدة: | K99 AG054732 United States AG NIA NIH HHS; R00 AG054732 United States AG NIA NIH HHS |
فهرسة مساهمة: | Keywords: PFC; aging; computational modeling; glutamate; human; neuroscience; reinforcement learning; working memory |
المشرفين على المادة: | 3KX376GY7L (Glutamic Acid) |
تواريخ الأحداث: | Date Created: 20230418 Date Completed: 20230515 Latest Revision: 20230524 |
رمز التحديث: | 20230524 |
مُعرف محوري في PubMed: | PMC10174689 |
DOI: | 10.7554/eLife.85243 |
PMID: | 37070807 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2050-084X |
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DOI: | 10.7554/eLife.85243 |